RGPD5_HUMAN
ID RGPD5_HUMAN Reviewed; 1765 AA.
AC Q99666; Q53QN2; Q53T03; Q59GM7; Q9H0B2;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=RANBP2-like and GRIP domain-containing protein 5/6;
DE AltName: Full=Ran-binding protein 2-like 1/2;
DE Short=RanBP2-like 1/2;
DE Short=RanBP2L1;
DE Short=RanBP2L2;
DE AltName: Full=Sperm membrane protein BS-63;
GN Name=RGPD5; Synonyms=RANBP2L1, RGP5, RGP7, RGPD7;
GN and
GN Name=RGPD6; Synonyms=RANBP2L2, RGP6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=10101573; DOI=10.1080/014850199262904;
RA Wang L.F., Zhu H.D., Miao S.Y., Cao D.F., Wu Y.W., Zong S.D., Koide S.S.;
RT "Molecular cloning and characterization of a novel testis-specific
RT nucleoporin-related gene.";
RL Arch. Androl. 42:71-84(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1009-1765 (ISOFORM 1).
RC TISSUE=Brain;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=15710750; DOI=10.1101/gr.3266405;
RA Ciccarelli F.D., von Mering C., Suyama M., Harrington E.D., Izaurralde E.,
RA Bork P.;
RT "Complex genomic rearrangements lead to novel primate gene function.";
RL Genome Res. 15:343-351(2005).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19 AND SER-21, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15710750}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q99666-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99666-2; Sequence=VSP_038968, VSP_038969;
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:10101573}.
CC -!- MISCELLANEOUS: One of the 8 copies of RANBP2 clustered close to the
CC chromosome 2 centromere.
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DR EMBL; U64675; AAB41848.2; -; mRNA.
DR EMBL; AL136868; CAB66802.1; -; mRNA.
DR EMBL; AC013271; AAY14902.1; -; Genomic_DNA.
DR EMBL; AC123886; AAY14839.1; -; Genomic_DNA.
DR EMBL; AC108938; AAY24132.1; -; Genomic_DNA.
DR EMBL; AC109815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB209082; BAD92319.1; -; mRNA.
DR CCDS; CCDS2082.1; -. [Q99666-1]
DR CCDS; CCDS2083.1; -. [Q99666-2]
DR CCDS; CCDS42729.1; -. [Q99666-2]
DR CCDS; CCDS46388.1; -. [Q99666-1]
DR RefSeq; NP_001032955.1; NM_001037866.1. [Q99666-2]
DR RefSeq; NP_001116835.1; NM_001123363.3. [Q99666-1]
DR RefSeq; NP_005045.2; NM_005054.2. [Q99666-1]
DR RefSeq; NP_115636.1; NM_032260.2. [Q99666-2]
DR AlphaFoldDB; Q99666; -.
DR SMR; Q99666; -.
DR BioGRID; 123954; 141.
DR BioGRID; 609938; 29.
DR IntAct; Q99666; 40.
DR MINT; Q99666; -.
DR STRING; 9606.ENSP00000016946; -.
DR iPTMnet; Q99666; -.
DR PhosphoSitePlus; Q99666; -.
DR BioMuta; RGPD5; -.
DR DMDM; 229463026; -.
DR EPD; Q99666; -.
DR jPOST; Q99666; -.
DR MassIVE; Q99666; -.
DR MaxQB; Q99666; -.
DR PaxDb; Q99666; -.
DR PeptideAtlas; Q99666; -.
DR PRIDE; Q99666; -.
DR ProteomicsDB; 78386; -. [Q99666-1]
DR ProteomicsDB; 78387; -. [Q99666-2]
DR Antibodypedia; 33171; 71 antibodies from 24 providers.
DR Antibodypedia; 58593; 9 antibodies from 2 providers.
DR DNASU; 84220; -.
