ID   RGS8_DANRE              Reviewed;         174 AA.
AC   Q6DGI0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Regulator of G-protein signaling 8;
DE            Short=RGS8;
GN   Name=rgs8; ORFNames=zgc:92913;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates G protein-coupled receptor signaling cascades,
CC       including signaling via muscarinic acetylcholine receptors and dopamine
CC       receptors. Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits, thereby driving them into their
CC       inactive GDP-bound form. Modulates the activity of potassium channels
CC       that are activated in response to G protein-coupled receptor signaling.
CC       {ECO:0000250|UniProtKB:P49804}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P49804};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic
CC       side {ECO:0000250|UniProtKB:P49804}. Membrane
CC       {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:P49804}. Perikaryon
CC       {ECO:0000250|UniProtKB:P49804}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:P49804}. Nucleus {ECO:0000250|UniProtKB:P49804}.
CC       Note=Detected in Purkinje cell soma and dendrites. Associated with
CC       Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected
CC       in the nucleus after heterologous expression. Recruited to the cell
CC       membrane in the presence of GNAO1. {ECO:0000250|UniProtKB:P49804}.
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DR   EMBL; BC076365; AAH76365.1; -; mRNA.
DR   RefSeq; NP_001002531.1; NM_001002531.1.
DR   AlphaFoldDB; Q6DGI0; -.
DR   SMR; Q6DGI0; -.
DR   STRING; 7955.ENSDARP00000093238; -.
DR   PaxDb; Q6DGI0; -.
DR   GeneID; 436804; -.
DR   KEGG; dre:436804; -.
DR   CTD; 85397; -.
DR   ZFIN; ZDB-GENE-040718-264; rgs8.
DR   eggNOG; KOG3589; Eukaryota.
DR   InParanoid; Q6DGI0; -.
DR   OrthoDB; 1295370at2759; -.
DR   PhylomeDB; Q6DGI0; -.
DR   Reactome; R-DRE-416476; G alpha (q) signalling events.
DR   Reactome; R-DRE-418594; G alpha (i) signalling events.
DR   Reactome; R-DRE-418597; G alpha (z) signalling events.
DR   PRO; PR:Q6DGI0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR   GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0032809; C:neuronal cell body membrane; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0007213; P:G protein-coupled acetylcholine receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0060159; P:regulation of dopamine receptor signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.10.167.10; -; 1.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR034948; RGS8.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845:SF147; PTHR10845:SF147; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; GTPase activation; Membrane; Nucleus;
KW   Reference proteome; Signal transduction inhibitor.
FT   CHAIN           1..174
FT                   /note="Regulator of G-protein signaling 8"
FT                   /id="PRO_0000364204"
FT   DOMAIN          46..162
FT                   /note="RGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
SQ   SEQUENCE   174 AA;  20521 MW;  DA142784D6FFD833 CRC64;
     MKTRLGCLSN KSDSCSDFSE FLPPAQERTT RCLKLSNDEV TRWADSFDIL LSNKYGLAAF
     RTFLKTEFSD ENIEFWLACE DYKKIKSPAK MMSKANKIYK EFIDVHAPRE VNIDHRTREE
     TKNRLLEPTP HSLNEVQAKV YSLMEKDSYP RFIRSKIYQD LLNRTQIYCQ RKSV