RGPD3_HUMAN
ID RGPD3_HUMAN Reviewed; 1758 AA.
AC A6NKT7; B8ZZM4;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=RanBP2-like and GRIP domain-containing protein 3;
GN Name=RGPD3; Synonyms=RGP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1686-1758.
RG The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute;
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP RANBP2 CLUSTER.
RX PubMed=15710750; DOI=10.1101/gr.3266405;
RA Ciccarelli F.D., von Mering C., Suyama M., Harrington E.D., Izaurralde E.,
RA Bork P.;
RT "Complex genomic rearrangements lead to novel primate gene function.";
RL Genome Res. 15:343-351(2005).
CC -!- MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the
CC chromosome 2 centromere.
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DR EMBL; AC097527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC114755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46379.1; -.
DR RefSeq; NP_001137485.1; NM_001144013.1.
DR AlphaFoldDB; A6NKT7; -.
DR SMR; A6NKT7; -.
DR BioGRID; 575821; 41.
DR IntAct; A6NKT7; 14.
DR MINT; A6NKT7; -.
DR STRING; 9606.ENSP00000386588; -.
DR iPTMnet; A6NKT7; -.
DR PhosphoSitePlus; A6NKT7; -.
DR BioMuta; RGPD3; -.
DR EPD; A6NKT7; -.
DR jPOST; A6NKT7; -.
DR MassIVE; A6NKT7; -.
DR MaxQB; A6NKT7; -.
DR PaxDb; A6NKT7; -.
DR PeptideAtlas; A6NKT7; -.
DR PRIDE; A6NKT7; -.
DR ProteomicsDB; 1430; -.
DR DNASU; 653489; -.
DR Ensembl; ENST00000409886.4; ENSP00000386588.4; ENSG00000153165.19.
DR GeneID; 653489; -.
DR KEGG; hsa:653489; -.
DR MANE-Select; ENST00000409886.4; ENSP00000386588.4; NM_001144013.2; NP_001137485.1.
DR UCSC; uc010ywi.2; human.
DR CTD; 653489; -.
DR GeneCards; RGPD3; -.
DR HGNC; HGNC:32416; RGPD3.
DR HPA; ENSG00000153165; Tissue enhanced (testis).
DR MIM; 612706; gene.
DR neXtProt; NX_A6NKT7; -.
DR PharmGKB; PA142671072; -.
DR VEuPathDB; HostDB:ENSG00000153165; -.
DR eggNOG; KOG0864; Eukaryota.
DR GeneTree; ENSGT00940000164065; -.
DR HOGENOM; CLU_004100_0_0_1; -.
DR InParanoid; A6NKT7; -.
DR OrthoDB; 201737at2759; -.
DR PhylomeDB; A6NKT7; -.
DR TreeFam; TF314797; -.
DR PathwayCommons; A6NKT7; -.
DR SignaLink; A6NKT7; -.
DR BioGRID-ORCS; 653489; 15 hits in 640 CRISPR screens.
DR ChiTaRS; RGPD3; human.
DR GenomeRNAi; 653489; -.
DR Pharos; A6NKT7; Tdark.
DR PRO; PR:A6NKT7; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A6NKT7; protein.
DR Bgee; ENSG00000153165; Expressed in calcaneal tendon and 93 other tissues.
DR ExpressionAtlas; A6NKT7; baseline and differential.
DR Genevisible; A6NKT7; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR032023; GCC2_Rab_bind.
DR InterPro; IPR000237; GRIP_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23138; PTHR23138; 2.
DR Pfam; PF01465; GRIP; 1.
DR Pfam; PF16704; Rab_bind; 1.
DR Pfam; PF00638; Ran_BP1; 2.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00755; Grip; 1.
DR SMART; SM00160; RanBD; 2.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50913; GRIP; 1.
