ID   RGL2_CANLF              Reviewed;         780 AA.
AC   Q5TJE5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Ral guanine nucleotide dissociation stimulator-like 2;
DE            Short=RalGDS-like 2;
DE   AltName: Full=Ras-associated protein RAB2L;
GN   Name=RGL2; Synonyms=RAB2L;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Doberman pinscher;
RX   PubMed=15607421; DOI=10.1016/j.ygeno.2004.09.009;
RA   Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A.,
RA   Ollier W.E.R., Binns M.M.;
RT   "Genomic sequence of the class II region of the canine MHC: comparison with
RT   the MHC of other mammalian species.";
RL   Genomics 85:48-59(2005).
CC   -!- FUNCTION: Probable guanine nucleotide exchange factor. Putative
CC       effector of Ras and/or Rap. Associates with the GTP-bound form of Rap
CC       1A and H-Ras in vitro (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SAMD9. {ECO:0000250}.
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DR   EMBL; AJ630366; CAI11443.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5TJE5; -.
DR   SMR; Q5TJE5; -.
DR   STRING; 9612.ENSCAFP00000001375; -.
DR   PaxDb; Q5TJE5; -.
DR   PRIDE; Q5TJE5; -.
DR   eggNOG; KOG3629; Eukaryota.
DR   InParanoid; Q5TJE5; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR030749; RGL2.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF213; PTHR23113:SF213; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome.
FT   CHAIN           1..780
FT                   /note="Ral guanine nucleotide dissociation stimulator-like
FT                   2"
FT                   /id="PRO_0000068887"
FT   DOMAIN          89..213
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT   DOMAIN          244..516
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT   DOMAIN          651..738
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          596..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..60
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        741..758
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         13
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O15211"
SQ   SEQUENCE   780 AA;  84060 MW;  241F0F86A986CABA CRC64;
     MLPRPLRLLW DASPPGGVVL SSFRSRDPEE GGGPGGRGVG GGQEEEEEEE EDEAPVSVWD
     EEEDGATFTV TSRQYRPLDP LAPTPPPRSS RRLRAGTLEA LVRHLLDART SGADVTFTPA
     FLATHRAFTS TPALLGLVAD RLEALESHPT DELERTIGVA TSVLSTWLAS HPEDFGSEVK
     GQLDRLESFL LRTGYAAGEG VGGGSADLIR NLRFRVDPQA PDLPKPLALP GDPPADPTDV
     LVFLADHLAE QLTLLDAELF LHLVPSQCLG SLWGHRDRPG HSHLCPSVRA TVTQFNKVAG
     AVVSSVLGAT SAGEGPGEVT IRPLRPPQRA RLLEKWIRVA EECRLLRNFS SVYAVVSALQ
     SSPIHRLRAA WGEATRDSLR VFSSLCQIFS EEDNYSQSRE LLLQEVKLQP SLESNSKKAP
     RSGSGSRGGG VVPYLGTFLK DLVMLDAASK DELENGYINF DKRRKEFAVL SELRRLQNEC
     RGYDLRPDPD IQQWLRGLRP LTEAQSHRVS CEVEPPGTSD PPAPRVLRPT LVVSQWTEVL
     GSVGGPTPLV SWDRPSVGGE EVPGTPAPLL TRLAQHMKWP SVSSLDSALE STPYLHSLAD
     PSHLSPPASS PRPSRGHRRS ASCGSPLSGG AEGASKGTEY RGGGSGPGAS DCRIIRVQME
     LGEDGSVYKS ILVTSQDKAP SVISRVLKKN NRDSAVASEY ELVQLLPGER ELTIPPSANV
     FYAMDGASHD FLLRQRRRPS TATLGLTSSP SASGTPPSEG GGGSFPRIKA TGRKIARALF