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RGPD4_HUMAN
ID   RGPD4_HUMAN             Reviewed;        1758 AA.
AC   Q7Z3J3; B9A029;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 3.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=RanBP2-like and GRIP domain-containing protein 4;
GN   Name=RGPD4; Synonyms=RGP4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Retina;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   RANBP2 CLUSTER.
RX   PubMed=15710750; DOI=10.1101/gr.3266405;
RA   Ciccarelli F.D., von Mering C., Suyama M., Harrington E.D., Izaurralde E.,
RA   Bork P.;
RT   "Complex genomic rearrangements lead to novel primate gene function.";
RL   Genome Res. 15:343-351(2005).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7Z3J3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7Z3J3-2; Sequence=VSP_030214, VSP_030215;
CC   -!- MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the
CC       chromosome 2 centromere.
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DR   EMBL; BX537861; CAD97866.1; -; mRNA.
DR   EMBL; AC009963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC096655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46381.1; -. [Q7Z3J3-1]
DR   RefSeq; NP_872394.2; NM_182588.2. [Q7Z3J3-1]
DR   AlphaFoldDB; Q7Z3J3; -.
DR   SMR; Q7Z3J3; -.
DR   BioGRID; 130039; 11.
DR   IntAct; Q7Z3J3; 3.
DR   STRING; 9606.ENSP00000386810; -.
DR   GlyConnect; 2898; 1 O-Linked glycan (1 site).
DR   GlyGen; Q7Z3J3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q7Z3J3; -.
DR   PhosphoSitePlus; Q7Z3J3; -.
DR   BioMuta; RGPD4; -.
DR   DMDM; 325511381; -.
DR   EPD; Q7Z3J3; -.
DR   jPOST; Q7Z3J3; -.
DR   MassIVE; Q7Z3J3; -.
DR   MaxQB; Q7Z3J3; -.
DR   PaxDb; Q7Z3J3; -.
DR   PeptideAtlas; Q7Z3J3; -.
DR   PRIDE; Q7Z3J3; -.
DR   ProteomicsDB; 69057; -. [Q7Z3J3-1]
DR   DNASU; 285190; -.
DR   Ensembl; ENST00000408999.4; ENSP00000386810.4; ENSG00000196862.10. [Q7Z3J3-1]
DR   GeneID; 285190; -.
DR   KEGG; hsa:285190; -.
DR   MANE-Select; ENST00000408999.4; ENSP00000386810.4; NM_182588.3; NP_872394.2.
DR   UCSC; uc010ywk.3; human. [Q7Z3J3-1]
DR   CTD; 285190; -.
DR   GeneCards; RGPD4; -.
DR   HGNC; HGNC:32417; RGPD4.
DR   HPA; ENSG00000196862; Tissue enhanced (testis).
DR   MIM; 612707; gene.
DR   neXtProt; NX_Q7Z3J3; -.
DR   OpenTargets; ENSG00000196862; -.
DR   PharmGKB; PA142671073; -.
DR   VEuPathDB; HostDB:ENSG00000196862; -.
DR   eggNOG; KOG0864; Eukaryota.
DR   GeneTree; ENSGT00940000164065; -.
DR   HOGENOM; CLU_004100_0_0_1; -.
DR   InParanoid; Q7Z3J3; -.
DR   OMA; REETHED; -.
DR   OrthoDB; 1573143at2759; -.
DR   PhylomeDB; Q7Z3J3; -.
DR   TreeFam; TF314797; -.
DR   PathwayCommons; Q7Z3J3; -.
DR   SignaLink; Q7Z3J3; -.
DR   BioGRID-ORCS; 285190; 38 hits in 990 CRISPR screens.
DR   GenomeRNAi; 285190; -.
DR   Pharos; Q7Z3J3; Tdark.
DR   PRO; PR:Q7Z3J3; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q7Z3J3; protein.
DR   Bgee; ENSG00000196862; Expressed in testis and 84 other tissues.
DR   Genevisible; Q7Z3J3; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR032023; GCC2_Rab_bind.
DR   InterPro; IPR000237; GRIP_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000156; Ran_bind_dom.
DR   InterPro; IPR045255; RanBP1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR23138; PTHR23138; 2.
DR   Pfam; PF01465; GRIP; 1.
DR   Pfam; PF16704; Rab_bind; 1.
DR   Pfam; PF00638; Ran_BP1; 2.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00755; Grip; 1.
DR   SMART; SM00160; RanBD; 2.
