RGPD4_HUMAN
ID RGPD4_HUMAN Reviewed; 1758 AA.
AC Q7Z3J3; B9A029;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 3.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=RanBP2-like and GRIP domain-containing protein 4;
GN Name=RGPD4; Synonyms=RGP4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP RANBP2 CLUSTER.
RX PubMed=15710750; DOI=10.1101/gr.3266405;
RA Ciccarelli F.D., von Mering C., Suyama M., Harrington E.D., Izaurralde E.,
RA Bork P.;
RT "Complex genomic rearrangements lead to novel primate gene function.";
RL Genome Res. 15:343-351(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z3J3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z3J3-2; Sequence=VSP_030214, VSP_030215;
CC -!- MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the
CC chromosome 2 centromere.
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DR EMBL; BX537861; CAD97866.1; -; mRNA.
DR EMBL; AC009963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC096655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46381.1; -. [Q7Z3J3-1]
DR RefSeq; NP_872394.2; NM_182588.2. [Q7Z3J3-1]
DR AlphaFoldDB; Q7Z3J3; -.
DR SMR; Q7Z3J3; -.
DR BioGRID; 130039; 11.
DR IntAct; Q7Z3J3; 3.
DR STRING; 9606.ENSP00000386810; -.
DR GlyConnect; 2898; 1 O-Linked glycan (1 site).
DR GlyGen; Q7Z3J3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q7Z3J3; -.
DR PhosphoSitePlus; Q7Z3J3; -.
DR BioMuta; RGPD4; -.
DR DMDM; 325511381; -.
DR EPD; Q7Z3J3; -.
DR jPOST; Q7Z3J3; -.
DR MassIVE; Q7Z3J3; -.
DR MaxQB; Q7Z3J3; -.
DR PaxDb; Q7Z3J3; -.
DR PeptideAtlas; Q7Z3J3; -.
DR PRIDE; Q7Z3J3; -.
DR ProteomicsDB; 69057; -. [Q7Z3J3-1]
DR DNASU; 285190; -.
DR Ensembl; ENST00000408999.4; ENSP00000386810.4; ENSG00000196862.10. [Q7Z3J3-1]
DR GeneID; 285190; -.
DR KEGG; hsa:285190; -.
DR MANE-Select; ENST00000408999.4; ENSP00000386810.4; NM_182588.3; NP_872394.2.
DR UCSC; uc010ywk.3; human. [Q7Z3J3-1]
DR CTD; 285190; -.
DR GeneCards; RGPD4; -.
DR HGNC; HGNC:32417; RGPD4.
DR HPA; ENSG00000196862; Tissue enhanced (testis).
DR MIM; 612707; gene.
DR neXtProt; NX_Q7Z3J3; -.
DR OpenTargets; ENSG00000196862; -.
DR PharmGKB; PA142671073; -.
DR VEuPathDB; HostDB:ENSG00000196862; -.
DR eggNOG; KOG0864; Eukaryota.
DR GeneTree; ENSGT00940000164065; -.
DR HOGENOM; CLU_004100_0_0_1; -.
DR InParanoid; Q7Z3J3; -.
DR OMA; REETHED; -.
DR OrthoDB; 1573143at2759; -.
DR PhylomeDB; Q7Z3J3; -.
DR TreeFam; TF314797; -.
DR PathwayCommons; Q7Z3J3; -.
DR SignaLink; Q7Z3J3; -.
DR BioGRID-ORCS; 285190; 38 hits in 990 CRISPR screens.
DR GenomeRNAi; 285190; -.
DR Pharos; Q7Z3J3; Tdark.
DR PRO; PR:Q7Z3J3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q7Z3J3; protein.
DR Bgee; ENSG00000196862; Expressed in testis and 84 other tissues.
DR Genevisible; Q7Z3J3; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR032023; GCC2_Rab_bind.
DR InterPro; IPR000237; GRIP_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23138; PTHR23138; 2.
DR Pfam; PF01465; GRIP; 1.
DR Pfam; PF16704; Rab_bind; 1.
DR Pfam; PF00638; Ran_BP1; 2.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00755; Grip; 1.
