ID   RGF1C_MACFA             Reviewed;         466 AA.
AC   Q95KH6;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Ras-GEF domain-containing family member 1C;
GN   Name=RASGEF1C; ORFNames=QtrA-12086;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF). {ECO:0000250}.
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DR   EMBL; AB060868; BAB46881.1; -; mRNA.
DR   AlphaFoldDB; Q95KH6; -.
DR   SMR; Q95KH6; -.
DR   STRING; 9541.XP_005558854.1; -.
DR   eggNOG; KOG3541; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..466
FT                   /note="Ras-GEF domain-containing family member 1C"
FT                   /id="PRO_0000297644"
FT   DOMAIN          34..164
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT   DOMAIN          200..446
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          443..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..460
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   466 AA;  52886 MW;  52A498542F92108F CRC64;
     MPQTLSASDM VTPGSLSPPT TEPTDGEQAG QPLLDGAPSS ASLETLIQHL VPTADYYPEK
     AYIFTFLLSS RLFIEPRELL ARVCHLCIEQ QQLDKPVLDK ARVRKFGPKL LQLLAEWTET
     FPRDFQEEST IGQLKDVVGR IAPCDETYRK RMHQLLQALH QKLAALRQGP EGLVSADKPI
     SYRTKPPASI HRELLGVCSD PYTLAQQLTH VELERLRHIG PEEFVQAFVN KDPLASTKPC
     FSDKTSHLEA YVKWFNRLCY LVATEICMPA KKKQRAQVIE FFIDVARECF NIGNFNSLMA
     IISGMNMSPV SRLKKTWAKV KTAKFFILEH QMDPTGNFCN YRTALRGAAH RSLTAHSSRE
     KIVIPFFSLL IKDIYFLNEG CANRLPNGHV NFEKFLELAK QVGEFITWKQ VECPFEQDPS
     ITHYLSTAPI FSEDGLYLAS YESESPENQT EKERWKSLRS SILGKT