RGPD1_HUMAN
ID RGPD1_HUMAN Reviewed; 1748 AA.
AC P0DJD0; P0C839; Q68DN6; Q6V1X0;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=RANBP2-like and GRIP domain-containing protein 1;
DE AltName: Full=Ran-binding protein 2-like 6;
DE Short=RanBP2-like 6;
DE Short=RanBP2L6;
GN Name=RGPD1; Synonyms=RANBP2L6, RGP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the
CC chromosome 2 centromere.
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DR EMBL; CR749330; CAH18184.1; -; mRNA.
DR EMBL; AC111200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46358.2; -.
DR RefSeq; NP_001019628.3; NM_001024457.3.
DR AlphaFoldDB; P0DJD0; -.
DR SMR; P0DJD0; -.
DR BioGRID; 134847; 42.
DR IntAct; P0DJD0; 7.
DR STRING; 9606.ENSP00000453170; -.
DR iPTMnet; P0DJD0; -.
DR PhosphoSitePlus; P0DJD0; -.
DR SwissPalm; P0DJD0; -.
DR BioMuta; RGPD1; -.
DR DMDM; 374253660; -.
DR EPD; P0DJD0; -.
DR jPOST; P0DJD0; -.
DR MassIVE; P0DJD0; -.
DR MaxQB; P0DJD0; -.
DR PeptideAtlas; P0DJD0; -.
DR PRIDE; P0DJD0; -.
DR Antibodypedia; 71731; 6 antibodies from 6 providers.
DR DNASU; 400966; -.
DR Ensembl; ENST00000409776.6; ENSP00000386808.2; ENSG00000187627.17.
DR GeneID; 400966; -.
DR KEGG; hsa:400966; -.
DR UCSC; uc021vkh.2; human.
DR CTD; 400966; -.
DR DisGeNET; 400966; -.
DR GeneCards; RGPD1; -.
DR HGNC; HGNC:32414; RGPD1.
DR HPA; ENSG00000187627; Group enriched (cervix, placenta, testis).
DR MIM; 612704; gene.
DR neXtProt; NX_P0DJD0; -.
DR VEuPathDB; HostDB:ENSG00000187627; -.
DR eggNOG; KOG0864; Eukaryota.
DR GeneTree; ENSGT00940000164065; -.
DR InParanoid; P0DJD0; -.
DR OrthoDB; 201737at2759; -.
DR PathwayCommons; P0DJD0; -.
DR SignaLink; P0DJD0; -.
DR BioGRID-ORCS; 400966; 52 hits in 950 CRISPR screens.
DR ChiTaRS; RGPD1; human.
DR GenomeRNAi; 400966; -.
DR Pharos; P0DJD0; Tdark.
DR PRO; PR:P0DJD0; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P0DJD0; protein.
DR Bgee; ENSG00000187627; Expressed in right testis and 101 other tissues.
DR ExpressionAtlas; P0DJD0; baseline and differential.
DR Genevisible; P0DJD0; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR032023; GCC2_Rab_bind.
DR InterPro; IPR000237; GRIP_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23138; PTHR23138; 2.
DR Pfam; PF01465; GRIP; 1.
DR Pfam; PF16704; Rab_bind; 1.
DR Pfam; PF00638; Ran_BP1; 2.
DR SMART; SM00755; Grip; 1.
DR SMART; SM00160; RanBD; 2.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50913; GRIP; 1.
