ID   RGF1A_XENTR             Reviewed;         475 AA.
AC   A0JM95;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Ras-GEF domain-containing family member 1A;
GN   Name=rasgef1a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF) with specificity for
CC       rap2a and other Ras family proteins (in vitro). Plays a role in cell
CC       migration (By similarity). {ECO:0000250}.
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DR   EMBL; BC125791; AAI25792.1; -; mRNA.
DR   RefSeq; NP_001039175.2; NM_001045710.2.
DR   RefSeq; XP_012822159.1; XM_012966705.2.
DR   AlphaFoldDB; A0JM95; -.
DR   SMR; A0JM95; -.
DR   STRING; 8364.ENSXETP00000001335; -.
DR   PaxDb; A0JM95; -.
DR   DNASU; 734010; -.
DR   Ensembl; ENSXETT00000001335; ENSXETP00000001335; ENSXETG00000000607.
DR   GeneID; 734010; -.
DR   KEGG; xtr:734010; -.
DR   CTD; 221002; -.
DR   Xenbase; XB-GENE-5739365; rasgef1a.
DR   eggNOG; KOG3541; Eukaryota.
DR   HOGENOM; CLU_022907_2_0_1; -.
DR   InParanoid; A0JM95; -.
DR   OMA; KKAITQM; -.
DR   OrthoDB; 533115at2759; -.
DR   TreeFam; TF313379; -.
DR   Reactome; R-XTR-5673001; RAF/MAP kinase cascade.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000607; Expressed in brain and 9 other tissues.
DR   ExpressionAtlas; A0JM95; baseline.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..475
FT                   /note="Ras-GEF domain-containing family member 1A"
FT                   /id="PRO_0000297636"
FT   DOMAIN          33..164
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT   DOMAIN          208..455
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
SQ   SEQUENCE   475 AA;  54787 MW;  4F6660CA819E02C6 CRC64;
     MPQTPIFPSM LGSTCSGQVQ PEMGEHCGDP VYQDGSLVSG SLEVLIERLV PTLDYYPDKT
     YIFTFLLSAR IFIHPYEILA KVGQMCIKQK QQLESGSEAD KAKLKSFAAK IIQLLREWTE
     TFPFDFQDER ARKEMKEIAQ RITQCDEENG TIKKSISQMT QNVLVVLSTR GQFQEVREKI
     RQPVSDKGTI LKTKPQSAQK DILSVCSDPL ILAQQLTTIE LERLGNIFPE DLMQIISHMD
     SLDNHKCRSD VTKTYNLEAY DNWFNCLSML VATEICKVVK KKQRTRVMEF FIDVARECFN
     IGNFNSMMAI ISGMNLSPVA RLKKTWSKVK TAKFDVLEHH MDPSSNFCNY RTALQGATQR
     SQSANSSREK IVIPVFNLFI KDIFFLHKIH SNRLPNGHIN FKKFWEISRQ IHDFLTWKQV
     ECPYEKDKKI QTYLLTTPIY TEEALFLASF ENEGPDNHME KDSWKTLRST LLNRA