ID   RGP1_BOVIN              Reviewed;         394 AA.
AC   Q2T9P3;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=RAB6A-GEF complex partner protein 2 {ECO:0000305};
DE   AltName: Full=Retrograde Golgi transport protein RGP1 homolog {ECO:0000250|UniProtKB:P16664};
GN   Name=RGP1 {ECO:0000250|UniProtKB:P16664};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange
CC       factor (GEF), which activates RAB6A by exchanging bound GDP for free
CC       GTP and may thereby required for efficient fusion of endosome-derived
CC       vesicles with the Golgi compartment. The RIC1-RGP1 complex participates
CC       in the recycling of mannose-6-phosphate receptors.
CC       {ECO:0000250|UniProtKB:Q92546}.
CC   -!- SUBUNIT: Forms a complex with RIC1; the interaction enhances RAB6A
CC       GTPase activity. Interacts with RIC1. Interacts with RAB6A; the
CC       interaction is direct with a preference for RAB6A-GDP. Interacts with
CC       RAB33B. {ECO:0000250|UniProtKB:Q92546}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q92546}. Membrane
CC       {ECO:0000250|UniProtKB:Q92546}.
CC   -!- SIMILARITY: Belongs to the RGP1 family. {ECO:0000305}.
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DR   EMBL; BC111331; AAI11332.1; -; mRNA.
DR   RefSeq; NP_001033273.1; NM_001038184.1.
DR   AlphaFoldDB; Q2T9P3; -.
DR   STRING; 9913.ENSBTAP00000015196; -.
DR   PaxDb; Q2T9P3; -.
DR   PRIDE; Q2T9P3; -.
DR   GeneID; 539393; -.
DR   KEGG; bta:539393; -.
DR   CTD; 9827; -.
DR   eggNOG; KOG4469; Eukaryota.
DR   InParanoid; Q2T9P3; -.
DR   OrthoDB; 450058at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR   GO; GO:0034066; C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR   GO; GO:0042177; P:negative regulation of protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB.
DR   InterPro; IPR014848; Rgp1.
DR   PANTHER; PTHR12507; PTHR12507; 2.
DR   Pfam; PF08737; Rgp1; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..394
FT                   /note="RAB6A-GEF complex partner protein 2"
FT                   /id="PRO_0000274474"
SQ   SEQUENCE   394 AA;  43098 MW;  41476EE00D333F43 CRC64;
     MIEVVAELSR GPVFLAGEAL ECVVTVTNPL PPTATSASSE ALAWASAQIH CQFHASESRV
     ALPPPDSSQP DVQPESQTVL LPHRGERGQC ILSTPPKILF CDLRLDPGES KSYSYSEVLP
     VEGPPSFRGQ SVKYVYKLTI GCQRVNSPIT LLRVPLRVLV LTGLQDVRFP QDEAVAPSSP
     FLEEDEGGKK DSWLTELAGE RLMAATSCRS LHLYNISDGR GKVGTFGIFK SVYRLGEDVV
     GTLNLGEGTV ACLQYSVSLQ TEERVQPEYQ RRRGAGGAPS VSHITHARHQ ESCLHTTRTS
     FSLPIPLSST PGFCTAIVSL KWRLHFEFVT SREPGLVLLP PVEQPEPATW TGPEQVPVDT
     FSWDLPIKPE ASHTFLSVQP ASYCYSVRSH IRAI