DR PROSITE; PS50196; RANBD1; 2.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1748
FT /note="RANBP2-like and GRIP domain-containing protein 1"
FT /id="PRO_0000204919"
FT REPEAT 51..84
FT /note="TPR 1"
FT REPEAT 575..608
FT /note="TPR 2"
FT REPEAT 639..672
FT /note="TPR 3"
FT DOMAIN 1021..1157
FT /note="RanBD1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1318..1454
FT /note="RanBD1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1685..1735
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 751..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1198..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 14
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q99666"
FT CONFLICT 1212
FT /note="A -> S (in Ref. 1; CAH18184)"
FT /evidence="ECO:0000305"
FT CONFLICT 1596
FT /note="Q -> H (in Ref. 1; CAH18184)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1748 AA; 196662 MW; F714EAF3129B388A CRC64;
MNVMGFNTDR LAWTRNKLRG FYFAKLYYEA KEYDLAKKYV CTYLSVQERD PRAHRFLGLL
YELEENTEKA VECYRRSLEL NPPQKDLVLK IAELLCKNDV TDGRAKYWVE RAAKLFPGSP
AIYKLKEHLL DCEGEDGWNK LFDWIQSELY VRPDDVHMNI RLVELYRSNK RLKDAVARCH
EAERNIALRS SLEWNSCVVQ TLKEYLESLQ CLESDKSDWR ATNTDLLLAY ANLMLLTLST
RDVQESRELL ESFDSALQSA KSSLGGNDEL SATFLEMKGH FYMHAGSLLL KMGQHGNNVQ
WQALSELAAL CYVIAFQVPR PKIKLIKGEA GQNLLEMMAC DRLSQSGHML LNLSRGKQDF
LKEVVETFAN KSGQSVLYNA LFSSQSSKDT SFLGSDDIGN IDVQEPELED LARYDVGAIQ
AHNGSLQHLT WLGLQWNSLP ALPGIRKWLK QLFHHLPQET SRLETNAPES ICILDLEVFL
LGVVYTSHLQ LKEKCNSHHS SYQPLCLPLP VCKRLCTERQ KSWWDAVCTL IHRKAVPGNS
AELRLVVQHE INTLRAQEKH GLQPALLVHW AKCLQKMGRG LNSSYDQQEY IGRSVHYWKK
VLPLLKIIKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHITFAILDA VHGNIEDAVT
AFESIKSVVS YWNLALIFHR KAEDIENDAV FPEEQEECKN YLRKTRDYLI KIIDDSDSNL
SVVKKLPVPL ESVKEMLKSV MQELEDYSEG GPLYKNGSLR NADSEIKHST PSPTKYSLSP
SKSYKYSPKT PPRWAEDQNS LRKMICQEVK AITKLNSSKS ASRHRWPTEN YGPDSVPDGY
QGSQTFHGAP LTVATTGPSV YYSQSPAYNS QYLLRPAANV TPTKGSSNTE FKSTKEGFSI
AVSADGFKFG ISEPGNQEKK SEKPLENDTG FQAQDISGQK NGRGVIFGQT SSTFTFADVA
KSTSGEGFQF GKKDPNFKGF SGAGEKLFSS QCGKMANKAN TSGDFEKDDD ACKTEDSDDI
HFEPVVQMPE KVELVTGEEG EKVLYSQGVK LFRFDAEISQ WKERGLGNLK ILKNEVNGKP
RMLMRRDQVL KVCANHWITT TMNLKPLSGS DRAWMWLASD FSDGDAKLER LAAQFKTPEL
AEEFKQKFEE CQRLLLDIPL QTPHKLVDTG RAAKLIQRAE EMKSGLKDFK TFLTNDQTKV
TEEENKGSGT GAAGASDTTI KPNPENTGPT LEWDNYDLRE DALDDNVSSS SVHDSPLASS
PVRKNIFRFD ESTTGFNFSF KSALSLSKSP AKLNQSGTSV GTDEESDVTQ EEERDGQYFE
PVVPLPDLVE VSSGEENEQV VFSHRAELYR YDKDVGQWKE RGIGDIKILQ NYDNKQVRIV
MRRDQVLKLC ANHRITPDMS LQNMKGTERV WVWTACDFAD GERKVEHLAV RFKLQDVADS
FKKIFDEAKT AQEKDSLITP HVSRSSTPRE SPCGKIAVAV LEETTRERTD VIQGDDVADA
ASEVEVSSTS ETTTKAVVSP PKFVFGSESV KRIFSSEKSN PFAFGNSSAT GSLFGFSFNA
PLKSNDSETS SVAQSGSESK VEPKKCELSK NSDIEQSSDS KVKNLSASFP MEESSINYTF
KTPEKEPPLW HAEFTKEELV QKLSSTTKSA DQLNGLLRET EATSAVLMEQ IKLLKSEIRR
LERNQEESAA NVEHLKNVLL QFIFLKPGSE RESLLPVINT MLQLSPEEKG KLAAVAQGLQ
ETSIPKKK
