ID   RGS1_XENLA              Reviewed;         201 AA.
AC   A1A643;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Regulator of G-protein signaling 1;
DE            Short=RGS1;
GN   Name=rgs1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates G protein-coupled receptor signaling cascades,
CC       including signaling downstream of the N-formylpeptide chemoattractant
CC       receptors and leukotriene receptors. Inhibits B cell chemotaxis (By
CC       similarity). Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits, thereby driving them into their
CC       inactive GDP-bound form (By similarity). {ECO:0000250|UniProtKB:Q08116,
CC       ECO:0000250|UniProtKB:Q9JL25}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q08116};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:Q08116}; Cytoplasmic
CC       side {ECO:0000250|UniProtKB:Q08116}. Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q08116}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI28960.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC128959; AAI28960.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; A1A643; -.
DR   SMR; A1A643; -.
DR   OMA; IFILMER; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0061737; P:leukotriene signaling pathway; ISS:UniProtKB.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 2.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR030409; RGS1.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF34; PTHR10845:SF34; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; GTPase activation; Membrane; Reference proteome;
KW   Signal transduction inhibitor.
FT   CHAIN           1..201
FT                   /note="Regulator of G-protein signaling 1"
FT                   /id="PRO_0000364205"
FT   DOMAIN          75..191
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   201 AA;  23299 MW;  DA9FC4B9D21CD854 CRC64;
     MPGIFFSHPN ALKEVTNKPD EVMAQKKKNF AVPWKNYLKS MLPHLETIKS SSSSSSSDTE
     KNKLTPNEII QWTMSLEKLL VSEEGQAVFR AFLKSEFSEE NIEFWLACED YKATNDSEEL
     RCKANVIYQE FIQPNANKQI NIDFSTRNSV TKDLLEPTKA TFNGAQKMIF ILMERDSYPR
     FLKSEIFFRL AERHHGNNMR G