ID   RGS1_XENTR              Reviewed;         201 AA.
AC   Q5M8L6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Regulator of G-protein signaling 1;
DE            Short=RGS1;
GN   Name=rgs1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates G protein-coupled receptor signaling cascades,
CC       including signaling downstream of the N-formylpeptide chemoattractant
CC       receptors and leukotriene receptors. Inhibits B cell chemotaxis (By
CC       similarity). Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits, thereby driving them into their
CC       inactive GDP-bound form (By similarity). {ECO:0000250|UniProtKB:Q08116,
CC       ECO:0000250|UniProtKB:Q9JL25}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q08116};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:Q08116}; Cytoplasmic
CC       side {ECO:0000250|UniProtKB:Q08116}. Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q08116}.
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DR   EMBL; BC087970; AAH87970.1; -; mRNA.
DR   RefSeq; XP_002939124.2; XM_002939078.2.
DR   AlphaFoldDB; Q5M8L6; -.
DR   SMR; Q5M8L6; -.
DR   STRING; 8364.ENSXETP00000012507; -.
DR   PaxDb; Q5M8L6; -.
DR   GeneID; 496714; -.
DR   KEGG; xtr:496714; -.
DR   CTD; 5996; -.
DR   Xenbase; XB-GENE-968765; rgs1.
DR   eggNOG; KOG3589; Eukaryota.
DR   HOGENOM; CLU_059863_3_3_1; -.
DR   InParanoid; Q5M8L6; -.
DR   OrthoDB; 1240467at2759; -.
DR   Reactome; R-XTR-416476; G alpha (q) signalling events.
DR   Reactome; R-XTR-418594; G alpha (i) signalling events.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q5M8L6; baseline.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 2.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR030409; RGS1.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF34; PTHR10845:SF34; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; GTPase activation; Membrane; Reference proteome.
FT   CHAIN           1..201
FT                   /note="Regulator of G-protein signaling 1"
FT                   /id="PRO_0000364206"
FT   DOMAIN          75..191
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   201 AA;  23331 MW;  8657FA62CB25121F CRC64;
     MPGIFFSHAN ALKEVDNKPD EVMAQKKKNF AVDLKNYLKS MLPHLETMKS SSSTSSSDSE
     KNKLTPDEII QWTMSLEKLL ISEDGQSVFR EFLKSEFSEE NIEFWLACED YKATNDSEEL
     RCKANVIYQE FIQPNANKQI NIDFSTRNSV TKDLLEPTIT TFNDAQKMIF ILMERDSYPR
     FLKSEIFLRL AERHHGNNVR G