ID   RGS21_HUMAN             Reviewed;         152 AA.
AC   Q2M5E4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Regulator of G-protein signaling 21;
DE            Short=RGS21;
GN   Name=RGS21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Fetal brain;
RX   PubMed=16302027;
RA   Li X., Chen L., Ji C., Liu B., Gu J., Xu J., Zou X., Gu S., Mao Y.;
RT   "Isolation and expression pattern of RGS21 gene, a novel RGS member.";
RL   Acta Biochim. Pol. 52:943-946(2005).
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into their
CC       inactive GDP-bound form. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC       {ECO:0000269|PubMed:16302027}.
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DR   EMBL; AY643711; AAT64913.1; -; mRNA.
DR   CCDS; CCDS41448.1; -.
DR   RefSeq; NP_001034241.1; NM_001039152.3.
DR   AlphaFoldDB; Q2M5E4; -.
DR   SMR; Q2M5E4; -.
DR   STRING; 9606.ENSP00000428343; -.
DR   iPTMnet; Q2M5E4; -.
DR   PhosphoSitePlus; Q2M5E4; -.
DR   BioMuta; RGS21; -.
DR   DMDM; 121941516; -.
DR   MassIVE; Q2M5E4; -.
DR   PaxDb; Q2M5E4; -.
DR   PeptideAtlas; Q2M5E4; -.
DR   PRIDE; Q2M5E4; -.
DR   Antibodypedia; 58786; 72 antibodies from 24 providers.
DR   DNASU; 431704; -.
DR   Ensembl; ENST00000417209.2; ENSP00000428343.1; ENSG00000253148.1.
DR   GeneID; 431704; -.
DR   KEGG; hsa:431704; -.
DR   MANE-Select; ENST00000417209.2; ENSP00000428343.1; NM_001039152.3; NP_001034241.1.
DR   UCSC; uc001gsh.4; human.
DR   CTD; 431704; -.
DR   DisGeNET; 431704; -.
DR   GeneCards; RGS21; -.
DR   HGNC; HGNC:26839; RGS21.
DR   HPA; ENSG00000253148; Not detected.
DR   MIM; 612407; gene.
DR   neXtProt; NX_Q2M5E4; -.
DR   OpenTargets; ENSG00000253148; -.
DR   PharmGKB; PA134875582; -.
DR   VEuPathDB; HostDB:ENSG00000253148; -.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000161004; -.
DR   HOGENOM; CLU_059863_1_5_1; -.
DR   InParanoid; Q2M5E4; -.
DR   OMA; VKGRCCF; -.
DR   OrthoDB; 1246872at2759; -.
DR   PhylomeDB; Q2M5E4; -.
DR   TreeFam; TF315837; -.
DR   PathwayCommons; Q2M5E4; -.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   SignaLink; Q2M5E4; -.
DR   BioGRID-ORCS; 431704; 11 hits in 1055 CRISPR screens.
DR   GenomeRNAi; 431704; -.
DR   Pharos; Q2M5E4; Tdark.
DR   PRO; PR:Q2M5E4; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q2M5E4; protein.
DR   Bgee; ENSG00000253148; Expressed in ganglionic eminence.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0003924; F:GTPase activity; TAS:Reactome.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR   GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR   GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..152
FT                   /note="Regulator of G-protein signaling 21"
FT                   /id="PRO_0000271375"
FT   DOMAIN          21..137
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   152 AA;  17671 MW;  D9EF097E89CA9731 CRC64;
     MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF WLACEDFKKT
     KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI AEPTLKCFDE AQKLIYCLMA
     KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP FL