RGI2_YEAST
ID RGI2_YEAST Reviewed; 164 AA.
AC P40188; D6VVM5;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Respiratory growth induced protein 2;
GN Name=RGI2; OrderedLocusNames=YIL057C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP INDUCTION.
RX PubMed=12414795; DOI=10.1074/jbc.m209759200;
RA Boer V.M., de Winde J.H., Pronk J.T., Piper M.D.W.;
RT "The genome-wide transcriptional responses of Saccharomyces cerevisiae
RT grown on glucose in aerobic chemostat cultures limited for carbon,
RT nitrogen, phosphorus, or sulfur.";
RL J. Biol. Chem. 278:3265-3274(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP INDUCTION.
RX PubMed=16969341; DOI=10.1038/msb4100083;
RA Kresnowati M.T., van Winden W.A., Almering M.J., ten Pierick A., Ras C.,
RA Knijnenburg T.A., Daran-Lapujade P., Pronk J.T., Heijnen J.J., Daran J.M.;
RT "When transcriptome meets metabolome: fast cellular responses of yeast to
RT sudden relief of glucose limitation.";
RL Mol. Syst. Biol. 2:49-49(2006).
RN [8]
RP FUNCTION.
RX PubMed=20567505; DOI=10.1371/journal.pone.0011163;
RA Domitrovic T., Kozlov G., Freire J.C., Masuda C.A., da Silva Almeida M.,
RA Montero-Lomeli M., Atella G.C., Matta-Camacho E., Gehring K.,
RA Kurtenbach E.;
RT "Structural and functional study of YER067W, a new protein involved in
RT yeast metabolism control and drug resistance.";
RL PLoS ONE 5:E11163-E11163(2010).
CC -!- FUNCTION: Involved in the control of energetic metabolism and
CC significantly contribute to cell fitness, especially under respiratory
CC growth conditions. {ECO:0000269|PubMed:20567505}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC -!- INDUCTION: Up-regulated under carbon limitation and repressed under
CC high glucose. {ECO:0000269|PubMed:12414795,
CC ECO:0000269|PubMed:16969341}.
CC -!- MISCELLANEOUS: Present with 5530 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RGI1 family. {ECO:0000305}.
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DR EMBL; Z38060; CAA86166.1; -; Genomic_DNA.
DR EMBL; AY558086; AAS56412.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08491.1; -; Genomic_DNA.
DR PIR; S48422; S48422.
DR RefSeq; NP_012207.3; NM_001179407.3.
DR AlphaFoldDB; P40188; -.
DR SMR; P40188; -.
DR BioGRID; 34933; 75.
DR DIP; DIP-5500N; -.
DR STRING; 4932.YIL057C; -.
DR CarbonylDB; P40188; -.
DR iPTMnet; P40188; -.
DR PaxDb; P40188; -.
DR PRIDE; P40188; -.
DR EnsemblFungi; YIL057C_mRNA; YIL057C; YIL057C.
DR GeneID; 854753; -.
DR KEGG; sce:YIL057C; -.
DR SGD; S000001319; RGI2.
DR VEuPathDB; FungiDB:YIL057C; -.
DR eggNOG; ENOG502RZ9F; Eukaryota.
DR GeneTree; ENSGT00940000176408; -.
DR HOGENOM; CLU_118207_0_0_1; -.
DR InParanoid; P40188; -.
DR OMA; FKRNLQH; -.
DR BioCyc; YEAST:G3O-31327-MON; -.
DR PRO; PR:P40188; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40188; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0006112; P:energy reserve metabolic process; IMP:SGD.
DR Gene3D; 3.40.1000.40; -; 1.
DR InterPro; IPR022554; RGI1.
DR InterPro; IPR038235; RGI1_sf.
DR Pfam; PF10843; RGI1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..164
FT /note="Respiratory growth induced protein 2"
FT /id="PRO_0000202987"
SQ SEQUENCE 164 AA; 19229 MW; FE106D9EE90D28EA CRC64;
MTKKDKKAKG PKMSTITTKS GESLKVFEDL HDFETYLKGE TEDQEFDHVH CQLKYYPPFV
LHDAHDDPEK IKETANSHSK KFVRHLHQHV EKHLLKDIKT AINKPELKFH DKKKQESFDR
IVWNYGEETE LNAKKFKVSV EVVCKHDGAM VDVDYKTEPL QPLI
