RGSL_HUMAN
ID RGSL_HUMAN Reviewed; 1076 AA.
AC A5PLK6; A2A2Z0; A6PVM2; A6PVM3; Q0VAJ4; Q0VAJ5; Q6ZRL0; Q86UV0; Q9H084;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Regulator of G-protein signaling protein-like;
GN Name=RGSL1; Synonyms=RGSL, RGSL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RA Silva A.P.M., Caballero O., de Souza S.J., Simpson A.J.G., Camargo A.A.;
RT "Identification of 17 additional transcripts within the hereditary prostate
RT cancer locus (HPC1) at 1q25.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=A5PLK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A5PLK6-2; Sequence=VSP_035348;
CC Name=3;
CC IsoId=A5PLK6-3; Sequence=VSP_035347;
CC Name=4;
CC IsoId=A5PLK6-4; Sequence=VSP_035347, VSP_035354;
CC Name=5;
CC IsoId=A5PLK6-5; Sequence=VSP_035348, VSP_035352, VSP_035353;
CC Name=6;
CC IsoId=A5PLK6-6; Sequence=VSP_035349, VSP_035350, VSP_035351;
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DR EMBL; AF510428; AAP30864.1; -; mRNA.
DR EMBL; AL136902; CAB66836.1; -; mRNA.
DR EMBL; AK128152; BAC87300.1; -; mRNA.
DR EMBL; AL138776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW91125.1; -; Genomic_DNA.
DR EMBL; BC121032; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC121033; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC142944; AAI42945.1; -; mRNA.
DR CCDS; CCDS58049.1; -. [A5PLK6-1]
DR RefSeq; NP_001131141.1; NM_001137669.1. [A5PLK6-1]
DR RefSeq; XP_016856684.1; XM_017001195.1.
DR RefSeq; XP_016856685.1; XM_017001196.1. [A5PLK6-2]
DR AlphaFoldDB; A5PLK6; -.
DR BioGRID; 131681; 5.
DR IntAct; A5PLK6; 3.
DR STRING; 9606.ENSP00000457748; -.
DR iPTMnet; A5PLK6; -.
DR PhosphoSitePlus; A5PLK6; -.
DR BioMuta; RGSL1; -.
DR jPOST; A5PLK6; -.
DR MassIVE; A5PLK6; -.
DR PaxDb; A5PLK6; -.
DR PeptideAtlas; A5PLK6; -.
DR PRIDE; A5PLK6; -.
DR ProteomicsDB; 731; -. [A5PLK6-1]
DR ProteomicsDB; 732; -. [A5PLK6-2]
DR ProteomicsDB; 733; -. [A5PLK6-3]
DR ProteomicsDB; 734; -. [A5PLK6-4]
DR ProteomicsDB; 735; -. [A5PLK6-5]
DR ProteomicsDB; 736; -. [A5PLK6-6]
DR Antibodypedia; 72237; 7 antibodies from 7 providers.
DR DNASU; 353299; -.
DR Ensembl; ENST00000294854.13; ENSP00000457748.1; ENSG00000121446.20. [A5PLK6-1]
DR GeneID; 353299; -.
DR KEGG; hsa:353299; -.
DR MANE-Select; ENST00000294854.13; ENSP00000457748.1; NM_001137669.2; NP_001131141.1.
DR UCSC; uc009wxw.5; human. [A5PLK6-1]
DR CTD; 353299; -.
DR DisGeNET; 353299; -.
DR GeneCards; RGSL1; -.
DR HGNC; HGNC:18636; RGSL1.
DR HPA; ENSG00000121446; Tissue enriched (testis).
DR MIM; 611012; gene.
DR MIM; 611013; gene.
DR neXtProt; NX_A5PLK6; -.
DR OpenTargets; ENSG00000121446; -.
DR PharmGKB; PA134870196; -.
DR VEuPathDB; HostDB:ENSG00000121446; -.
DR eggNOG; ENOG502QPIJ; Eukaryota.
DR GeneTree; ENSGT00660000095605; -.
DR HOGENOM; CLU_295893_0_0_1; -.
DR InParanoid; A5PLK6; -.
DR OMA; SVCYTHV; -.
DR OrthoDB; 204702at2759; -.
DR PhylomeDB; A5PLK6; -.
DR TreeFam; TF336510; -.
DR PathwayCommons; A5PLK6; -.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-418597; G alpha (z) signalling events.
DR SignaLink; A5PLK6; -.
DR BioGRID-ORCS; 353299; 9 hits in 1063 CRISPR screens.
