ID   RGL1_DANRE              Reviewed;         804 AA.
AC   Q6P112;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Ral guanine nucleotide dissociation stimulator-like 1;
DE            Short=RalGDS-like 1;
GN   Name=rgl1; ORFNames=zgc:77299;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable guanine nucleotide exchange factor.
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DR   EMBL; BC065335; AAH65335.1; -; mRNA.
DR   AlphaFoldDB; Q6P112; -.
DR   SMR; Q6P112; -.
DR   STRING; 7955.ENSDARP00000120417; -.
DR   PaxDb; Q6P112; -.
DR   PRIDE; Q6P112; -.
DR   ZFIN; ZDB-GENE-040426-1816; rgl1.
DR   eggNOG; KOG3629; Eukaryota.
DR   InParanoid; Q6P112; -.
DR   PhylomeDB; Q6P112; -.
DR   Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
DR   PRO; PR:Q6P112; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR030748; RGL1.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF199; PTHR23113:SF199; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..804
FT                   /note="Ral guanine nucleotide dissociation stimulator-like
FT                   1"
FT                   /id="PRO_0000306798"
FT   DOMAIN          101..231
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT   DOMAIN          270..539
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT   DOMAIN          684..771
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   REGION          564..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          640..676
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        564..609
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        661..676
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  89690 MW;  623607589ED40182 CRC64;
     MISHYPLASL LPWPPVPQLL DIDGDGGVAL QRYQPRSPET GPRYWSSVQD WGEEVEEGAI
     YNVTLKRVQI QQAANKGARW LGAEGDRLPP GHTVSQLETC KIRSIRAGTL ERLVETLLTA
     FGDNDLTYTS IFLSTYRAFA STQSVLELLL DRYGSFEDCE GERSQCQTGE SRKAVRKALA
     SILRAWLDQC PEDFQEPPSY PSLHRVLGFL QKAMPGSEPM RRAQSLLEQL RVQASLENET
     EGGFQCINPF CLGEDEEVEI DLQEDFFSFE VDLVAEQLTY MDALLFKKVV PHHCLGSIWS
     QRDKKDGKQS APTIRATITQ FNAVTACVVS TILRQRQIRP HLCARIIQRW IDIAQECRIR
     KNFSSLRAIV SALQSNPLYR LKRTWASVAK DSMQMFEELS DIFSDQNNYL TSRELLMREG
     TSKFASLDSC AKDHQKRSQK RLQLQKDMGA MQGTIPYLGT FLTDLTMLDT ALPDQVEGGL
     INFEKRRREF EVIAQIKLLQ SACNSYCLTP DPAFFRWFKS QPQYSEEESY VLSCEVEGLG
     DNSPTSPKPR KSMVKRLSLL FLGNDSTNTS SPVRESPRSP PTGSSGESMD SVSVSSSDSS
     PSESDGMTPT HSIDAHLKKL SESSSCNSLH SMDTSSSTAS ASISLASPTL PGPPCNHRRS
     ISLTPLMSPT SPGFPPAYNT QAQDACIIRV SLEQGNGNLY KSIMLTSQDK TPAVISRAMT
     KHNLEGEQAA DYELVQVISE ERELVIPDNA NVFYAMSTSA NFDFLLRLRG SEGRPVQLRS
     RCSSTLPRTQ QRSSLSLRLS KVTL