ID   RGS1_SCHPO              Reviewed;         481 AA.
AC   Q09777;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 136.
DE   RecName: Full=Regulator of G-protein signaling 1;
GN   Name=rgs1; ORFNames=SPAC22F3.12c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DOMAIN FUNGAL-DR.
RX   PubMed=11554925; DOI=10.1046/j.1365-2443.2001.00465.x;
RA   Pereira P.S., Jones N.C.;
RT   "The RGS domain-containing fission yeast protein, Rgs1p, regulates
RT   pheromone signalling and is required for mating.";
RL   Genes Cells 6:789-802(2001).
CC   -!- FUNCTION: Negatively regulates pheromone signaling during mating. Acts
CC       in a negative feedback loop that is essential for the mating process.
CC       This loop acts to down-regulate cellular sensitivity to pheromone.
CC       Activated by ste11. {ECO:0000269|PubMed:11554925}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11554925}. Cytoplasm
CC       {ECO:0000269|PubMed:11554925}.
CC   -!- INDUCTION: By nitrogen starvation and pheromone.
CC       {ECO:0000269|PubMed:11554925}.
CC   -!- DOMAIN: The fungal-differentiation regulator (Fungal-DR) domain is only
CC       found in fungal regulator of G-protein signaling (RGS) proteins that
CC       regulate differentiation pathways. It is required for function.
CC       {ECO:0000269|PubMed:11554925}.
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DR   EMBL; CU329670; CAA91077.1; -; Genomic_DNA.
DR   PIR; T38179; S62427.
DR   RefSeq; NP_593029.1; NM_001018428.2.
DR   AlphaFoldDB; Q09777; -.
DR   BioGRID; 278258; 5.
DR   STRING; 4896.SPAC22F3.12c.1; -.
DR   iPTMnet; Q09777; -.
DR   PaxDb; Q09777; -.
DR   EnsemblFungi; SPAC22F3.12c.1; SPAC22F3.12c.1:pep; SPAC22F3.12c.
DR   GeneID; 2541764; -.
DR   KEGG; spo:SPAC22F3.12c; -.
DR   PomBase; SPAC22F3.12c; rgs1.
DR   VEuPathDB; FungiDB:SPAC22F3.12c; -.
DR   eggNOG; KOG3589; Eukaryota.
DR   HOGENOM; CLU_567611_0_0_1; -.
DR   InParanoid; Q09777; -.
DR   OMA; CANNDDR; -.
DR   PhylomeDB; Q09777; -.
DR   PRO; PR:Q09777; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; ISO:PomBase.
DR   GO; GO:0090029; P:negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:PomBase.
DR   GO; GO:0071507; P:pheromone response MAPK cascade; IMP:PomBase.
DR   Gene3D; 1.10.167.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00049; DEP; 2.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Pheromone response; Reference proteome;
KW   Stress response.
FT   CHAIN           1..481
FT                   /note="Regulator of G-protein signaling 1"
FT                   /id="PRO_0000204242"
FT   DOMAIN          232..312
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   DOMAIN          344..474
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          33..227
FT                   /note="Fungal-DR"
FT   COMPBIAS        11..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   481 AA;  54362 MW;  FE80CB5E78E88A9D CRC64;
     MPALHNPSSP PPSYEAVTSY RNGNSIDSGD KRQQCSRLMK ITSNGRPYSK DFLELFSTMV
     ISTNFSRNRY RFSYVENSCT LLQLLSTLEN LQLSQVNRIK SRCGSKVLKS TTKFTIPKTA
     AKCLCNTFLN ARLLQIVNNP SARKFSNEKC LLQLTRKGYS VVSEFLQHNG HNSQAELYAS
     KWNHSAPVIV SISRFSSTDQ ILKDSSFCEM LLVRMLGSVH EIGKSKNPLL VPVYSVSSPS
     PKDSLSKVTK YQMFGIDIAE WLMCNTMLLD WSEMETVASD LLIHSYIAYE NNSETPLKFS
     YAKGVSYFLT GKGIATLGWT KNVSNNKLIN KINEVEKGST NKEILETILR KPNLQTYFFE
     FLKKNFCDEN QRFYSEVCEF NDYFSHANET NDHEAIRESF AHACGIYNCF LSSNAPNAVN
     LPSDLYEKIT NHMALAMEVE PLNEWLQLIH ILLLEAQTAV LDLMAGDSLL KFLELNGGLG
     I