DR   SMART; SM00028; TPR; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50913; GRIP; 1.
DR   PROSITE; PS50196; RANBD1; 2.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW   TPR repeat.
FT   CHAIN           1..1758
FT                   /note="RanBP2-like and GRIP domain-containing protein 4"
FT                   /id="PRO_0000314141"
FT   REPEAT          60..93
FT                   /note="TPR 1"
FT   REPEAT          584..617
FT                   /note="TPR 2"
FT   DOMAIN          1037..1173
FT                   /note="RanBD1 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT   DOMAIN          1334..1470
FT                   /note="RanBD1 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT   DOMAIN          1703..1753
FT                   /note="GRIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT   REGION          761..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1213..1249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1295..1332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1583..1621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        773..796
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1227..1246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1295..1320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1596..1613
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         21
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99666"
FT   VAR_SEQ         1..57
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_030214"
FT   VAR_SEQ         213..1758
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_030215"
SQ   SEQUENCE   1758 AA;  197289 MW;  03C915030A2F1BD3 CRC64;
     MSCSKAYGER YVASVQGSAP SPRKKSTRGF YFAKLYYEAK EYDLAKKYIC TYINVREMDP
     RAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER
     AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR
     LKDAVARCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA
     NLMLLTLSTR DVQESRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMHAGSLLLK
     MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLIKGEAG QNLLEMMACD RLSQSGHMLL
     NLSRGKQDFL KVVVETFANK SGQSALYDAL FSSQSPKDTS FLGSDDIGNI DVQEPELEDL
     ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHHLPQETS RLETNAPESI
     CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPLPV CKQLCTERQK SWWDAVCTLI
     HRKAVPGNSA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KCLQKMGSGL NSFYDQREYI
     GRSVHYWKKV LPLLKIIKKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHVTFAILDA
     VNGNIEDAMT AFESIKSVVS YWNLALIFHR KAEDIANDAL SPEEQEECKN YLRKTRGYLI
     KILDDSDSNL SVVKKLPVPL ESVKEMLKSV MQELENYSEG DPLYKNGSLR NADSEIKHST
     PSPTKYSLSP SKSYKYSPKT PPRWAEDQNS LLKMIRQEVK AIKEEMQELK LNSSKSASHH
     RWPTENYGPD SVPDGYQGSQ TFHGAPLTVA TTGPSVYYSQ SPAYNSQYLL RPAANVTPTK
     GSSNTEFKST KEGFSIPVSA DGFKFGISEP GNQEKESEKP LENDTGFQAQ DISGQKNGRG
     VIFGQTSSTF TFADVAKSTS GEGFQFGKKD PNFKGFSGAG EKLFSSQCGK MANKANTSGD
     FEKDDDAYKT EDSDDIHFEP VVQMPEKVEL VIGEEGEKVL YSQGVKLFRF DAEVRQWKER
     GLGNLKILKN EVNGKPRMLM RREQVLKVCA NHWITTTMNL KPLSGSDRAW MWSASDFSDG
     DAKLERLAAK FKTPELAEEF KQKFEECQQL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS
     GLKDFKTFLT NDQTKVTEEE NKGSGTGAAG ASDTTIKPNP ENTGPTLEWD NCDLREDALD
     DSVSSSSVHA SPLASSPVRK NLFHFGESTT GSNFSFKSAL SPSKSPAKLN QSGTSVGTDE
     ESDVTQEEER DGQYFEPVVP LPDLVEVSSG EENEKVVFSH RAELYRYDKD VGQWKERGIG
     DIKILQNYDN KQVRIVMRRD QVLKLCANHT ITPDMSLQNM KGTERVWVWT ACDFADGERK
     VEHLAVRFKL QDVADSFKKI FDEAKTAQEK DSLITPHVSR SSTPRESPCG KIAVAVLEET
     TRERTDVIQG DDVADAASEV EVSSTSETTT KAVVSPPKFV FGSESVKRIF SSEKSKPFAF
     GNSSATGSLF GFSFNASLKS NNSETSSVAQ SGSESKVEPK KCELSKNSDI EQSSDSKVKN
     LSASFPMEES SINYTFKTPE KEPPLWHAEF TKEELVQKLS STTKSADHLN GLLREAEATS
     AVLMEQIKLL KSEIRRLERN QEQEESAANV EHLKNVLLQF IFLKPGSERE RLLPVINTML
     QLSPEEKGKL AAVAQGEE
 
 
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