DR Ensembl; ENST00000016946.8; ENSP00000016946.3; ENSG00000015568.13. [Q99666-1]
DR Ensembl; ENST00000272454.10; ENSP00000272454.6; ENSG00000015568.13. [Q99666-2]
DR Ensembl; ENST00000329516.8; ENSP00000330842.3; ENSG00000183054.12. [Q99666-1]
DR Ensembl; ENST00000330331.9; ENSP00000330023.5; ENSG00000183054.12. [Q99666-2]
DR Ensembl; ENST00000393283.5; ENSP00000376962.1; ENSG00000015568.13. [Q99666-2]
DR GeneID; 729540; -.
DR GeneID; 84220; -.
DR KEGG; hsa:729540; -.
DR KEGG; hsa:84220; -.
DR MANE-Select; ENST00000016946.8; ENSP00000016946.3; NM_005054.3; NP_005045.2.
DR MANE-Select; ENST00000329516.8; ENSP00000330842.3; NM_001123363.4; NP_001116835.1.
DR UCSC; uc002tfc.3; human. [Q99666-1]
DR CTD; 729540; -.
DR CTD; 84220; -.
DR GeneCards; RGPD5; -.
DR GeneCards; RGPD6; -.
DR HGNC; HGNC:32418; RGPD5.
DR HGNC; HGNC:32419; RGPD6.
DR HPA; ENSG00000015568; Low tissue specificity.
DR HPA; ENSG00000183054; Low tissue specificity.
DR MIM; 612708; gene.
DR MIM; 612709; gene.
DR MIM; 612710; gene.
DR neXtProt; NX_Q99666; -.
DR OpenTargets; ENSG00000015568; -.
DR PharmGKB; PA142671074; -.
DR VEuPathDB; HostDB:ENSG00000015568; -.
DR VEuPathDB; HostDB:ENSG00000183054; -.
DR eggNOG; KOG0864; Eukaryota.
DR GeneTree; ENSGT00940000164065; -.
DR HOGENOM; CLU_022433_0_0_1; -.
DR InParanoid; Q99666; -.
DR OMA; ACQNPNK; -.
DR OrthoDB; 201737at2759; -.
DR PhylomeDB; Q99666; -.
DR TreeFam; TF314797; -.
DR PathwayCommons; Q99666; -.
DR SignaLink; Q99666; -.
DR BioGRID-ORCS; 729540; 699 hits in 944 CRISPR screens.
DR BioGRID-ORCS; 84220; 32 hits in 251 CRISPR screens.
DR ChiTaRS; RGPD5; human.
DR ChiTaRS; RGPD6; human.
DR GeneWiki; RGPD5; -.
DR Pharos; Q99666; Tbio.
DR PRO; PR:Q99666; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q99666; protein.
DR Bgee; ENSG00000015568; Expressed in calcaneal tendon and 181 other tissues.
DR ExpressionAtlas; Q99666; baseline and differential.
DR Genevisible; Q99666; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR032023; GCC2_Rab_bind.
DR InterPro; IPR000237; GRIP_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23138; PTHR23138; 2.
DR Pfam; PF01465; GRIP; 1.
DR Pfam; PF16704; Rab_bind; 1.
DR Pfam; PF00638; Ran_BP1; 2.
DR SMART; SM00755; Grip; 1.
DR SMART; SM00160; RanBD; 2.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50913; GRIP; 1.
