ID   RGS4_RABIT              Reviewed;         205 AA.
AC   Q0R4E4;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Regulator of G-protein signaling 4;
DE            Short=RGS4;
GN   Name=RGS4;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Stomach;
RA   Hu W.H., Li F., Huang J.A., Mahavadi S., Murthy K.S.;
RT   "Inflammatory regulation of RGS4 in rabbit gut smooth muscle cells.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into their
CC       inactive GDP-bound form. Activity on G(z)-alpha is inhibited by
CC       phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-
CC       alpha-1 is inhibited by palmitoylation of the G-protein (By
CC       similarity). {ECO:0000250}.
CC   -!- PTM: Palmitoylated on Cys-2 and/or Cys-12. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by cyclic GMP-dependent protein kinase.
CC       {ECO:0000250}.
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DR   EMBL; DQ120011; AAZ94718.1; -; mRNA.
DR   RefSeq; NP_001075683.1; NM_001082214.1.
DR   AlphaFoldDB; Q0R4E4; -.
DR   SMR; Q0R4E4; -.
DR   STRING; 9986.ENSOCUP00000004507; -.
DR   iPTMnet; Q0R4E4; -.
DR   Ensembl; ENSOCUT00000005202; ENSOCUP00000004507; ENSOCUG00000005204.
DR   GeneID; 100009014; -.
DR   KEGG; ocu:100009014; -.
DR   CTD; 5999; -.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000159036; -.
DR   HOGENOM; CLU_059863_3_0_1; -.
DR   InParanoid; Q0R4E4; -.
DR   OMA; LINHECG; -.
DR   OrthoDB; 1435659at2759; -.
DR   TreeFam; TF315837; -.
DR   Proteomes; UP000001811; Chromosome 13.
DR   Bgee; ENSOCUG00000005204; Expressed in frontal cortex and 16 other tissues.
DR   ExpressionAtlas; Q0R4E4; baseline.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd08714; RGS_RGS4; 1.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR034952; RGS4.
DR   InterPro; IPR034953; RGS_RGS4.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF184; PTHR10845:SF184; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Palmitate; Phosphoprotein; Reference proteome;
KW   Signal transduction inhibitor.
FT   CHAIN           1..205
FT                   /note="Regulator of G-protein signaling 4"
FT                   /id="PRO_0000261132"
FT   DOMAIN          62..178
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT   LIPID           2
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           12
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           95
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   205 AA;  23299 MW;  BC4292CB8377626B CRC64;
     MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHS KKDKVVVCQR VSQEEVKKWA
     ESLENLINHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS
     VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLANP
     SNCGSEKQKG AKSSVDCASL LPQCA