ID   RGS5_BOVIN              Reviewed;         181 AA.
AC   Q3T0T8;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Regulator of G-protein signaling 5;
DE            Short=RGS5;
GN   Name=RGS5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into their
CC       inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to
CC       G(s)-alpha (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O15539}.
CC       Membrane {ECO:0000250|UniProtKB:O15539}.
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DR   EMBL; BC102265; AAI02266.1; -; mRNA.
DR   RefSeq; NP_001029879.1; NM_001034707.2.
DR   AlphaFoldDB; Q3T0T8; -.
DR   SMR; Q3T0T8; -.
DR   STRING; 9913.ENSBTAP00000032130; -.
DR   PaxDb; Q3T0T8; -.
DR   Ensembl; ENSBTAT00000032193; ENSBTAP00000032130; ENSBTAG00000016341.
DR   GeneID; 540509; -.
DR   KEGG; bta:540509; -.
DR   CTD; 8490; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016341; -.
DR   VGNC; VGNC:55670; RGS5.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000157380; -.
DR   HOGENOM; CLU_059863_3_0_1; -.
DR   InParanoid; Q3T0T8; -.
DR   OMA; MAQKRIF; -.
DR   OrthoDB; 1416350at2759; -.
DR   TreeFam; TF315837; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000016341; Expressed in trachea and 102 other tissues.
DR   ExpressionAtlas; Q3T0T8; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd08717; RGS_RGS5; 1.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR034955; RGS5.
DR   InterPro; IPR034956; RGS_RGS5.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF42; PTHR10845:SF42; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..181
FT                   /note="Regulator of G-protein signaling 5"
FT                   /id="PRO_0000239867"
FT   DOMAIN          64..180
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   181 AA;  20969 MW;  FC84EE7242BB4B1F CRC64;
     MCKGLAALPH SCLERAKEIK IKLGILLQKP ESAIDLVIPY NEKPEKPAKT QKPSLDEALQ
     WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWMACEDY KKIKSPVKMA ETAKKIYEEF
     IQVEAPKEVN IDHFTKEITV KNLVEPSPSS FDVAQKRIHA LMEKDSLPRF VRSEFYQEFI
     K