RGS6_CAEEL
ID RGS6_CAEEL Reviewed; 734 AA.
AC Q18563; A0A078BPH3; A0A078BQK8; Q18562;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 25-APR-2018, sequence version 4.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Regulator of G-protein signaling rgs-6 {ECO:0000312|WormBase:C41G11.3a};
GN Name=rgs-6 {ECO:0000312|WormBase:C41G11.3a};
GN ORFNames=C41G11.3 {ECO:0000312|WormBase:C41G11.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=10950865;
RA Dong M.-Q., Chase D., Patikoglou G.A., Koelle M.R.;
RT "Multiple RGS proteins alter neural G protein signaling to allow C. elegans
RT to rapidly change behavior when fed.";
RL Genes Dev. 14:2003-2014(2000).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:C41G11.3a};
CC IsoId=Q18563-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:C41G11.3b};
CC IsoId=Q18563-2; Sequence=VSP_059557;
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DR EMBL; BX284606; CDX47458.1; -; Genomic_DNA.
DR EMBL; BX284606; CDX47459.1; -; Genomic_DNA.
DR PIR; T29512; T29512.
DR PIR; T29513; T29513.
DR RefSeq; NP_001294820.1; NM_001307891.1. [Q18563-1]
DR RefSeq; NP_001294821.1; NM_001307892.1. [Q18563-2]
DR AlphaFoldDB; Q18563; -.
DR SMR; Q18563; -.
DR STRING; 6239.C41G11.3; -.
DR EPD; Q18563; -.
DR PaxDb; Q18563; -.
DR PeptideAtlas; Q18563; -.
DR EnsemblMetazoa; C41G11.3a.1; C41G11.3a.1; WBGene00004349. [Q18563-1]
DR EnsemblMetazoa; C41G11.3a.2; C41G11.3a.2; WBGene00004349. [Q18563-1]
DR EnsemblMetazoa; C41G11.3a.3; C41G11.3a.3; WBGene00004349. [Q18563-1]
DR EnsemblMetazoa; C41G11.3b.1; C41G11.3b.1; WBGene00004349. [Q18563-2]
DR GeneID; 180840; -.
DR KEGG; cel:CELE_C41G11.3; -.
DR UCSC; C41G11.3; c. elegans. [Q18563-1]
DR CTD; 180840; -.
DR WormBase; C41G11.3a; CE50026; WBGene00004349; rgs-6. [Q18563-1]
DR WormBase; C41G11.3b; CE49999; WBGene00004349; rgs-6. [Q18563-2]
DR eggNOG; KOG3589; Eukaryota.
DR HOGENOM; CLU_384151_0_0_1; -.
DR InParanoid; Q18563; -.
DR OMA; YQHGDVA; -.
DR OrthoDB; 1384157at2759; -.
DR PhylomeDB; Q18563; -.
DR Reactome; R-CEL-416476; G alpha (q) signalling events.
DR Reactome; R-CEL-418594; G alpha (i) signalling events.
DR PRO; PR:Q18563; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00004349; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR Gene3D; 1.10.167.10; -; 1.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Alternative splicing; Reference proteome; Signal transduction inhibitor.
FT CHAIN 1..734
FT /note="Regulator of G-protein signaling rgs-6"
FT /evidence="ECO:0000305"
FT /id="PRO_0000204240"
FT DOMAIN 46..157
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 550..563
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_059557"
SQ SEQUENCE 734 AA; 79557 MW; 1A556C1C4651CCF5 CRC64;
MSTPCSGNEP ATPTNTSPNN ETSNSCLSMG VGVASNETNS SRELKIFKKV IRDPVLRAPF
QEFLEQQFCA ENLNFYLAVE QFKEIQDFQE RSSFGRRIFD RYFAMNSTEP VNIDNSTSKR
IRETVESGGF PLDTYDVAQY QILHLLKYDC WPRFLRSTNN SQPSFTDEEL AADDEDKNGH
SQPTSLNNTN EFEAAAQQSQ PAPNAPAATK EKPSKQYSMP AEMTSPVKKN SLSPTHLRRC
RPVEPKHCQL MIGDQFNTET VTLSDPTMSV RRWTQEMADA QGMDRMHVEV VDAETGSTID
PARQAIDALQ SRALRLVPVV SFIIEFLPAN FSFKNPASTP TKLVCIRARH SLSTGAVLRP
LLHKYTLDPQ VTRIVLNGSL EQVKRSCAVG QVSQKCLTVM SEAQYSDRVN AGKVSLPPRD
PILSQLPSTI YEQNNFPFHQ NGDISYCEIP NESERNKHAH LQHDGPNAAH QQKEYTLSIF
NKFVRKASHA VSKSDPNPSA GTSQDRMASG VYSPATGGPS FASRAAAGTN FGGSANQVNA
GSASTSSNNV SEPSKNRLSI FKSKTEKKVV KPESEKEKLK PRSDDIPTTS TSTPMAVETK
PNGSRTTEEP LKRMGKSGDD GSQEPQGIRH PAIFSTKIGD EAAAAAAGAS PSTSAPSTST
SVQTKTTTSP TKSPTSTTIT TSGTTTSATS SVATAPPPVL HAMRSASTPA TSSQLTGGGG
GNPRESSWQT AAYV
