RGS1_CAEEL
ID RGS1_CAEEL Reviewed; 201 AA.
AC P34295; Q9NHP9;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Regulator of G-protein signaling rgs-1;
GN Name=rgs-1; ORFNames=C05B5.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10950865;
RA Dong M.-Q., Chase D., Patikoglou G.A., Koelle M.R.;
RT "Multiple RGS proteins alter neural G protein signaling to allow C. elegans
RT to rapidly change behavior when fed.";
RL Genes Dev. 14:2003-2014(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Inhibits G protein signaling in nervous system, interacting
CC preferentially with the G(O) subfamily member goa-1. In vitro, protein
CC acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust
CC signaling when worms are fed to allow rapid induction of egg-laying
CC behavior. {ECO:0000269|PubMed:10950865}.
CC -!- TISSUE SPECIFICITY: Expressed in most or all neurons.
CC {ECO:0000269|PubMed:10950865}.
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DR EMBL; AF220159; AAF33236.1; -; mRNA.
DR EMBL; Z32679; CAA83595.2; -; Genomic_DNA.
DR PIR; G88571; G88571.
DR RefSeq; NP_001255057.1; NM_001268128.1.
DR AlphaFoldDB; P34295; -.
DR SMR; P34295; -.
DR BioGRID; 41609; 1.
DR STRING; 6239.C05B5.7b; -.
DR EPD; P34295; -.
DR PaxDb; P34295; -.
DR EnsemblMetazoa; C05B5.7a.1; C05B5.7a.1; WBGene00004344.
DR EnsemblMetazoa; C05B5.7a.2; C05B5.7a.2; WBGene00004344.
DR UCSC; C05B5.7; c. elegans.
DR WormBase; C05B5.7a; CE27794; WBGene00004344; rgs-1.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00970000196738; -.
DR HOGENOM; CLU_059863_1_2_1; -.
DR InParanoid; P34295; -.
DR PhylomeDB; P34295; -.
DR PRO; PR:P34295; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00004344; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; P34295; baseline and differential.
DR GO; GO:0005096; F:GTPase activator activity; IDA:WormBase.
DR GO; GO:0007635; P:chemosensory behavior; IMP:UniProtKB.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0050913; P:sensory perception of bitter taste; IMP:UniProtKB.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR PROSITE; PS50132; RGS; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Signal transduction inhibitor.
FT CHAIN 1..201
FT /note="Regulator of G-protein signaling rgs-1"
FT /id="PRO_0000204237"
FT DOMAIN 37..156
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT REGION 168..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 201 AA; 23287 MW; B15A1B185A01E1B4 CRC64;
MGYMGCWCSN LGRKYSGTVS PQRSVQPEAL SYEMVYSWQQ SFDTLMSFKS GQKCFAEFLK
SEYSDENILF WQACEELKRE KNSEKMEEKA RIIYEDFISI LSPKEVSLDS KVREIVNTNM
SRPTQNTFED AQHQIYQLMA RDSYPRFLTS IFYRETLASF GITEMDIGGD EEKEREQRAE
RARLNVPATA AEGSSKDISM V
