ID   RGS4_CHICK              Reviewed;         208 AA.
AC   Q7SZC6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Regulator of G-protein signaling 4;
DE            Short=RGS4;
GN   Name=RGS4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Hindbrain;
RX   PubMed=14627646; DOI=10.1523/jneurosci.23-33-10613.2003;
RA   Grillet N., Dubreuil V., Dufour H.D., Brunet J.-F.;
RT   "Dynamic expression of RGS4 in the developing nervous system and regulation
RT   by the neural type-specific transcription factor Phox2b.";
RL   J. Neurosci. 23:10613-10621(2003).
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into their
CC       inactive GDP-bound form. Activity on G(z)-alpha is inhibited by
CC       phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-
CC       alpha-1 is inhibited by palmitoylation of the G-protein (By
CC       similarity). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing nervous system.
CC       {ECO:0000269|PubMed:14627646}.
CC   -!- PTM: Palmitoylated on Cys-2 and/or Cys-12. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by cyclic GMP-dependent protein kinase.
CC       {ECO:0000250}.
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DR   EMBL; AY297457; AAP57222.1; -; mRNA.
DR   RefSeq; NP_989716.1; NM_204385.1.
DR   AlphaFoldDB; Q7SZC6; -.
DR   SMR; Q7SZC6; -.
DR   STRING; 9031.ENSGALP00000004041; -.
DR   PaxDb; Q7SZC6; -.
DR   PRIDE; Q7SZC6; -.
DR   GeneID; 378901; -.
DR   KEGG; gga:378901; -.
DR   CTD; 5999; -.
DR   VEuPathDB; HostDB:geneid_378901; -.
DR   eggNOG; KOG3589; Eukaryota.
DR   InParanoid; Q7SZC6; -.
DR   OrthoDB; 1435659at2759; -.
DR   PhylomeDB; Q7SZC6; -.
DR   PRO; PR:Q7SZC6; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd08714; RGS_RGS4; 1.
DR   Gene3D; 1.10.167.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR034952; RGS4.
DR   InterPro; IPR034953; RGS_RGS4.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF184; PTHR10845:SF184; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Palmitate; Phosphoprotein; Reference proteome;
KW   Signal transduction inhibitor.
FT   CHAIN           1..208
FT                   /note="Regulator of G-protein signaling 4"
FT                   /id="PRO_0000280761"
FT   DOMAIN          62..178
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT   LIPID           2
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           12
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           95
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   208 AA;  23523 MW;  838B31750FF0EA68 CRC64;
     MCKGLAALPA TCLKSAKDMK HRLGVLLQKS DSCDYGSSQG KKEKVSSSQR VSQEEVKKWA
     ESLENLIHHD RGLAAFRAFL KSEYSEENIE FWVSCEDYKK TKSPAKLSTK ARKIYDEFIS
     VQATKEVNLD SCTREKTSHN MLEPTLSCFD EAQRKIFTLM EKDSYRRFLK SPYLDLVSPP
     RAGCGPENCK RAHAHALDCN SNIISQCA