RGS1_HORSE
ID RGS1_HORSE Reviewed; 196 AA.
AC Q6RG78;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Regulator of G-protein signaling 1;
DE Short=RGS1;
GN Name=RGS1;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Takafuji V.A., Woody S.L., Crisman M.V., Howard R.D.;
RT "Equus caballus regulator of G-protein signaling 1 (RGS1) mRNA.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates G protein-coupled receptor signaling cascades,
CC including signaling downstream of the N-formylpeptide chemoattractant
CC receptors and leukotriene receptors. Inhibits B cell chemotaxis toward
CC CXCL12 (By similarity). Inhibits signal transduction by increasing the
CC GTPase activity of G protein alpha subunits, thereby driving them into
CC their inactive GDP-bound form (By similarity).
CC {ECO:0000250|UniProtKB:Q08116, ECO:0000250|UniProtKB:Q9JL25}.
CC -!- SUBUNIT: Interacts with GNAI1 and GNAQ. {ECO:0000250|UniProtKB:Q08116}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q08116};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q08116}; Cytoplasmic
CC side {ECO:0000250|UniProtKB:Q08116}. Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q08116}.
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DR EMBL; AY499344; AAR91750.1; -; mRNA.
DR RefSeq; NP_001075408.1; NM_001081939.1.
DR AlphaFoldDB; Q6RG78; -.
DR SMR; Q6RG78; -.
DR STRING; 9796.ENSECAP00000003936; -.
DR PaxDb; Q6RG78; -.
DR GeneID; 100034151; -.
DR KEGG; ecb:100034151; -.
DR CTD; 5996; -.
DR HOGENOM; CLU_059863_3_3_1; -.
DR InParanoid; Q6RG78; -.
DR OMA; NGKEDCK; -.
DR OrthoDB; 1240467at2759; -.
DR TreeFam; TF315837; -.
DR Proteomes; UP000002281; Unplaced.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0061737; P:leukotriene signaling pathway; ISS:UniProtKB.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 1.10.196.10; -; 2.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR030409; RGS1.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR10845:SF34; PTHR10845:SF34; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR PROSITE; PS50132; RGS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; GTPase activation; Membrane; Reference proteome;
KW Signal transduction inhibitor.
FT CHAIN 1..196
FT /note="Regulator of G-protein signaling 1"
FT /id="PRO_0000204174"
FT DOMAIN 72..187
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 196 AA; 22544 MW; BA815D2F66856D16 CRC64;
MPGMFFSANP KDLKGTDQSL LDDKTQKRRP KTFGMDVKAY LRSMIPHLES GMKSSKSKDI
LSADEVMQWS QSLEKLLANQ TGQDVFGNFL KSEFSEENIE FWLACEDYKK TESDLLRCKA
EKIYKAFVHS DAAKQINIDF HTRESTAKKI KAPTLTCFDE AQKVIYTLME KDSYPRFLKS
NIYLNLLNDL QANSLK
