RGPD2_HUMAN
ID RGPD2_HUMAN Reviewed; 1756 AA.
AC P0DJD1; P0C839; Q68DN6; Q6V1X0;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=RANBP2-like and GRIP domain-containing protein 2;
DE AltName: Full=Ran-binding protein 2-like 2;
DE Short=RanBP2-like 2;
DE Short=RanBP2L2;
GN Name=RGPD2; Synonyms=RANBP2L2, RGP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 660-1756.
RC TISSUE=Testis;
RA Sha J.H., Zhou Z.M., Li J.M.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the
CC chromosome 2 centromere.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ63888.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AC093616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY354203; AAQ63888.1; ALT_SEQ; mRNA.
DR CCDS; CCDS42710.2; -.
DR RefSeq; NP_001071638.2; NM_001078170.2.
DR AlphaFoldDB; P0DJD1; -.
DR SMR; P0DJD1; -.
DR BioGRID; 610251; 35.
DR IntAct; P0DJD1; 7.
DR STRING; 9606.ENSP00000381214; -.
DR iPTMnet; P0DJD1; -.
DR PhosphoSitePlus; P0DJD1; -.
DR BioMuta; RGPD2; -.
DR DMDM; 374253661; -.
DR jPOST; P0DJD1; -.
DR MassIVE; P0DJD1; -.
DR MaxQB; P0DJD1; -.
DR PaxDb; P0DJD1; -.
DR PeptideAtlas; P0DJD1; -.
DR PRIDE; P0DJD1; -.
DR Antibodypedia; 76124; 2 antibodies from 2 providers.
DR Ensembl; ENST00000398146.5; ENSP00000381214.3; ENSG00000185304.16.
DR GeneID; 729857; -.
DR KEGG; hsa:729857; -.
DR MANE-Select; ENST00000398146.5; ENSP00000381214.3; NM_001078170.3; NP_001071638.2.
DR UCSC; uc010fhc.3; human.
DR CTD; 729857; -.
DR DisGeNET; 729857; -.
DR GeneCards; RGPD2; -.
DR HGNC; HGNC:32415; RGPD2.
DR HPA; ENSG00000185304; Tissue enhanced (testis).
DR MIM; 612705; gene.
DR neXtProt; NX_P0DJD1; -.
DR OpenTargets; ENSG00000185304; -.
DR VEuPathDB; HostDB:ENSG00000185304; -.
DR eggNOG; KOG0864; Eukaryota.
DR GeneTree; ENSGT00940000164065; -.
DR HOGENOM; CLU_004100_0_0_1; -.
DR InParanoid; P0DJD1; -.
DR OrthoDB; 201737at2759; -.
DR PhylomeDB; P0DJD1; -.
DR TreeFam; TF314797; -.
DR PathwayCommons; P0DJD1; -.
DR SignaLink; P0DJD1; -.
DR BioGRID-ORCS; 729857; 165 hits in 1004 CRISPR screens.
DR ChiTaRS; RGPD2; human.
DR GenomeRNAi; 729857; -.
DR Pharos; P0DJD1; Tdark.
DR PRO; PR:P0DJD1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P0DJD1; protein.
DR Bgee; ENSG00000185304; Expressed in left testis and 95 other tissues.
DR ExpressionAtlas; P0DJD1; baseline and differential.
DR Genevisible; P0DJD1; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR032023; GCC2_Rab_bind.
DR InterPro; IPR000237; GRIP_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23138; PTHR23138; 2.
DR Pfam; PF01465; GRIP; 1.
DR Pfam; PF16704; Rab_bind; 1.
DR Pfam; PF00638; Ran_BP1; 2.
DR SMART; SM00755; Grip; 1.
DR SMART; SM00160; RanBD; 2.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50913; GRIP; 1.
