ID   RGS11_RAT               Reviewed;          66 AA.
AC   P49807;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Regulator of G-protein signaling 11;
DE            Short=RGS11;
DE   Flags: Fragment;
GN   Name=Rgs11;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8548815; DOI=10.1016/s0092-8674(00)80998-8;
RA   Koelle M.R., Horvitz H.R.;
RT   "EGL-10 regulates G protein signaling in the C. elegans nervous system and
RT   shares a conserved domain with many mammalian proteins.";
RL   Cell 84:115-125(1996).
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into their
CC       inactive GDP-bound form.
CC   -!- SUBUNIT: Heterodimer with Gbeta5. Interacts with RGS7BP, leading to
CC       regulate the subcellular location of the heterodimer formed with Gbeta5
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; U32438; AAC52375.1; -; mRNA.
DR   AlphaFoldDB; P49807; -.
DR   SMR; P49807; -.
DR   STRING; 10116.ENSRNOP00000027763; -.
DR   PhosphoSitePlus; P49807; -.
DR   PaxDb; P49807; -.
DR   UCSC; RGD:3563; rat.
DR   RGD; 3563; Rgs11.
DR   eggNOG; KOG3589; Eukaryota.
DR   InParanoid; P49807; -.
DR   PhylomeDB; P49807; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0044292; C:dendrite terminus; ISO:RGD.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0031681; F:G-protein beta-subunit binding; ISO:RGD.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.167.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SUPFAM; SSF48097; SSF48097; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal transduction inhibitor.
FT   CHAIN           <1..>66
FT                   /note="Regulator of G-protein signaling 11"
FT                   /id="PRO_0000204212"
FT   DOMAIN          <1..>66
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT   NON_TER         1
FT   NON_TER         66
SQ   SEQUENCE   66 AA;  7605 MW;  5E95CA702B03F287 CRC64;
     EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT MEWTLEGLRQ PHRYVLDAAQ
     LHIYML