RGS5_CAEEL
ID RGS5_CAEEL Reviewed; 492 AA.
AC Q10955;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 4.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Regulator of G-protein signaling rgs-5;
GN Name=rgs-5; ORFNames=B0336.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; FO080138; CCD61518.1; -; Genomic_DNA.
DR RefSeq; NP_498229.3; NM_065828.7.
DR AlphaFoldDB; Q10955; -.
DR SMR; Q10955; -.
DR STRING; 6239.B0336.4a; -.
DR EPD; Q10955; -.
DR PaxDb; Q10955; -.
DR PeptideAtlas; Q10955; -.
DR PRIDE; Q10955; -.
DR EnsemblMetazoa; B0336.4a.1; B0336.4a.1; WBGene00004348.
DR GeneID; 175794; -.
DR KEGG; cel:CELE_B0336.4; -.
DR UCSC; B0336.4b; c. elegans.
DR CTD; 175794; -.
DR WormBase; B0336.4a; CE32098; WBGene00004348; rgs-5.
DR eggNOG; KOG3590; Eukaryota.
DR GeneTree; ENSGT00390000015077; -.
DR InParanoid; Q10955; -.
DR OMA; YFSMQAT; -.
DR OrthoDB; 644347at2759; -.
DR PhylomeDB; Q10955; -.
DR Reactome; R-CEL-983231; Factors involved in megakaryocyte development and platelet production.
DR PRO; PR:Q10955; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00004348; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; Q10955; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR Gene3D; 1.10.167.10; -; 2.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR Pfam; PF00615; RGS; 2.
DR SMART; SM00315; RGS; 2.
DR SUPFAM; SSF48097; SSF48097; 2.
DR PROSITE; PS50132; RGS; 2.
PE 4: Predicted;
KW Reference proteome; Repeat; Signal transduction inhibitor.
FT CHAIN 1..492
FT /note="Regulator of G-protein signaling rgs-5"
FT /id="PRO_0000223701"
FT DOMAIN 81..205
FT /note="RGS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT DOMAIN 214..337
FT /note="RGS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 55924 MW; 1C0C3D5429B0B90A CRC64;
MSSFLGRLRR KKDKEQNGHT ATSSDGAYQN GNAHRDSLVN DHICIPAQRN SLTVAQQSAD
IGSGSDHEGI IVKQKPQLAF SLDRLLIDSS ALSYFIQYLD STDKLNLIKF WMHVEGFKSS
FSEQIQAAQE LSLRDAKSIY DKYIDDGSTS SLALPRKIKQ IVDDKLSASP LQKSCFDEAQ
DFVKSLFEYR YFDEFQNSVY YKKHELEVLS DGCSLADILK VQPLLLSFLE FIKEKEDHDT
IQFLLGCDSF EANLDLMEDS EALGDAMALY EKYFSMQATN MIDLGSAIRA EMESLICEES
GRPNRKAFRT AKTACFFRLH DKYLSDFLKT SYYHNYLGEL QSFIDFTVEL PRKVRNRAAS
SSDVASSTDS LTHAFSRHLE VLEKKMNDKD ESTQTPTGSP SSSKRSTPRT PRSSRLAEVD
EMGRYHALYD DSHSQTPQKP MRIKSTLRKY LDKNTLREEE IAEEVARTII RDMQEMVASS
AESPTSPTFR YG
