ID   RGS2_BOVIN              Reviewed;         211 AA.
AC   Q0P5H5;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Regulator of G-protein signaling 2;
DE            Short=RGS2;
GN   Name=RGS2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates G protein-coupled receptor signaling cascades.
CC       Inhibits signal transduction by increasing the GTPase activity of G
CC       protein alpha subunits, thereby driving them into their inactive GDP-
CC       bound form (By similarity). It is involved in the negative regulation
CC       of the angiotensin-activated signaling pathway (By similarity). Plays a
CC       role in the regulation of blood pressure in response to signaling via G
CC       protein-coupled receptors and GNAQ. Plays a role in regulating the
CC       constriction and relaxation of vascular smooth muscle (By similarity).
CC       Binds EIF2B5 and blocks its activity, thereby inhibiting the
CC       translation of mRNA into protein (By similarity).
CC       {ECO:0000250|UniProtKB:O08849, ECO:0000250|UniProtKB:P41220}.
CC   -!- SUBUNIT: Interacts with GNAQ. Does not interact with GNAI1 and GNAI3.
CC       Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).
CC       {ECO:0000250|UniProtKB:P41220}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P41220}.
CC       Cytoplasm {ECO:0000250|UniProtKB:P41220}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P41220}.
CC   -!- PTM: Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads
CC       to activation of RGS2 activity. {ECO:0000250|UniProtKB:P41220}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC120026; AAI20027.1; -; mRNA.
DR   RefSeq; NP_001069064.1; NM_001075596.1.
DR   AlphaFoldDB; Q0P5H5; -.
DR   SMR; Q0P5H5; -.
DR   PaxDb; Q0P5H5; -.
DR   PRIDE; Q0P5H5; -.
DR   Ensembl; ENSBTAT00000027478; ENSBTAP00000067806; ENSBTAG00000020620.
DR   GeneID; 513055; -.
DR   KEGG; bta:513055; -.
DR   CTD; 5997; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020620; -.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000157937; -.
DR   InParanoid; Q0P5H5; -.
DR   OMA; THTEMAS; -.
DR   OrthoDB; 1246872at2759; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000020620; Expressed in oocyte and 65 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045744; P:negative regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR034947; RGS2.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF43; PTHR10845:SF43; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell membrane; Cytoplasm; GTPase activation; Membrane; Nucleus;
KW   Phosphoprotein; Reference proteome; Signal transduction inhibitor;
KW   Translation regulation.
FT   CHAIN           1..211
FT                   /note="Regulator of G-protein signaling 2"
FT                   /id="PRO_0000271374"
FT   DOMAIN          83..199
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT   REGION          14..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          32..66
FT                   /note="Necessary for membrane association"
FT                   /evidence="ECO:0000250|UniProtKB:P41220"
FT   REGION          49..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..116
FT                   /note="Necessary to inhibit protein synthesis"
FT                   /evidence="ECO:0000250|UniProtKB:P41220"
SQ   SEQUENCE   211 AA;  24210 MW;  D25DC20E24FE9FD6 CRC64;
     MQSALFLAVQ HECGPMDKGA GTGPKNEEKR EKMKRTLLKD WKSRLSYFLQ NSSSPGKPKT
     GKKSKQQTFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK
     KTKSPQKLSS KAKKIYTDFI EKEAPKEINI DFQTKSLIAQ NIQEATSGCF TTAQKRVYSL
     MENNSYPRFL ESEFYQDLCK KPQITTEPHA T