DR PROSITE; PS50196; RANBD1; 2.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..1765
FT /note="RANBP2-like and GRIP domain-containing protein 5/6"
FT /id="PRO_0000204915"
FT REPEAT 26..59
FT /note="TPR 1"
FT REPEAT 60..93
FT /note="TPR 2"
FT REPEAT 648..681
FT /note="TPR 3"
FT DOMAIN 1036..1172
FT /note="RanBD1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1333..1469
FT /note="RanBD1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00164"
FT DOMAIN 1702..1752
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 760..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1580..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1595..1612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 868..904
FT /note="VATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNT -> EAAHRHFTIEK
FT HGDSKWIIYRFTKQLCGTERARAKIS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_038968"
FT VAR_SEQ 905..1765
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_038969"
FT CONFLICT 174
FT /note="L -> V (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="N -> H (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 214
FT /note="Y -> H (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="Q -> R (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 257
FT /note="E -> G (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="K -> E (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 451
FT /note="L -> S (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 736
FT /note="P -> S (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 784
FT /note="K -> R (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 893
FT /note="A -> G (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 905
FT /note="E -> D (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 946
FT /note="F -> L (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 1074
FT /note="R -> S (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 1135
FT /note="D -> H (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 1612
FT /note="S -> P (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
FT CONFLICT 1682
FT /note="L -> P (in Ref. 1; AAB41848)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1765 AA; 198924 MW; DC699DC82C67749D CRC64;
MRRSKADVER YVASVLGLTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP
KAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER
AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR
LKDAVAHCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWQA TNTDLLLAYA
NLMLLTLSTR DVQENRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMYAGSLLLK
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLREGKAG QNLLEMMACD RLSQSGHMLL
SLSRGKQDFL KEVVETFANK IGQSALYDAL FSSQSPKDTS FLGSDDIGKI DVQEPELEDL
ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHRLPHETS RLETNAPESI
CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPFPV CKQLCTERQK SWWDAVCTLI
HRKAVPGNLA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KYLQKTGSGL NSFYGQLEYI
GRSVHYWKKV LPLLKIIKKN SIPEPIDPLF KHFHSVDIQA SEIVEYEEDA HITFAMLDAV
NGNIEDAVTA FESIKSVVSY WNLALIFHRK AEDIENDALS PEEQEECRNY LTKTRDYLIK
IIDDGDSNLS VVKKLPVPLE SVKQMLNSVM QELEDYSEGG PLYKNGSLRN ADSEIKHSTP
SPTKYSLSPS KSYKYSPETP PRWTEDRNSL LNMICQQVEA IKKEMQELKL NSSKSASRHR
WPTENYGPDS VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG
SSNTEFKSTK EGFSIPVSAD GFKFGISEPG NQEKKREKPL ENDTGFQAQD ISGRKKGRGV
IFGQTSSTFT FADVAKSTSG EGFQFGKKDL NFKGFSGAGE KLFSSRYGKM ANKANTSGDF
EKDDDAYKTE DSDDIHFEPV VQMPEKVELV TGEEGEKVLY SQGVKLFRFD AEVRQWKERG
LGNLKILKNE VNGKLRMLMR REQVLKVCAN HWITTTMNLK PLSGSDRAWM WSASDFSDGD
AKLERLAAKF KTPELAEEFK QKFEECQRLL LDIPLQTPHK LVDTGRAAKL IQRAEEMKSG
LKDFKTFLTN DQTKVTEEEN KGSGTGAAGA SDTTIKPNAE NTGPTLEWDN YDLREDALDD
SVSSSSVHAS PLASSPVRKN LFRFDESTTG SNFSFKSALS LSKSPAKLNQ SGTSVGTDEE
SVVTQEEERD GQYFEPVVPL PDLVEVSSGE ENEQVVFSHR AEIYRYDKDV GQWKERGIGD
IKILQNYDNK QVRIVMRRDQ VLKLCANHRI TPDMSLQNMK GTERVWVWTA CDFADGERKV
EHLAVRFKLQ DVADSFKKIF DEAKTAQEKD SLITPHVSRS STPRESPCGK IAVAILEETT
RERTDVIQGD DVADAASEVE VSSTSETTTK AVVSPPKFVF VSESVKRIFS SEKSKPFVFG
NSSATGSLFG FSFNAPLKSN NSETSSVAQS GSESKVEPKK CELSKNSDIE QSSDSKVKNL
SASFPTEESS INYTFKTPEK EPPLWHAEFT KEELVQKLRS TTKSADHLNG LLREIEATNA
VLMEQIKLLK SEIRRLERNQ EREKSAANLE YLKNVLLQFI FLKPGSERER LLPVINTMLQ
LSPEEKGKLA AVAQDEEENA SRSSG