DR SMART; SM00160; RanBD; 2.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50913; GRIP; 1.
DR PROSITE; PS50196; RANBD1; 2.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..1758
FT /note="RanBP2-like and GRIP domain-containing protein 4"
FT /id="PRO_0000314141"
FT REPEAT 60..93
FT /note="TPR 1"
FT REPEAT 584..617
FT /note="TPR 2"
FT DOMAIN 1037..1173
FT /note="RanBD1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1334..1470
FT /note="RanBD1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1703..1753
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 761..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1295..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99666"
FT VAR_SEQ 1..57
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_030214"
FT VAR_SEQ 213..1758
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_030215"
SQ SEQUENCE 1758 AA; 197289 MW; 03C915030A2F1BD3 CRC64;
MSCSKAYGER YVASVQGSAP SPRKKSTRGF YFAKLYYEAK EYDLAKKYIC TYINVREMDP
RAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER
AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR
LKDAVARCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA
NLMLLTLSTR DVQESRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMHAGSLLLK
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLIKGEAG QNLLEMMACD RLSQSGHMLL
NLSRGKQDFL KVVVETFANK SGQSALYDAL FSSQSPKDTS FLGSDDIGNI DVQEPELEDL
ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHHLPQETS RLETNAPESI
CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPLPV CKQLCTERQK SWWDAVCTLI
HRKAVPGNSA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KCLQKMGSGL NSFYDQREYI
GRSVHYWKKV LPLLKIIKKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHVTFAILDA
VNGNIEDAMT AFESIKSVVS YWNLALIFHR KAEDIANDAL SPEEQEECKN YLRKTRGYLI
KILDDSDSNL SVVKKLPVPL ESVKEMLKSV MQELENYSEG DPLYKNGSLR NADSEIKHST
PSPTKYSLSP SKSYKYSPKT PPRWAEDQNS LLKMIRQEVK AIKEEMQELK LNSSKSASHH
RWPTENYGPD SVPDGYQGSQ TFHGAPLTVA TTGPSVYYSQ SPAYNSQYLL RPAANVTPTK
GSSNTEFKST KEGFSIPVSA DGFKFGISEP GNQEKESEKP LENDTGFQAQ DISGQKNGRG
VIFGQTSSTF TFADVAKSTS GEGFQFGKKD PNFKGFSGAG EKLFSSQCGK MANKANTSGD
FEKDDDAYKT EDSDDIHFEP VVQMPEKVEL VIGEEGEKVL YSQGVKLFRF DAEVRQWKER
GLGNLKILKN EVNGKPRMLM RREQVLKVCA NHWITTTMNL KPLSGSDRAW MWSASDFSDG
DAKLERLAAK FKTPELAEEF KQKFEECQQL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS
GLKDFKTFLT NDQTKVTEEE NKGSGTGAAG ASDTTIKPNP ENTGPTLEWD NCDLREDALD
DSVSSSSVHA SPLASSPVRK NLFHFGESTT GSNFSFKSAL SPSKSPAKLN QSGTSVGTDE
ESDVTQEEER DGQYFEPVVP LPDLVEVSSG EENEKVVFSH RAELYRYDKD VGQWKERGIG
DIKILQNYDN KQVRIVMRRD QVLKLCANHT ITPDMSLQNM KGTERVWVWT ACDFADGERK
VEHLAVRFKL QDVADSFKKI FDEAKTAQEK DSLITPHVSR SSTPRESPCG KIAVAVLEET
TRERTDVIQG DDVADAASEV EVSSTSETTT KAVVSPPKFV FGSESVKRIF SSEKSKPFAF
GNSSATGSLF GFSFNASLKS NNSETSSVAQ SGSESKVEPK KCELSKNSDI EQSSDSKVKN
LSASFPMEES SINYTFKTPE KEPPLWHAEF TKEELVQKLS STTKSADHLN GLLREAEATS
AVLMEQIKLL KSEIRRLERN QEQEESAANV EHLKNVLLQF IFLKPGSERE RLLPVINTML
QLSPEEKGKL AAVAQGEE