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RGHR_BACSU
ID   RGHR_BACSU              Reviewed;         135 AA.
AC   O32236; Q79D98;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=HTH-type transcriptional repressor RghR;
DE   AltName: Full=RapGH repressor;
GN   Name=rghR; Synonyms=rghRA, yvaN; OrderedLocusNames=BSU33660;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 6633 / PCI 219 / NRS 231;
RA   Klein C.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION AS A REPRESSOR, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168;
RX   PubMed=16553878; DOI=10.1111/j.1365-2958.2006.05059.x;
RA   Hayashi K., Kensuke T., Kobayashi K., Ogasawara N., Ogura M.;
RT   "Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode
RT   inhibitors of expression of the srfA operon.";
RL   Mol. Microbiol. 59:1714-1729(2006).
CC   -!- FUNCTION: Represses the expression of yvaM and both rapG and rapH.
CC       Binds directly to the promoter regions of yvaM, rapG and rapH.
CC       {ECO:0000269|PubMed:16553878}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene display a derepression of
CC       rapG and rapH expression, which leads to a down-regulation of sfrA that
CC       in turn leads to the expression abolition of both comK and the late com
CC       operon comG. {ECO:0000269|PubMed:16553878}.
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DR   EMBL; U09819; AAB91590.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15371.1; -; Genomic_DNA.
DR   PIR; C70028; C70028.
DR   RefSeq; NP_391246.1; NC_000964.3.
DR   RefSeq; WP_003220034.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; O32236; -.
DR   SMR; O32236; -.
DR   IntAct; O32236; 1.
DR   STRING; 224308.BSU33660; -.
DR   PaxDb; O32236; -.
DR   PRIDE; O32236; -.
DR   EnsemblBacteria; CAB15371; CAB15371; BSU_33660.
DR   GeneID; 64305127; -.
DR   GeneID; 936180; -.
DR   KEGG; bsu:BSU33660; -.
DR   PATRIC; fig|224308.179.peg.3651; -.
DR   eggNOG; COG1396; Bacteria.
DR   InParanoid; O32236; -.
DR   OMA; ERENWRH; -.
DR   PhylomeDB; O32236; -.
DR   BioCyc; BSUB:BSU33660-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR016759; RghR.
DR   PIRSF; PIRSF019364; RapGH_repressor; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..135
FT                   /note="HTH-type transcriptional repressor RghR"
FT                   /id="PRO_0000232704"
FT   DOMAIN          8..63
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   135 AA;  15446 MW;  779152435C6FB05A CRC64;
     MESFGEQLRA LREERKLTVN QLATYSGVSA AGISRIENGK RGVPKPATIK KLAEALKIPY
     EGLMYKAGYI EEVHEARAPY ETKCKLLEKA EAYDLKNLAL LENEKWQYLN KEDLLMLDHY
     FSFISDEAKK RSADD
 
 
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