ID   RGI1_CANAL              Reviewed;         201 AA.
AC   Q59KG2; A0A1D8PI91;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Respiratory growth induced protein 1;
GN   Name=RGI1; OrderedLocusNames=CAALFM_C208290CA;
GN   ORFNames=CaO19.1354, CaO19.2659, CaO19.8934;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   INDUCTION.
RX   PubMed=12654650; DOI=10.1128/aac.47.4.1220-1227.2003;
RA   Rogers P.D., Barker K.S.;
RT   "Genome-wide expression profile analysis reveals coordinately regulated
RT   genes associated with stepwise acquisition of azole resistance in Candida
RT   albicans clinical isolates.";
RL   Antimicrob. Agents Chemother. 47:1220-1227(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=15269278; DOI=10.1091/mbc.e04-02-0144;
RA   Harcus D., Nantel A., Marcil A., Rigby T., Whiteway M.;
RT   "Transcription profiling of cyclic AMP signaling in Candida albicans.";
RL   Mol. Biol. Cell 15:4490-4499(2004).
RN   [6]
RP   INDUCTION.
RX   PubMed=20435697; DOI=10.1128/ec.00034-10;
RA   Rosenbach A., Dignard D., Pierce J.V., Whiteway M., Kumamoto C.A.;
RT   "Adaptations of Candida albicans for growth in the mammalian intestinal
RT   tract.";
RL   Eukaryot. Cell 9:1075-1086(2010).
CC   -!- FUNCTION: Involved in the control of energetic metabolism and
CC       significantly contribute to cell fitness, especially under respiratory
CC       growth conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- INDUCTION: Expression is under the control of RAS1. Up-regulated during
CC       colonization of the cecum and invasion of host tissue. Down-regulation
CC       correlates with clinical development of fluconazole resistance.
CC       {ECO:0000269|PubMed:12654650, ECO:0000269|PubMed:15269278,
CC       ECO:0000269|PubMed:20435697}.
CC   -!- SIMILARITY: Belongs to the RGI1 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27820.1; -; Genomic_DNA.
DR   RefSeq; XP_710084.1; XM_704992.2.
DR   AlphaFoldDB; Q59KG2; -.
DR   SMR; Q59KG2; -.
DR   BioGRID; 1231250; 2.
DR   STRING; 237561.Q59KG2; -.
DR   PRIDE; Q59KG2; -.
DR   GeneID; 3648170; -.
DR   KEGG; cal:CAALFM_C208290CA; -.
DR   CGD; CAL0000189412; UCF1.
DR   VEuPathDB; FungiDB:C2_08290C_A; -.
DR   eggNOG; ENOG502S6JA; Eukaryota.
DR   HOGENOM; CLU_118207_0_0_1; -.
DR   InParanoid; Q59KG2; -.
DR   OMA; FKRNLQH; -.
DR   OrthoDB; 1417399at2759; -.
DR   PRO; PR:Q59KG2; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006112; P:energy reserve metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1000.40; -; 1.
DR   InterPro; IPR022554; RGI1.
DR   InterPro; IPR038235; RGI1_sf.
DR   Pfam; PF10843; RGI1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..201
FT                   /note="Respiratory growth induced protein 1"
FT                   /id="PRO_0000402279"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   201 AA;  23654 MW;  759CD16DEC7A47A9 CRC64;
     MAGKKKSKSE ALPLDLDNIK PMDHLQPVPK TRSSSITSIE SADEPGTMKQ VLLPPTIKEF
     DELEQFESFV RDETWDNDFD YFHGRLHYYP PFVMKSCQNN LEKIKPTMNK NSKKFRRDLQ
     HHIQKHLIKD LEKCCGYELN FGKGEVVETD NKVTWKFKDE TDHGFSKEEE DMYDRHWRLE
     LDVSCTNESA MVDVEYKSIP M