ID   RGS5_PIG                Reviewed;         181 AA.
AC   Q864Z2;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Regulator of G-protein signaling 5;
DE            Short=RGS5;
GN   Name=RGS5;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Aorta;
RA   Weiss B., Hehlgans S.I., Wietelmann A.B., Zeyer A., Richter M.,
RA   Kloevekorn W.P., Zimmermann R., von der Ahe D.;
RT   "Differential gene expression in atherosclerotic coronary arteries.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into their
CC       inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to
CC       G(s)-alpha (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O15539}.
CC       Membrane {ECO:0000250|UniProtKB:O15539}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ549925; CAD71257.1; -; mRNA.
DR   RefSeq; NP_999521.1; NM_214356.1.
DR   AlphaFoldDB; Q864Z2; -.
DR   SMR; Q864Z2; -.
DR   STRING; 9823.ENSSSCP00000006753; -.
DR   PaxDb; Q864Z2; -.
DR   PRIDE; Q864Z2; -.
DR   Ensembl; ENSSSCT00000041659; ENSSSCP00000055403; ENSSSCG00000037821.
DR   Ensembl; ENSSSCT00005033102; ENSSSCP00005020177; ENSSSCG00005020906.
DR   Ensembl; ENSSSCT00015020965; ENSSSCP00015008245; ENSSSCG00015015788.
DR   Ensembl; ENSSSCT00025101795; ENSSSCP00025044992; ENSSSCG00025073877.
DR   Ensembl; ENSSSCT00030038508; ENSSSCP00030017704; ENSSSCG00030027538.
DR   Ensembl; ENSSSCT00035097653; ENSSSCP00035041214; ENSSSCG00035072160.
DR   Ensembl; ENSSSCT00045021069; ENSSSCP00045014511; ENSSSCG00045012373.
DR   Ensembl; ENSSSCT00055050271; ENSSSCP00055040170; ENSSSCG00055025395.
DR   Ensembl; ENSSSCT00065086024; ENSSSCP00065037610; ENSSSCG00065062699.
DR   Ensembl; ENSSSCT00070049761; ENSSSCP00070042015; ENSSSCG00070024889.
DR   GeneID; 397640; -.
DR   KEGG; ssc:397640; -.
DR   CTD; 8490; -.
DR   VGNC; VGNC:98844; RGS5.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000157380; -.
DR   HOGENOM; CLU_059863_3_0_1; -.
DR   InParanoid; Q864Z2; -.
DR   OMA; MAQKRIF; -.
DR   OrthoDB; 1416350at2759; -.
DR   TreeFam; TF315837; -.
DR   Reactome; R-SSC-416476; G alpha (q) signalling events.
DR   Reactome; R-SSC-418594; G alpha (i) signalling events.
DR   Proteomes; UP000008227; Chromosome 4.
DR   Proteomes; UP000314985; Chromosome 4.
DR   Bgee; ENSSSCG00000037821; Expressed in ovary and 41 other tissues.
DR   ExpressionAtlas; Q864Z2; baseline and differential.
DR   Genevisible; Q864Z2; SS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd08717; RGS_RGS5; 1.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR034955; RGS5.
DR   InterPro; IPR034956; RGS_RGS5.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF42; PTHR10845:SF42; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..181
FT                   /note="Regulator of G-protein signaling 5"
FT                   /id="PRO_0000204190"
FT   DOMAIN          64..180
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   181 AA;  21054 MW;  BEB98C7A4A99D669 CRC64;
     MCKGLAALPH SCLERAKEIK IKLGILLQKP ESAVDLVIPY NEKPDKPVKI QKPSLDEALQ
     WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWMACEDY KKIKSPVKMA EKAKKIYEEF
     IQSEAPKEVN IDHFTKEITM KNLVEPSPSS FDVAQKRIYA LMEKDSLPRF VRSEFYQEFI
     K