ID   RGF1B_XENTR             Reviewed;         472 AA.
AC   Q28EC1;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Ras-GEF domain-containing family member 1B;
GN   Name=rasgef1b; ORFNames=TNeu048b05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF) with specificity for
CC       rap2a and other Ras family proteins (in vitro). {ECO:0000250}.
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DR   EMBL; CR848333; CAJ83352.1; -; mRNA.
DR   RefSeq; NP_001016913.1; NM_001016913.2.
DR   AlphaFoldDB; Q28EC1; -.
DR   SMR; Q28EC1; -.
DR   STRING; 8364.ENSXETP00000027482; -.
DR   PaxDb; Q28EC1; -.
DR   GeneID; 549667; -.
DR   KEGG; xtr:549667; -.
DR   CTD; 153020; -.
DR   Xenbase; XB-GENE-1015760; rasgef1b.
DR   eggNOG; KOG3541; Eukaryota.
DR   HOGENOM; CLU_022907_2_0_1; -.
DR   InParanoid; Q28EC1; -.
DR   OrthoDB; 533115at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Ras-GEF domain-containing family member 1B"
FT                   /id="PRO_0000297642"
FT   DOMAIN          34..164
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT   DOMAIN          204..452
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
SQ   SEQUENCE   472 AA;  55307 MW;  3EA950E2E57EC9F7 CRC64;
     MPQTPTLVAM FDSSSFHRNL YQSKEESCSE LYYQDNNLLS GSLEALIQHL VPNVDYYPDR
     TYIFTFLLSS RLFIHPSELM ARVCHVCMEQ QRLNEPGLDK SQVRKIAPKI LQLLTEWTET
     FPYDFRDERM MRNLKDTAHR ITNGDEMYRK NVQQIIQNLI RKLASLTQYE ELITKINAQS
     TDRMTVLKTK PQSIQRDIIT VCSDPYTVAQ QLTHIELERL SYIGPEEFVQ AFVQKDPLDN
     NENCYSDRKK PRNLEAYVEW FNRLSYLVAT EICMPVKKKH RARMIEFFID VARECFNIGN
     FNSLMAIISG MNMSPVSRLK KTWAKVKTAK FDILEHQMDP SSNFYNYRTA LRGAAQRSLT
     AHSNREKIVI PFCSLLIKDI YFLNEGCTSR LPNGHVNFEK FWELAKQVSE FMTWKQVECP
     FEKDRKILHY VLTAPIFSED ALYLASYESE GPENHIEKDR WKTLRSALLG RA