DR PROSITE; PS50196; RANBD1; 2.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1758
FT /note="RanBP2-like and GRIP domain-containing protein 3"
FT /id="PRO_0000340666"
FT REPEAT 60..93
FT /note="TPR 1"
FT REPEAT 584..617
FT /note="TPR 2"
FT DOMAIN 1037..1173
FT /note="RanBD1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1334..1470
FT /note="RanBD1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1703..1753
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 761..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1581..1622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 176..229
FT /evidence="ECO:0000255"
FT COILED 805..837
FT /evidence="ECO:0000255"
FT COMPBIAS 773..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99666"
SQ SEQUENCE 1758 AA; 197487 MW; 76CCC1934CCD6E48 CRC64;
MSCSKAYGER YVASVQGSAP SPRKKSTRGF YFAKLYYEAK EYDLAKKYIC TYINVREMDP
RAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAEYWVER
AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR
LKDAVARCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA
NLMLLTLSTR DVQESRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMHAGSLLLK
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLIKGEAG QNLLEMMACD RLSQSGHMLL
NLSRGKQDFL KVVVETFANK SGQSALYDAL FSSQSPKDTS FLGSDDIGNI DVQEPELEDL
ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHHLPQETS RLETNAPESI
CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPLPV CKQLCTERQK SWWDAVCTLI
HRKAVPGNSA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KCLQKMGSGL NSFYDQREYI
GRSVHYWKKV LPLLKIIKKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHVTFAILDA
VNGNIEDAMT AFESIKSVVS YWNLALIFHR KAEDIANDAL SPEEQEECKN YLRKTRGYLI
KILDDSDSNL SVVKKLPVPL ESVKEMLKSV MQELENYSEG GPLYKNGSLR NADSEIKHST
PSPTKYSLSP SKSYKYSPKT PPRWAEDQNS LLKMIRQEVK AIKEEMQELK LNSSKSASHH
RWPTENYGPD SVPDGYQGSQ TFHGAPLTVA TTGPSVYYSQ SPAYNSQYLL RPAANVTPTK
GSSNTEFKST KEGFSIPVSA DGFKFGISEP GNQEKKSEKP LENDTGLQAQ DISGRKKGRG
VIFGQTSSTF TFADVAKSTS GEGFQFGKKD LNFKGFSGAG EKLFSSQYGK MANKANTSGD
FEKDDDAYKT EDSDDIHFEP VVQMPEKVEL VTGEEGEKVL YSQGVKLFRF DAEVSQWKER
GLGNLKILKN EVNGKVRMLM QREQVLKVCA NHWITTTMNL KPLSGSDRAW MWSASDFSDG
DAKLERLAAK FKTPELAEEF KQKFEECQRL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS
GLKDFKTFLT NDQTKVAEEE NKGSGTGAAG ASDTTIKPNA ENTGPTLEWD NYDLREDALD
DSVSSSSVHA SPLASSPVRK NLFHFDESTT GSNFSFKSAL SLSKSPAKLN QSGTSVGTDE
ESDVTQEEER DGQYFEPVVP LPDLVEVSSG EENEQVVFSH RAEFYRYDKD VGQWKERGIG
DIKILQNYDN KHVRILMRRD QVLKLCANHR ITPDMSLQNM KGTERVWVWT ACDFADGERK
VEHLAVRFKL QDVADSFKKI FDEAKTAQEK DSLITPHVSR SSTPRESPCG KIAVAVLEET
TRERTDVIQG DDVADAASEV EVSSTSETTT KAVVSPPKFV FGSESVKRIF SSEKSKPFAF
GNSSATGSLF GFSFNAPLKS NNSETSSVAQ SGSESKVEPK KCELSKNSDI EQSSDSKVKN
LSASFPTEES SINYTFKTPE KEPPLWYAEF TKEELVQKLS STTKSADHLN GLLREIEATN
AVLMEQIKLL KSEIRRLERN QEQEVSAANV EHLKNVLLQF IFLKPGSERE RLLPVINTML
QLSLEEKGKL AAVAQGEE
