ID   RGS10_CAEEL             Reviewed;         270 AA.
AC   O45523;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Regulator of G-protein signaling rgs-10;
GN   Name=rgs-10; ORFNames=F45B8.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=15687288; DOI=10.1101/gr.3194805;
RA   Fernandez A.G., Gunsalus K.C., Huang J., Chuang L.S., Ying N., Liang H.L.,
RA   Tang C., Schetter A.J., Zegar C., Rual J.F., Hill D.E., Reinke V.,
RA   Vidal M., Piano F.;
RT   "New genes with roles in the C. elegans embryo revealed using RNAi of
RT   ovary-enriched ORFeome clones.";
RL   Genome Res. 15:250-259(2005).
CC   -!- FUNCTION: Shown to have a role in viability and embryogenesis.
CC       {ECO:0000269|PubMed:15687288}.
CC   -!- DISRUPTION PHENOTYPE: Sterility and embryonic lethality.
CC       {ECO:0000269|PubMed:15687288}.
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DR   EMBL; Z83227; CAB05727.1; -; Genomic_DNA.
DR   PIR; T22213; T22213.
DR   RefSeq; NP_510482.1; NM_078081.1.
DR   AlphaFoldDB; O45523; -.
DR   SMR; O45523; -.
DR   STRING; 6239.F45B8.2; -.
DR   PaxDb; O45523; -.
DR   PRIDE; O45523; -.
DR   EnsemblMetazoa; F45B8.2.1; F45B8.2.1; WBGene00004353.
DR   GeneID; 185764; -.
DR   KEGG; cel:CELE_F45B8.2; -.
DR   UCSC; F45B8.2; c. elegans.
DR   CTD; 185764; -.
DR   WormBase; F45B8.2; CE10430; WBGene00004353; rgs-10.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00970000196865; -.
DR   HOGENOM; CLU_1031475_0_0_1; -.
DR   InParanoid; O45523; -.
DR   OMA; RIRECNM; -.
DR   OrthoDB; 1481971at2759; -.
DR   PhylomeDB; O45523; -.
DR   Reactome; R-CEL-416476; G alpha (q) signalling events.
DR   Reactome; R-CEL-418594; G alpha (i) signalling events.
DR   PRO; PR:O45523; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00004353; Expressed in embryo and 2 other tissues.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0000003; P:reproduction; IMP:UniProtKB.
DR   Gene3D; 1.10.167.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   Developmental protein; Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..270
FT                   /note="Regulator of G-protein signaling rgs-10"
FT                   /id="PRO_0000223575"
FT   DOMAIN          135..252
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   270 AA;  31286 MW;  9C36042F7A94F5A9 CRC64;
     MSLAVFSPCD VASKLLSEVV GEKYPKVDDD DSIVEPVTSL CLPQLSYEDF HHFSVIPLWN
     KTFPCRLATE WNPKNKKDAP PKKKNALVIL ERVASRSNQN AVSRVINILR SKVHLMFSSS
     NELPSSEDVE RWKKSPETLA ASEYGCNLFI QFLKEQTSEN EVDFWLDCQK FRSSKMSSRQ
     NEARRIFDEY FAMGSPKKIY IERYLWCVVQ AYLVNDPGWR HTFDVAQAYV GLKLAKKSHK
     KFLEDPLYLD LVELVTSGVN YNKFWHDKLE