ID   RGPS1_CHICK             Reviewed;         584 AA.
AC   Q5ZJK0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Ras-specific guanine nucleotide-releasing factor RalGPS1;
DE   AltName: Full=Ral GEF with PH domain and SH3-binding motif 1;
DE   AltName: Full=RalA exchange factor RalGPS1;
GN   Name=RALGPS1; ORFNames=RCJMB04_17i24;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Guanine nucleotide exchange factor. May be involved in
CC       cytoskeletal organization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}. Note=Associated with membranes through the PH domain.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The PH domain mediates binding to membranes. {ECO:0000250}.
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DR   EMBL; AJ720434; CAG32093.1; -; mRNA.
DR   RefSeq; NP_001006532.1; NM_001006532.1.
DR   RefSeq; XP_015145772.1; XM_015290286.1.
DR   AlphaFoldDB; Q5ZJK0; -.
DR   SMR; Q5ZJK0; -.
DR   STRING; 9031.ENSGALP00000006783; -.
DR   PaxDb; Q5ZJK0; -.
DR   Ensembl; ENSGALT00000006794; ENSGALP00000006783; ENSGALG00000004273.
DR   GeneID; 424429; -.
DR   KEGG; gga:424429; -.
DR   CTD; 55103; -.
DR   VEuPathDB; HostDB:geneid_424429; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   GeneTree; ENSGT00940000154079; -.
DR   HOGENOM; CLU_021333_0_1_1; -.
DR   InParanoid; Q5ZJK0; -.
DR   OMA; HVSFWTV; -.
DR   OrthoDB; 343666at2759; -.
DR   PhylomeDB; Q5ZJK0; -.
DR   TreeFam; TF352150; -.
DR   PRO; PR:Q5ZJK0; -.
DR   Proteomes; UP000000539; Chromosome 8.
DR   Bgee; ENSGALG00000004273; Expressed in spermatid and 13 other tissues.
DR   ExpressionAtlas; Q5ZJK0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   GO; GO:0032485; P:regulation of Ral protein signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR030708; RalGPS1/2.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF180; PTHR23113:SF180; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..584
FT                   /note="Ras-specific guanine nucleotide-releasing factor
FT                   RalGPS1"
FT                   /id="PRO_0000333194"
FT   DOMAIN          50..288
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT   DOMAIN          458..570
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           326..329
FT                   /note="PXXP"
FT   COMPBIAS        384..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  65153 MW;  B87FB17EB3D6AD89 CRC64;
     MDLMNGQSSS VNIAATASEK SSSSESLSDK GSAELKKSFD AVVFDVLKVT PEEYAGQITL
     MDVPVFKAIQ PEELASCGWN KKEKYSSAPN AVAFTRRFNH VSFWVVREIL HAQTLKIRAE
     VLSHYIKTAK KLYELNNLHA LMAVVSGLQS APIFRLTKTW ALLSRKDKAT FEKLEYVMSK
     EDNYKRLRDY ISSLKMTPCI PYLGIYLSDL TYIDSAYPST GSILESEQRT NLMNNILRII
     SDLQQSCEYD IPLLPHVQKY LNSVQYIEEL QKFVEDDNYK LSLKIEPGTS TPHSAASRED
     LVASEVGASP QSGRKNAAAE GALLPPTPPS PRNLIPHGHR KCHSLGYNFI HKMNTAEFKS
     ATFPNAGPRH LLDDSVMEPH VPSRGQAESS TLSSGISIGS SDGSELSEET SWPAFERNRL
     YHSLGPGTRV SRNGYRGHMK ASSSLESEDL AVHLYPGAVT IQGVLRRKTL LKEGKKPTVA
     SWTKYWVALC GTQLFYYAAK SLKATERKHF KSTPSKNVSV VGWMVMMADD PEHPDLFLLT
     DSEKGNSYKF QAGNRMNAML WFKHLSAACQ SNRQQVPANL MTFE