RGT1_ASHGO
ID RGT1_ASHGO Reviewed; 856 AA.
AC Q750N3;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Glucose transport transcription regulator RGT1;
DE AltName: Full=Restores glucose transport protein 1;
GN Name=RGT1; OrderedLocusNames=AGL083W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Glucose-responsive transcription factor that regulates
CC expression of several glucose transporter (HXT) genes in response to
CC glucose. In the absence of glucose, it functions as a transcriptional
CC repressor, whereas high concentrations of glucose cause it to function
CC as a transcriptional activator. In cells growing on low levels of
CC glucose, has a neutral role, neither repressing nor activating
CC transcription (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EDS1/RGT1 family. {ECO:0000305}.
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DR EMBL; AE016820; AAS54407.1; -; Genomic_DNA.
DR RefSeq; NP_986583.1; NM_211645.1.
DR AlphaFoldDB; Q750N3; -.
DR STRING; 33169.AAS54407; -.
DR EnsemblFungi; AAS54407; AAS54407; AGOS_AGL083W.
DR GeneID; 4622882; -.
DR KEGG; ago:AGOS_AGL083W; -.
DR eggNOG; ENOG502QRVJ; Eukaryota.
DR HOGENOM; CLU_006525_0_0_1; -.
DR InParanoid; Q750N3; -.
DR OMA; HILENCC; -.
DR Proteomes; UP000000591; Chromosome VII.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc.
FT CHAIN 1..856
FT /note="Glucose transport transcription regulator RGT1"
FT /id="PRO_0000408012"
FT DNA_BIND 46..75
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 92978 MW; 56A782F249045294 CRC64;
MNGATATATA AVGAEEEGGA REGSRRRDSV ESAGDGRRRT KVSRACDQCR RKKIKCEYQE
DAQSCSGCRK NSERCAFERV PLKRGPSKGY TRGEGAGDGA RETEGARGEL DTSRADGKAA
PVSLPPLHYY LPISNGQPGG APAQAPAAPF PPMKQQFWKV PYYENQMQRR SSLESVNSDA
SGPQSQQETY AASSASTSSH QRTSRSYFPS SDGASALFQE PCSSSYPPPL VRSSSTGGQL
QQLPAPQYPY SQFAVALSGS TSASSQSVQL RTSATGSTSL PEDSSPSSSN AYSPQLRAHC
MSESLTTPTA GSKTGGSVKR RKRLSEPADP IVPLSAREPR QAGHIGLPLQ AQQATGKTGV
ICGKLSDAEL IDAYYEYVHV NYPIIPINKE TLTNEILLVN TQPISEVHEM NNYILYWFRV
ALELLLHVAS DKTNQDTASG MDSNAVHDGG LYAHRGDFKQ NEEHHVPHQS QLLAALNDCF
RKLLDIHPKI CAYQESTSPK VTTIYLSTYI IINYMLAMLG EDNTFVLGTS VTVFNEFKIY
RLLVLHEVAD EPGDDSADVE RHGFELLYKR LYYSLLVFDA LQSCCFGAPR LASLPISHLV
EPLFAPPPPL DSAKWAVESD AARREPLLAS IRLGALLTEL CETRVLAGAL PRAPTPALRA
PRPFRVAPPA DDSVPGAFFH ALAAQRALLD RLLAIPAHPA FAADAPPDAT VDLCAQLGDA
ICRFTSCVLD TLVRAGPRPA SPFAAALSRA LHHAINLSRN IPTSLIGCII GTAVHHSRDR
DLIVALSRCM SDMIQIQGLT HCLRPCAPPR PRARVSCDLR RLYGHDGPPA SPHQVMLHQF
IDIAWRLLRN DELGWF
