ID   RGS13_MOUSE             Reviewed;         158 AA.
AC   Q8K443;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Regulator of G-protein signaling 13;
DE            Short=RGS13;
GN   Name=Rgs13;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=12193720; DOI=10.4049/jimmunol.169.5.2507;
RA   Shi G.X., Harrison K., Wilson G.L., Moratz C., Kehrl J.H.;
RT   "RGS13 regulates germinal center B lymphocytes responsiveness to CXC
RT   chemokine ligand (CXCL)12 and CXCL13.";
RL   J. Immunol. 169:2507-2515(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into their
CC       inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha.
CC   -!- INTERACTION:
CC       Q8K443; Q9CZW5: Tomm70; NbExp=12; IntAct=EBI-645999, EBI-642469;
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DR   EMBL; AF498319; AAM74139.1; -; mRNA.
DR   EMBL; AK043268; BAC31511.1; -; mRNA.
DR   EMBL; BC049624; AAH49624.1; -; mRNA.
DR   CCDS; CCDS15348.1; -.
DR   RefSeq; NP_694811.1; NM_153171.4.
DR   RefSeq; XP_006529676.1; XM_006529613.2.
DR   AlphaFoldDB; Q8K443; -.
DR   SMR; Q8K443; -.
DR   BioGRID; 232932; 2.
DR   IntAct; Q8K443; 1.
DR   STRING; 10090.ENSMUSP00000058813; -.
DR   iPTMnet; Q8K443; -.
DR   PhosphoSitePlus; Q8K443; -.
DR   PaxDb; Q8K443; -.
DR   PRIDE; Q8K443; -.
DR   ProteomicsDB; 255015; -.
DR   Antibodypedia; 20618; 243 antibodies from 32 providers.
DR   DNASU; 246709; -.
DR   Ensembl; ENSMUST00000052375; ENSMUSP00000058813; ENSMUSG00000051079.
DR   Ensembl; ENSMUST00000111941; ENSMUSP00000107572; ENSMUSG00000051079.
DR   GeneID; 246709; -.
DR   KEGG; mmu:246709; -.
DR   UCSC; uc007cxh.1; mouse.
DR   CTD; 6003; -.
DR   MGI; MGI:2180585; Rgs13.
DR   VEuPathDB; HostDB:ENSMUSG00000051079; -.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000158520; -.
DR   HOGENOM; CLU_059863_1_5_1; -.
DR   InParanoid; Q8K443; -.
DR   OMA; LEFWVVC; -.
DR   OrthoDB; 1416350at2759; -.
DR   PhylomeDB; Q8K443; -.
DR   TreeFam; TF315837; -.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   BioGRID-ORCS; 246709; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Rgs13; mouse.
DR   PRO; PR:Q8K443; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q8K443; protein.
DR   Bgee; ENSMUSG00000051079; Expressed in cumulus cell and 40 other tissues.
DR   Genevisible; Q8K443; MM.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IPI:MGI.
DR   GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IDA:MGI.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 2.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR034954; RGS13.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF32; PTHR10845:SF32; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..158
FT                   /note="Regulator of G-protein signaling 13"
FT                   /id="PRO_0000204216"
FT   DOMAIN          34..150
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   158 AA;  18729 MW;  AC5DD876F4020C1A CRC64;
     MSRHICWICK LCRDESKRLP SNLTLDEVLK WAQSLESLMA TKYGPIVYTA YLKLEHSDEN
     IKFWMACETY KKIASRRGRI SRAKKLYNIY IQPQSPREIN IDSTTREAII KSIREPTQTC
     FEEAQKIVYM HMEMDSYPRF LKSEMYQQLL KTVQSQSS