RGF1C_MOUSE
ID RGF1C_MOUSE Reviewed; 466 AA.
AC Q9D300; Q8BYJ7;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ras-GEF domain-containing family member 1C;
GN Name=Rasgef1c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cecum, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Guanine nucleotide exchange factor (GEF). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D300-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D300-2; Sequence=VSP_027317;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI23944.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI24373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK018593; BAB31297.1; -; mRNA.
DR EMBL; AK039330; BAC30320.1; -; mRNA.
DR EMBL; AL606479; CAI23944.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL645913; CAI23944.1; JOINED; Genomic_DNA.
DR EMBL; AL645913; CAI24373.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL606479; CAI24373.1; JOINED; Genomic_DNA.
DR CCDS; CCDS24625.1; -. [Q9D300-1]
DR CCDS; CCDS83798.1; -. [Q9D300-2]
DR RefSeq; NP_001334391.1; NM_001347462.1. [Q9D300-2]
DR RefSeq; NP_083280.1; NM_029004.1. [Q9D300-1]
DR RefSeq; XP_011247592.1; XM_011249290.2.
DR AlphaFoldDB; Q9D300; -.
DR SMR; Q9D300; -.
DR STRING; 10090.ENSMUSP00000090829; -.
DR iPTMnet; Q9D300; -.
DR PhosphoSitePlus; Q9D300; -.
DR PaxDb; Q9D300; -.
DR PRIDE; Q9D300; -.
DR ProteomicsDB; 255246; -. [Q9D300-1]
DR ProteomicsDB; 255247; -. [Q9D300-2]
DR Antibodypedia; 29571; 143 antibodies from 25 providers.
DR DNASU; 74563; -.
DR Ensembl; ENSMUST00000063444; ENSMUSP00000065619; ENSMUSG00000020374. [Q9D300-2]
DR Ensembl; ENSMUST00000093142; ENSMUSP00000090829; ENSMUSG00000020374. [Q9D300-1]
DR GeneID; 74563; -.
DR KEGG; mmu:74563; -.
DR UCSC; uc007irj.1; mouse. [Q9D300-1]
DR CTD; 255426; -.
DR MGI; MGI:1921813; Rasgef1c.
DR VEuPathDB; HostDB:ENSMUSG00000020374; -.
DR eggNOG; KOG3541; Eukaryota.
DR GeneTree; ENSGT00940000161005; -.
DR HOGENOM; CLU_022907_2_0_1; -.
DR InParanoid; Q9D300; -.
DR OMA; LDGTKPC; -.
DR OrthoDB; 533115at2759; -.
DR PhylomeDB; Q9D300; -.
DR TreeFam; TF313379; -.
DR BioGRID-ORCS; 74563; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9D300; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D300; protein.
DR Bgee; ENSMUSG00000020374; Expressed in superior frontal gyrus and 56 other tissues.
DR ExpressionAtlas; Q9D300; baseline and differential.
DR Genevisible; Q9D300; MM.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; PTHR23113; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; SSF48366; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Guanine-nucleotide releasing factor;
KW Reference proteome.
FT CHAIN 1..466
FT /note="Ras-GEF domain-containing family member 1C"
FT /id="PRO_0000297645"
FT DOMAIN 34..164
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT DOMAIN 200..446
FT /note="Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MAGM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027317"
SQ SEQUENCE 466 AA; 52723 MW; 4B08740856D20A15 CRC64;
MPRTLTASDM VTPGSLSPPP TESTEGEQAG QPLLDGAPSS ASLDTLIQHL VPTADYYPEK
AYIFTFLLSS RLFIEPRELL ARVCHLCIEQ QQLDKPVLDK ARVRKFGAKL LQLLAEWTET
FPRDFEEEST IGHLTDVVGR ISPCDETYGS RVHQLLQTLH QKLASLGQGP ESLVGADKPI
SYRTKPPASI HRELLGVCSD PYTLAQQLTH VELERLRHIG PEEFVQAFVN KDPLAGTKPR
FSDKTNNVEA YVKWFNRLCY LVATEICMPA KKKQRAQVIE FFIDVARECF NIGNFNSLMA
IISGMNMSPV SRLKKTWAKV KTAKFFILEH QMDPTGNFCN YRTALRGAAH RSLTAHSSRE
KIVIPFFSLL IKDIYFLNEG CANRLPNGHV NFEKFLELAK QVGEFITWKQ VECPFEQDPS
ITHYLYTAPI FSEDGLYLAS YESESPESQT EKERWKSLRS SILGKT
