RGP2_CAEEL
ID RGP2_CAEEL Reviewed; 960 AA.
AC P34342; Q8MYR0; Q8TA79;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Ran GTPase-activating protein 2;
DE AltName: Full=Ran nuclear import/export-related protein 2;
DE AltName: Full=RanGAP;
GN Name=ran-2; ORFNames=C29E4.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11909538; DOI=10.1016/s0960-9822(02)00741-8;
RA Bamba C., Bobinnec Y., Fukuda M., Nishida E.;
RT "The GTPase Ran regulates chromosome positioning and nuclear envelope
RT assembly in vivo.";
RL Curr. Biol. 12:503-507(2002).
CC -!- FUNCTION: GTPase system comprising ran-1, ran-2 and ran-3 is essential
CC in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the
CC nuclear RAS-related regulatory protein Ran, converting it to the
CC putatively inactive GDP-bound state. Required for correct chromosome
CC alignment and segregation on the metaphase plate.
CC {ECO:0000269|PubMed:11909538}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11909538}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34342-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34342-2; Sequence=VSP_014340, VSP_008709;
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DR EMBL; FO080706; CCD66004.1; -; Genomic_DNA.
DR EMBL; FO080706; CCD66005.1; -; Genomic_DNA.
DR PIR; S44770; S44770.
DR RefSeq; NP_741232.1; NM_171198.4. [P34342-2]
DR RefSeq; NP_741233.2; NM_171884.4. [P34342-1]
DR AlphaFoldDB; P34342; -.
DR BioGRID; 41322; 7.
DR IntAct; P34342; 3.
DR STRING; 6239.C29E4.3a; -.
DR iPTMnet; P34342; -.
DR EPD; P34342; -.
DR PaxDb; P34342; -.
DR PeptideAtlas; P34342; -.
DR EnsemblMetazoa; C29E4.3a.1; C29E4.3a.1; WBGene00004303. [P34342-1]
DR EnsemblMetazoa; C29E4.3b.1; C29E4.3b.1; WBGene00004303. [P34342-2]
DR EnsemblMetazoa; C29E4.3b.2; C29E4.3b.2; WBGene00004303. [P34342-2]
DR GeneID; 176115; -.
DR KEGG; cel:CELE_C29E4.3; -.
DR UCSC; C29E4.3a; c. elegans. [P34342-1]
DR CTD; 176115; -.
DR WormBase; C29E4.3a; CE37483; WBGene00004303; ran-2. [P34342-1]
DR WormBase; C29E4.3b; CE30621; WBGene00004303; ran-2. [P34342-2]
DR eggNOG; KOG1909; Eukaryota.
DR GeneTree; ENSGT00440000039203; -.
DR InParanoid; P34342; -.
DR OMA; CRDKGAL; -.
DR OrthoDB; 283061at2759; -.
DR PhylomeDB; P34342; -.
DR Reactome; R-CEL-3108232; SUMO E3 ligases SUMOylate target proteins.
DR Reactome; R-CEL-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR PRO; PR:P34342; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00004303; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 3.
PE 4: Predicted;
KW Alternative splicing; Cell cycle; Cell division; GTPase activation;
KW Leucine-rich repeat; Mitosis; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..960
FT /note="Ran GTPase-activating protein 2"
FT /id="PRO_0000097320"
FT REPEAT 69..92
FT /note="LRR 1"
FT REPEAT 132..156
FT /note="LRR 2"
FT REPEAT 162..185
FT /note="LRR 3"
FT REPEAT 227..254
FT /note="LRR 4"
FT REPEAT 313..340
FT /note="LRR 5"
FT REPEAT 475..498
FT /note="LRR 6"
FT REPEAT 538..561
FT /note="LRR 7"
FT REPEAT 568..595
FT /note="LRR 8"
FT REPEAT 663..685
FT /note="LRR 9"
FT REGION 370..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..396
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..37
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_014340"
FT VAR_SEQ 919
FT /note="K -> KTLQ (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_008709"
SQ SEQUENCE 960 AA; 105653 MW; 06F6C6346E4C72A4 CRC64;
MLPRLFLTIL PVCSPSISNK TSKKFRDAHA NHVFLFEMDL NNTLSFFGKQ LKLDTEEEIS
KVIDQIRKHL NLEVLDFRGN TLSVLAGKLI AESLKTRREL KECIWSDMFT GRLKDEIPLV
LDALGEALTA SGCRLTTLDL SDNAFGAGLS TSLYNFLQSP ALYSLENLIL NNNGLGLAGK
TVGKALCSLI DASKKAGTPL KLKKFVCGRN RLEVESTIAL SDAFIKLGTL EEIRLPQNGI
RDDGIIALAE AFRMNKKLRI IDINDNFCCP EGAIQISEVL SDLQFIEVLD LGDCVCDDPG
VLAIIAELDK INRDCLKKVV LSGNNITSDV IDEIGACFNS PKMCHVKVDI SVNMFGKDFD
SAKARHGKGN IDFGRRGDDE LLSSDEEEEQ GAEDASMEED AFNTSRETVI DRSNLHEASA
DEMMNDLMNK GFGCMKIEDN QQNSNGNGMV SFLDKSLKLD TAESAEPVVK VIAAASSMKA
LELRGNTLGI AAGNVIAKAL ESHPELERCL WSDLFTGRLK NEIPPILEAL GKAMMTAGCK
IKELDLSDNA FGPIGADALK DLLESPSSFS LEVLKLNNNG LGIGGKQIAK SLTECLRKSI
AVGGENRLRL KTFIAGRNRL ENPGAHALAA TFKALETVEW FDVRQNGIHE EGIRALVAAL
KHNRNLRYLW LEDNTVLPKG AKALAKTLES WPKLEVLNLS DCLIRDAGCN YIIDHLNPQH
HRHLKNVYLC GNELTPPVAK LLIQKWSKFD GLTPKPVLHI HTNSFGDEFS DVAGMAPENV
NVGDEDDDLG SLDGDQEEYN SKSSDSEDAD LDDDDEDDDE EAEIQIIDNG ESQLKLAMDR
IDRLDIDFES RFQEDTARVI LQLSAPLKSC KMSEPALQRA IEVAENIVRR VESVKRNPIP
ATTQLVNNIV AQCAGTGVKA ETDWGYGADP QVISRLFSEL VARGHFKLEL ALLQRFFPSQ
