RGS8_MACFA
ID RGS8_MACFA Reviewed; 196 AA.
AC Q95K68;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Regulator of G-protein signaling 8;
DE Short=RGS8;
GN Name=RGS8; ORFNames=QmoA-10247;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Medulla oblongata;
RX PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Prediction of unidentified human genes on the basis of sequence similarity
RT to novel cDNAs from cynomolgus monkey brain.";
RL Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC -!- FUNCTION: Regulates G protein-coupled receptor signaling cascades,
CC including signaling via muscarinic acetylcholine receptor CHRM2 and
CC dopamine receptor DRD2. Inhibits signal transduction by increasing the
CC GTPase activity of G protein alpha subunits, thereby driving them into
CC their inactive GDP-bound form. Modulates the activity of potassium
CC channels that are activated in response to DRD2 and CHRM2 signaling.
CC {ECO:0000250|UniProtKB:P49804}.
CC -!- SUBUNIT: Interacts with GNAO1 and GNAI3.
CC {ECO:0000250|UniProtKB:P49804}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P49804};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic
CC side {ECO:0000250|UniProtKB:P49804}. Membrane
CC {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P49804}. Perikaryon
CC {ECO:0000250|UniProtKB:P49804}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:P49804}. Nucleus {ECO:0000250|UniProtKB:P49804}.
CC Note=Detected in Purkinje cell soma and dendrites. Associated with
CC Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected
CC in the nucleus after heterologous expression. Recruited to the cell
CC membrane in the presence of GNAO1. {ECO:0000250|UniProtKB:P49804}.
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DR EMBL; AB066513; BAB62198.1; -; mRNA.
DR AlphaFoldDB; Q95K68; -.
DR SMR; Q95K68; -.
DR STRING; 9541.XP_005540232.1; -.
DR VEuPathDB; HostDB:ENSMFAG00000035700; -.
DR eggNOG; KOG3589; Eukaryota.
DR OMA; WSESFDS; -.
DR Proteomes; UP000233100; Chromosome 1.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB.
DR GO; GO:0032809; C:neuronal cell body membrane; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR GO; GO:0007213; P:G protein-coupled acetylcholine receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR GO; GO:0060159; P:regulation of dopamine receptor signaling pathway; ISS:UniProtKB.
DR CDD; cd08711; RGS_RGS8; 1.
DR Gene3D; 1.10.167.10; -; 1.
DR Gene3D; 1.10.196.10; -; 2.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR034948; RGS8.
DR InterPro; IPR034949; RGS_RGS8.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR10845:SF147; PTHR10845:SF147; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 1.
DR PROSITE; PS50132; RGS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; GTPase activation; Membrane; Nucleus;
KW Phosphoprotein; Reference proteome; Signal transduction inhibitor.
FT CHAIN 1..196
FT /note="Regulator of G-protein signaling 8"
FT /id="PRO_0000364203"
FT DOMAIN 72..188
FT /note="RGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00171"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P49804"
SQ SEQUENCE 196 AA; 22939 MW; A42C6D41A9244064 CRC64;
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALNYLRMYKF TATELQESRR
LSTEEATRWA DSFDVLLSHK YGVAAFRAFL KTEFSEENLE FWLACEEFKK TRSTAKLVSK
AHRIFEEFVD VQAPREVNID FQTREATRKN MQEPSLTCFD QAQGKVHSLM EKDSYPRFLR
SKMYLDLLSQ SQRRLS
