RGS4_BOVIN
ID RGS4_BOVIN Reviewed; 205 AA.
AC Q29RM9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Regulator of G-protein signaling 4;
DE Short=RGS4;
GN Name=RGS4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC activity of G protein alpha subunits thereby driving them into their
CC inactive GDP-bound form. Activity on G(z)-alpha is inhibited by
CC phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-
CC alpha-1 is inhibited by palmitoylation of the G-protein (By
CC similarity). {ECO:0000250}.
CC -!- PTM: Palmitoylated on Cys-2 and/or Cys-12. {ECO:0000250}.
CC -!- PTM: Phosphorylated by cyclic GMP-dependent protein kinase.
CC {ECO:0000250}.
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DR EMBL; BC114106; AAI14107.1; -; mRNA.
DR RefSeq; NP_001040065.1; NM_001046600.2.
DR AlphaFoldDB; Q29RM9; -.
DR SMR; Q29RM9; -.
DR STRING; 9913.ENSBTAP00000055609; -.
DR PaxDb; Q29RM9; -.
DR PRIDE; Q29RM9; -.
DR Ensembl; ENSBTAT00000065520; ENSBTAP00000055609; ENSBTAG00000046277.
DR GeneID; 617437; -.
DR KEGG; bta:617437; -.
DR CTD; 5999; -.
DR VEuPathDB; HostDB:ENSBTAG00000046277; -.
DR VGNC; VGNC:54394; RGS4.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000159036; -.
DR HOGENOM; CLU_059863_3_0_1; -.
DR InParanoid; Q29RM9; -.
DR OMA; LINHECG; -.
DR OrthoDB; 1435659at2759; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000046277; Expressed in occipital lobe and 80 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd08714; RGS_RGS4; 1.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR034952; RGS4.
DR InterPro; IPR034953; RGS_RGS4.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR10845:SF184; PTHR10845:SF184; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR PROSITE; PS50132; RGS; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Palmitate; Phosphoprotein; Reference proteome;
KW Signal transduction inhibitor.
FT CHAIN 1..205
FT /note="Regulator of G-protein signaling 4"
FT /id="PRO_0000244458"
FT DOMAIN 62..178
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT LIPID 2
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 12
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 95
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 205 AA; 23328 MW; 47F56C83C9FE84DC CRC64;
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHS KKDKVVICQR VSHEEVKKWA
ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS
VQATKEVNLD SCTREETSRN MLEPTITCFD EAQRKIFNLM EKDSYRRFLK SRFYLDLVNL
SSCGSEKQKG AKSSTDCASL VPQCA
