ID   RGT1_KLULA              Reviewed;        1007 AA.
AC   Q6CIL8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Glucose transport transcription regulator RGT1;
DE   AltName: Full=Restores glucose transport protein 1;
GN   Name=RGT1; OrderedLocusNames=KLLA0F25630g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Glucose-responsive transcription factor that regulates
CC       expression of several glucose transporter (HXT) genes in response to
CC       glucose. In the absence of glucose, it functions as a transcriptional
CC       repressor, whereas high concentrations of glucose cause it to function
CC       as a transcriptional activator. In cells growing on low levels of
CC       glucose, has a neutral role, neither repressing nor activating
CC       transcription (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC       Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EDS1/RGT1 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98929.1; -; Genomic_DNA.
DR   RefSeq; XP_456221.1; XM_456221.1.
DR   AlphaFoldDB; Q6CIL8; -.
DR   STRING; 28985.XP_456221.1; -.
DR   PRIDE; Q6CIL8; -.
DR   EnsemblFungi; CAG98929; CAG98929; KLLA0_F25630g.
DR   GeneID; 2895143; -.
DR   KEGG; kla:KLLA0_F25630g; -.
DR   eggNOG; ENOG502QRVJ; Eukaryota.
DR   HOGENOM; CLU_006525_0_0_1; -.
DR   InParanoid; Q6CIL8; -.
DR   OMA; WFRNSLE; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:EnsemblFungi.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:EnsemblFungi.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:EnsemblFungi.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc.
FT   CHAIN           1..1007
FT                   /note="Glucose transport transcription regulator RGT1"
FT                   /id="PRO_0000408014"
FT   DNA_BIND        117..151
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..189
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..343
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1007 AA;  112261 MW;  37D96CDB8652A74B CRC64;
     MLSALIQNGM SKSGDPTDVE NNTTNGSSST TDNANDVGRG VNTENNSKLE NDSSNAATIT
     TSKQDPSAVD EATTPRSINT GASTVPEPDN TRRDSVSSNV STATTESRRR SKVSRACDQC
     RKKKIKCDFI EGHDINPDQS CTGCRKIGEK CSFERIPLKR GPSKGYTRSN SQSRERRGSQ
     RRRSSSEVSQ KGKKPSVSNP VNAVNESKSE VDASLHPGQS ATSTTNVSLH PLLQYLPGMN
     HSAVSASSPS ALQQPFWKVP YHEYQNQRRP SLDSLASDSS QKPGGKTNQQ QPLPSQSQPQ
     SLQNIGNSRS NTGPLPTQDT FRNQRYYYQP SQDSVSEAGS DNRRGSSAIP PLLNPAIQLQ
     QQQYSYSQFA IAQQQQQQQQ QQQQQQLQLQ QHLQQQHQLQ QQQSLHSPQA NTMNASTGIS
     NGGFVPYSGN KGLPSGGHVL ERTDSVASDA MSLNASPNIY TAEVESAPAS PVQKKRKRSN
     RSSTSKKGKS TQQNLPATTP TLINYGQIAD AQLIDTYYAY IHLRFPIIPI NKDTLTNDLL
     LVNTQPISEL HELNNYILLW FRNSLELLIR ICLKDKESEE ILYQQSTFVS AINECFQKIV
     DIHPRFRDLE TQIDEKIATI YLVTFIILNC TLALVSYNNS FVLGMSVIIF NELKLWKNFI
     FGNWNTVTGH DKICLRLYFE LNTFDSLQSC SFGVPKLMNL KLDETTASKL FYDEVSNDGT
     GQETDKWNVD EDPERIRIIV DNMELGYFLS RLCQARRSSF EKPLPLVGEH NENKTIPGLF
     RAFLSIKRQF TDTLLDLPDA EGKLPEMTPE LVTRLSNMIC DLTTTIHDLL KLNVEVNPTN
     CLELFPDNSM QTVDESSAHN SAAQSSDPSN IEVGTVSPYV IAIYKDLFNV VELIKNMPTS
     LIGCVMGTQA PNFDSQPLVL QLSQCMNNML QITTFTSSLS PFKIFKHELN AQSKNKTIDA
     VPLWKQKMKS SLAPLQTAIT PQEIMMAQFI DIAWCIADTE ELGWFNQ