DR PROSITE; PS50196; RANBD1; 2.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1756
FT /note="RANBP2-like and GRIP domain-containing protein 2"
FT /id="PRO_0000415356"
FT REPEAT 59..92
FT /note="TPR 1"
FT REPEAT 583..616
FT /note="TPR 2"
FT REPEAT 647..680
FT /note="TPR 3"
FT DOMAIN 1029..1165
FT /note="RanBD1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1326..1462
FT /note="RanBD1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1693..1743
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 759..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1206..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1573..1614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99666"
SQ SEQUENCE 1756 AA; 197308 MW; AF734EAD7BBFA429 CRC64;
MRRSKAYGER YLASVQGSAP SPGKKLRGFY FAKLYYEAKE YDLAKKYVCT YLSVQERDPR
AHRFLGLLYE LEENTEKAVE CYRRSLELNP PQKDLVLKIA ELLCKNDVTD GRAKYWVERA
AKLFPGSPAI YKLKEHLLDC EGEDGWNKLF DWIQSELYVR PDDVHMNIRL VELYRSNKRL
KDAVARCHEA ERNIALRSSL EWNSCVVQTL KEYLESLQCL ESDKSDWRAT NTDLLLAYAN
LMLLTLSTRD VQESRELLES FDSALQSAKS SLGGNDELSA TFLEMKGHFY MHAGSLLLKM
GQHGNNVQWQ ALSELAALCY VIAFQVPRPK IKLIKGEAGQ NLLEMMACDR LSQSGHMLLN
LSRGKQDFLK EVVETFANKS GQSVLYNALF SSQSSKDTSF LGSDDIGNID VQEPELEDLA
RYDVGAIQAH NGSLQHLTWL GLQWNSLPAL PGIRKWLKQL FHHLPQETSR LETNAPESIC
ILDLEVFLLG VVYTSHLQLK EKCNSHHSSY QPLCLPLPVC KRLCTERQKS WWDAVCTLIH
RKAVPGNSAE LRLVVQHEIN TLRAQEKHGL QPALLVHWAK CLQKMGRGLN SSYDQQEYIG
RSVHYWKKVL PLLKIIKKNS IPEPIDPLFK HFHSVDIQAS EIVEYEEDAH ITFAILDAVH
GNIEDAVTAF ESIKSVVSYW NLALIFHRKA EDIENDAVFP EEQEECKNYL RKTRDYLIKI
IDDSDSNLSV VKKLPVPLES VKEMLKSVMQ ELEDYSEGGP LYKNGSLRNA DSEIKHSTPS
PTKYSLSPSK SYKYSPKTPP RWAEDQNSLR KMICQEVKAI TKLNSSKSAS RHRWPTENYG
PDSVPDGYQG SQTFHGAPLT VATTGPSVYY SQSPAYNSQY LLRPAANVTP TKGSSNTEFK
STKEGFSIAV SADGFKFGIS EPGNQEKKSE KPLENDTGFQ AQDISGQKNG RGVIFGQTSS
TFTFADVAKS TSGEGFQFGK KDPNFKGFSG AGEKLFSSQC GKMANKANTS GDFEKDDDAC
KTEDSDDIHF EPVVQMPEKV ELVTGEEGEK VLYSQGVKLF RFDAEISQWK ERGLGNLKIL
KNEVNGKPRM LMRRDQVLKV CANHWITTTM NLKPLSGSDR AWMWLASDFS DGDAKLERLA
AQFKTPELAE EFKQKFEECQ RLLLDIPLQT PHKLVDTGRA AKLIQRAEEM KSGLKDFKTF
LTNDQTKVTE EENKGSGTGA AGASDTTIKP NPENTGPTLE WDNYDLREDA LDDNVSSSSV
HDSPLASSPV RKNIFRFDES TTGFNFSFKS ALSLSKSPAK LNQSGTSVGT DEESDVTQEE
ERDGQYFEPV VPLPDLVEVS SGEENEQVVF SHMAELYRYD KDVGQWKERG IGDIKILQNY
DNKQVRIVMR RDQVLKLCAN HRITPDMSLQ NMKGTERVWV WTACDFADGE RKVEHLAVRF
KLQDVADSFK KIFDEAKTAQ EKDSLITPHV SRSSTPRESP CGKIAVAVLE ETTRERTDVI
QGDDVADAAS EVEVSSTSET TTKAVVSPPK FVFGSESVKR IFSSEKSNPF AFGNSSATGS
LFGFSFNAPL KSNDSETSSV AQSGSESKVE PKKCELSKNS DIEQSSDSKV KNLSASFPME
ESSINYTFKT PEKEPPLWHA EFTKEELVQK LSSTTKSADQ LNGLLRETEA TSAVLMEQIK
LLKSEIRRLE RNQEESAANV EHLKNVLLQF IFLKPGSERE SLLPVINTML QLSPEEKGKL
AAVAQGLQET SIPKKK
