RGS7_CAEEL
ID RGS7_CAEEL Reviewed; 819 AA.
AC Q8WQC0; Q95Q48; Q95Q49;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Regulator of G-protein signaling rgs-7;
DE AltName: Full=Protein C2-RGS;
DE AltName: Full=Regulator of G-protein signaling c2;
GN Name=rgs-7; ORFNames=F56B6.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C).
RX PubMed=12798417; DOI=10.1016/s0024-3205(03)00355-2;
RA Sato M., Moroi K., Nishiyama M., Zhou J., Usui H., Kasuya Y., Fukuda M.,
RA Kohara Y., Komuro I., Kimura S.;
RT "Characterization of a novel C. elegans RGS protein with a C2 domain:
RT evidence for direct association between C2 domain and Galphaq subunit.";
RL Life Sci. 73:917-932(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RA Hess H.A., Koelle M.R.;
RT "RGS-7 completes a receptor-independent G protein cycle to regulate
RT centrosome movements in Caenorhabditis elegans.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC activity of G protein alpha subunit egl-30 (G-alpha(q)), thereby
CC driving it into its inactive GDP-bound form. May organize egl-30 into a
CC stable multiprotein signaling complex, and thereby persistently inhibit
CC egl-30 when triggered by calcium or phospholipids.
CC -!- SUBUNIT: Interacts with egl-30.
CC -!- INTERACTION:
CC Q8WQC0; H2KZ17: dsh-1; NbExp=2; IntAct=EBI-6499941, EBI-2923230;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q8WQC0-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q8WQC0-2; Sequence=VSP_009312;
CC Name=c;
CC IsoId=Q8WQC0-3; Sequence=VSP_009311;
CC -!- DOMAIN: The C2 and the RGS domains are both required for its inhibitory
CC effect on G-protein signaling.
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DR EMBL; AB080201; BAB85494.1; -; mRNA.
DR EMBL; AY569308; AAS75452.1; -; mRNA.
DR EMBL; FO080515; CCD64313.1; -; Genomic_DNA.
DR EMBL; FO080515; CCD64315.1; -; Genomic_DNA.
DR EMBL; FO080515; CCD64314.1; -; Genomic_DNA.
DR RefSeq; NP_001024714.1; NM_001029543.2. [Q8WQC0-3]
DR RefSeq; NP_001024715.1; NM_001029544.3. [Q8WQC0-2]
DR RefSeq; NP_508610.3; NM_076209.4. [Q8WQC0-1]
DR AlphaFoldDB; Q8WQC0; -.
DR SMR; Q8WQC0; -.
DR BioGRID; 45583; 6.
DR IntAct; Q8WQC0; 3.
DR STRING; 6239.F56B6.2a; -.
DR iPTMnet; Q8WQC0; -.
DR EPD; Q8WQC0; -.
DR PaxDb; Q8WQC0; -.
DR PRIDE; Q8WQC0; -.
DR EnsemblMetazoa; F56B6.2a.1; F56B6.2a.1; WBGene00004350. [Q8WQC0-1]
DR EnsemblMetazoa; F56B6.2b.1; F56B6.2b.1; WBGene00004350. [Q8WQC0-3]
DR EnsemblMetazoa; F56B6.2c.1; F56B6.2c.1; WBGene00004350. [Q8WQC0-2]
DR GeneID; 180645; -.
DR UCSC; F56B6.2a; c. elegans. [Q8WQC0-1]
DR CTD; 180645; -.
DR WormBase; F56B6.2a; CE29403; WBGene00004350; rgs-7. [Q8WQC0-1]
DR WormBase; F56B6.2b; CE30151; WBGene00004350; rgs-7. [Q8WQC0-3]
DR WormBase; F56B6.2c; CE29404; WBGene00004350; rgs-7. [Q8WQC0-2]
DR eggNOG; KOG3589; Eukaryota.
DR HOGENOM; CLU_358341_0_0_1; -.
DR InParanoid; Q8WQC0; -.
DR OrthoDB; 1409647at2759; -.
DR Reactome; R-CEL-416476; G alpha (q) signalling events.
DR Reactome; R-CEL-418594; G alpha (i) signalling events.
DR PRO; PR:Q8WQC0; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00004350; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; Q8WQC0; baseline and differential.
DR GO; GO:0005938; C:cell cortex; IDA:WormBase.
DR GO; GO:0005096; F:GTPase activator activity; IDA:WormBase.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50132; RGS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Signal transduction inhibitor.
FT CHAIN 1..819
FT /note="Regulator of G-protein signaling rgs-7"
FT /id="PRO_0000204241"
FT DOMAIN 290..429
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 682..800
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..395
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_009312"
FT VAR_SEQ 1..53
FT /note="MSDEDADEYDDQSSISSVSDDDDFSGSESESYQDTTESTGPSEATTDEMLWG
FT R -> MTYTVRTKTKGLEALI (in isoform c)"
FT /evidence="ECO:0000303|PubMed:12798417"
FT /id="VSP_009311"
SQ SEQUENCE 819 AA; 92590 MW; A84B6B5F805CC6B5 CRC64;
MSDEDADEYD DQSSISSVSD DDDFSGSESE SYQDTTESTG PSEATTDEML WGRRRAPVCG
IAAQAVRRQI LMNQQHEPNV LGNNKKVYQT FGSTPQLANE RHKEMYSQIR RGDDSSFRSR
DRFVPPRRPR MGYGSSDLSA IEEMSPIRSS TYSSSSEAHR LSSLRAQTEW KPQLTSTTTS
FQPLSPMNHH DKENGPFKAP MSPVCSSTPR SQRMYRKNPK YRRQFGSSLQ LSESRLEEST
SQESERAVTP ESWMEHNNEN EHPDQMMFAK PKQGSFPRPE AFGLDNAYAK HKDIRGIIFL
SMSLCGRRLT LNVQNAAYFC SAARPTSVCS YVSAVLCHRP SSQSSSSSRQ YRQRPDECYR
TRLVTNCNSP SFDESFYFTF SENCVRDLLI VTVYEMDSNN AEKKRILGCM TFPVSRILKK
ASQVVGDPFP HYRRQDPMED VEINNEGFFL LNKDQGRKQN FPQRKVRRQT FYEDPAFTGV
SSAGSSVISN NTGGQMTMAS PRLSVPNELT MGDYYRSTGS SDMRGRSTNN LLDYTSASSS
TNGSAGGPEK LKLHRATLPS ITTTTSENNS DDAKSLSPEQ SPTDHHFLCP DDNGGVYGAG
PAHSAIKKSS VRRAASFTFS PKHSSSKTNL RQLNGREEDK EKKRFLGPIS RTLSYLRSKM
DLALSTSSLY PSRDDVRQWE ISFESLLNNK FGCALFRQFL KKEFSDENMD FWLECEEFKK
MKDGKKSTTQ KAIEIYSEFV AEHSPKEVNL DSDTRAATKA AVEAGCKPDT FALAQSRVEQ
LMSKDSYRRF LRDRLFLDLL ESYEITDKED KPSSSKDKN
