ID   RGS5_RAT                Reviewed;         181 AA.
AC   P49800; Q9JKD7;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2001, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Regulator of G-protein signaling 5;
DE            Short=RGS5;
GN   Name=Rgs5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kirsch T., Lippoldt A., Wellner M., Haller H.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 95-161.
RC   TISSUE=Brain;
RX   PubMed=8548815; DOI=10.1016/s0092-8674(00)80998-8;
RA   Koelle M.R., Horvitz H.R.;
RT   "EGL-10 regulates G protein signaling in the C. elegans nervous system and
RT   shares a conserved domain with many mammalian proteins.";
RL   Cell 84:115-125(1996).
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into their
CC       inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to
CC       G(s)-alpha (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O15539}.
CC       Membrane {ECO:0000250|UniProtKB:O15539}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF241259; AAF73424.1; -; mRNA.
DR   EMBL; U32435; AAC52372.1; -; mRNA.
DR   RefSeq; NP_062214.1; NM_019341.1.
DR   AlphaFoldDB; P49800; -.
DR   SMR; P49800; -.
DR   STRING; 10116.ENSRNOP00000003705; -.
DR   PaxDb; P49800; -.
DR   Ensembl; ENSRNOT00000079593; ENSRNOP00000069463; ENSRNOG00000002730.
DR   GeneID; 54294; -.
DR   KEGG; rno:54294; -.
DR   UCSC; RGD:3568; rat.
DR   CTD; 8490; -.
DR   RGD; 3568; Rgs5.
DR   eggNOG; KOG3589; Eukaryota.
DR   GeneTree; ENSGT00940000157380; -.
DR   InParanoid; P49800; -.
DR   OrthoDB; 1416350at2759; -.
DR   PhylomeDB; P49800; -.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:P49800; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:1904706; P:negative regulation of vascular associated smooth muscle cell proliferation; IDA:RGD.
DR   GO; GO:0007165; P:signal transduction; IDA:RGD.
DR   CDD; cd08717; RGS_RGS5; 1.
DR   Gene3D; 1.10.167.10; -; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR034955; RGS5.
DR   InterPro; IPR034956; RGS_RGS5.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF42; PTHR10845:SF42; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..181
FT                   /note="Regulator of G-protein signaling 5"
FT                   /id="PRO_0000204191"
FT   DOMAIN          64..180
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   181 AA;  21052 MW;  9C179CE008B82C03 CRC64;
     MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA HKPSLEEVLQ
     WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY KKIKSPIKMA EKAKQIYEEF
     IQTEAPKEVN IDHFTKDITM KNLVEPSPHS FDLAQKRIYA LMEKDSLPRF VRSEFYKELI
     N