RGS18_MOUSE
ID RGS18_MOUSE Reviewed; 235 AA.
AC Q99PG4;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Regulator of G-protein signaling 18;
DE Short=RGS18;
GN Name=Rgs18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BA;
RX PubMed=11042171; DOI=10.1074/jbc.m005947200;
RA Park I.K., Klug C.A., Li K., Jerabek L., Li L., Nanamori M., Neubig R.R.,
RA Hood L., Weissman I.L., Clarke M.F.;
RT "Molecular cloning and characterization of a novel regulator of G-protein
RT signaling from mouse hematopoietic stem cells.";
RL J. Biol. Chem. 276:915-923(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BDF1;
RX PubMed=11342430; DOI=10.1182/blood.v97.10.3051;
RA Nagata Y., Oda M., Nakata H., Shozaki Y., Kozasa T., Todokoro K.;
RT "A novel regulator of G-protein signaling bearing GAP activity for Galphai
RT and Galphaq in megakaryocytes.";
RL Blood 97:3051-3060(2001).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216 AND SER-218, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC activity of G protein alpha subunits thereby driving them into their
CC inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i)
CC alpha-3 and G(q) alpha.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Expressed in bone marrow, spleen, fetal liver and
CC lung. At very low levels expressed in heart.
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DR EMBL; AF302685; AAG53657.1; -; mRNA.
DR EMBL; AB042807; BAB60723.1; -; mRNA.
DR CCDS; CCDS15350.1; -.
DR RefSeq; NP_075019.1; NM_022881.4.
DR AlphaFoldDB; Q99PG4; -.
DR SMR; Q99PG4; -.
DR BioGRID; 211040; 3.
DR STRING; 10090.ENSMUSP00000027603; -.
DR iPTMnet; Q99PG4; -.
DR PhosphoSitePlus; Q99PG4; -.
DR jPOST; Q99PG4; -.
DR MaxQB; Q99PG4; -.
DR PaxDb; Q99PG4; -.
DR PRIDE; Q99PG4; -.
DR ProteomicsDB; 253122; -.
DR Antibodypedia; 20616; 193 antibodies from 30 providers.
DR DNASU; 64214; -.
DR Ensembl; ENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357.
DR GeneID; 64214; -.
DR KEGG; mmu:64214; -.
DR UCSC; uc007cxl.1; mouse.
DR CTD; 64407; -.
DR MGI; MGI:1927498; Rgs18.
DR VEuPathDB; HostDB:ENSMUSG00000026357; -.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000161034; -.
DR HOGENOM; CLU_059863_3_2_1; -.
DR InParanoid; Q99PG4; -.
DR OMA; YNEFQDV; -.
DR OrthoDB; 1193829at2759; -.
DR PhylomeDB; Q99PG4; -.
DR TreeFam; TF315837; -.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 64214; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Rgs18; mouse.
DR PRO; PR:Q99PG4; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q99PG4; protein.
DR Bgee; ENSMUSG00000026357; Expressed in granulocyte and 90 other tissues.
DR ExpressionAtlas; Q99PG4; baseline and differential.
DR Genevisible; Q99PG4; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005096; F:GTPase activator activity; IDA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IPI:MGI.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IDA:MGI.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR034950; RGS18.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR10845:SF155; PTHR10845:SF155; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR PROSITE; PS50132; RGS; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome;
KW Signal transduction inhibitor.
FT CHAIN 1..235
FT /note="Regulator of G-protein signaling 18"
FT /id="PRO_0000204228"
FT DOMAIN 86..202
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NS28"
FT MOD_RES 216
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 218
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 235 AA; 27610 MW; 6433435AC1CBCFD8 CRC64;
MDMSLVFFSQ LNMCESKEKT FFKLMHGSGK EETSIEAKIR AKEKRNRLSL LLQRPDFHGE
TQASRSALLA KETRVSPEEA VKWAESFDKL LSHRDGVDAF TRFLKTEFSE ENIEFWVACE
DFKKCKEPQQ IILKAKAIYE KFIQNDAPKE VNIDFHTKEV IAKSIAQPTL HSFDTAQSRV
YQLMEHDSYK RFLKSETYLH LIEGRPQRPT NLRRRSRSFT YNDFQDVKSD VAIWL