DR ChiTaRS; RGSL1; human.
DR GenomeRNAi; 353299; -.
DR Pharos; A5PLK6; Tdark.
DR PRO; PR:A5PLK6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A5PLK6; protein.
DR Bgee; ENSG00000121446; Expressed in left testis and 72 other tissues.
DR ExpressionAtlas; A5PLK6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.167.10; -; 1.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR Pfam; PF00615; RGS; 1.
DR SUPFAM; SSF48097; SSF48097; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1076
FT /note="Regulator of G-protein signaling protein-like"
FT /id="PRO_0000349305"
FT TRANSMEM 960..982
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 645..764
FT /note="RGS"
FT REGION 834..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..576
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_035347"
FT VAR_SEQ 1..477
FT /note="Missing (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035348"
FT VAR_SEQ 100
FT /note="G -> GAKMMRWKKADQWLLQKCIGGVRGMWRFYSYLTGSA (in
FT isoform 6)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_035349"
FT VAR_SEQ 499..504
FT /note="TQNRFI -> VGRTLG (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_035350"
FT VAR_SEQ 505..1076
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_035351"
FT VAR_SEQ 938..949
FT /note="NVPEFQKDAILA -> LFLEGNPLLLTV (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035352"
FT VAR_SEQ 950..1076
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035353"
FT VAR_SEQ 979..1076
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_035354"
FT VARIANT 5
FT /note="E -> D (in dbSNP:rs12083859)"
FT /id="VAR_046356"
FT VARIANT 256
FT /note="W -> C (in dbSNP:rs647224)"
FT /id="VAR_046357"
FT CONFLICT 683
FT /note="I -> V (in Ref. 6; BC121032/BC121033)"
FT /evidence="ECO:0000305"
FT CONFLICT 823
FT /note="H -> L (in Ref. 6; BC121032)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1076 AA; 125688 MW; 7B398FB2DAA2C7E7 CRC64;
MSSAEIIGST NLIILLEDEV FADFFNTFLS LPVFGQTPFY TVENSQWSLW PEIPCNLIAK
YKGLLTWLEK CRLPFFCKTN LCFHYILCQE FISFIKSPEG GEELVDFWIL AENILSIDEM
DLEVRDYYLS LLLMLRATHL QEGSRVVTLC NMNIKSLLNL SIWHPNQSTT RREILSHMQK
VALFKLQSYW LPNFYTHTKM TMAKEEACHG LMQEYETRLY SVCYTHIGGL PLNMSIKKCH
HFQKRYSSRK AKRKMWQLVD PDSWSLEMDL KPDAIGMPLQ ETCPQEKVVI QMPSLKMASS
KETRISSLEK DMHYAKISSM ENKAKSHLHM EAPFETKVST HLRTVIPIVN HSSKMTIQKA
IKQSFSLGYI HLALCADACA GNPFRDHLKK LNLKVEIQLL DLWQDLQHFL SVLLNNKKNG
NAIFRHLLGD RICELYLNEQ IGPCLPLKSQ TIQGLKELLP SGDVIPWIPK AQKEICKMLS
PWYDEFLDEE DYWFLLFTTQ NRFISSRQHK REFIGKEENI LLYKRIQQSL ELSQALADMK
EMDYRQWRKI ATEDLKQGGS LQVELTSPVF LTDITKMSFE ELCYKNPKMA IQKISDDYKI
YCEKAPKIDF KMEIIKETKT VSRSNRKMSL LKRTLVRKPS MRPRNLTEVL LNTQHLEFFR
EFLKERKAKI PLQFLTAVQK ISIETNEKIC KSLIENVIKT FFQGQLSPEE MLQCDAPIIK
EIASMRHVTT STLLTLQGHV MKSIEEKWFK DYQDLFPPHH QEVEVQSEVQ ISSRKPSKIV
STYLQESQKK GWMRMISFIR SFCKYRRFML NPSKRQEFED YLHQEMQNSK ENFTTAHNTS
GRSAPPSTNV RSADQENGEI TLVKRRIFGH RIITVNFAIN DLYFFSEMEK FNDLVSSAHM
LQVNRAYNEN DVILMRSKMN IIQKLFLNSD IPPKLRVNVP EFQKDAILAA ITEGYLDRSV
FHGAIMSVFP VVMYFWKRFC FWKATRSYLQ YRGKKFKDRK SPPKSTDKYP FSSGGDNAIL
RFTLLRGIEW LQPQREAISS VQNSSSSKLT QPRLVVSAMQ LHPVQGQKLS YIKKEK
