ID   RGT1_ZYGRC              Reviewed;        1066 AA.
AC   C5E4G1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Glucose transport transcription regulator RGT1;
DE   AltName: Full=Restores glucose transport protein 1;
GN   Name=RGT1; OrderedLocusNames=ZYRO0E05676g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Glucose-responsive transcription factor that regulates
CC       expression of several glucose transporter (HXT) genes in response to
CC       glucose. In the absence of glucose, it functions as a transcriptional
CC       repressor, whereas high concentrations of glucose cause it to function
CC       as a transcriptional activator. In cells growing on low levels of
CC       glucose, has a neutral role, neither repressing nor activating
CC       transcription (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC       Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EDS1/RGT1 family. {ECO:0000305}.
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DR   EMBL; CU928181; CAR30922.1; -; Genomic_DNA.
DR   RefSeq; XP_002499177.1; XM_002499132.1.
DR   AlphaFoldDB; C5E4G1; -.
DR   STRING; 559307.C5E4G1; -.
DR   EnsemblFungi; CAR30922; CAR30922; ZYRO0E05676g.
DR   GeneID; 8204730; -.
DR   KEGG; zro:ZYRO0E05676g; -.
DR   HOGENOM; CLU_006525_0_0_1; -.
DR   InParanoid; C5E4G1; -.
DR   Proteomes; UP000008536; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc.
FT   CHAIN           1..1066
FT                   /note="Glucose transport transcription regulator RGT1"
FT                   /id="PRO_0000408020"
FT   DNA_BIND        68..97
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          616..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          849..871
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..645
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1066 AA;  118463 MW;  A7D074185906329E CRC64;
     MTPMSENNGS ENTRDVSAAM MKSRSNSSEY AGGDGSFHAS EVESQSSQGA SGGNTSASKR
     RTKASRACDQ CRKRKIRCDY DDDKGVCTSC RKNGESCAFE RIQLKRGPSK GAVRGHSVSR
     SISGENNNTA ATAVGSGGEF SSPSSRQGSV LLPPLGQYLP QPAPVPSNLN ATQQQQFWKV
     PYHDFQGQRR GSIDSLSSDM SAKSVNIPQE HLLYASPSAG HPPLHSPVTF GPNNSSTDSG
     YWPFRNSGGE ESDELRRKSG SNPPSLKNVS QPPPPPLQQQ QQQQYSYSKF NNSFAQYGAN
     GFPSRHGSIA SEGMSPSASV PYQSVPMNQS NSNGLSQQQQ QPIQWPKVQP KNLPPPQVQV
     QAADKEETLG NSFQKTIKKR RTVSASSGEN KAEPGEYPLA RFSSSGNDSL LGGNLVSPAG
     FVYGQIPEIQ LIDIYYEFIH MVFPIIPLNK ETVTNEILLV NTQPISPIHE INNYVILWFR
     NSLELLIRIT LKRRSGHFYD SLTHSKEREL SNEIRGNSNG GGSNDSKDDN LEMQGVFVTA
     LNECLQKIVD IHPSFRENKD KISPKVKIIY LSTFVLLNYI LAVVGYDNSF VLGMSTTIFK
     DFKVYELLLY DDEDDDATKS GSNDNDNTNN DNNSNNANND NNDSRFYDEN NAMNWDQAGY
     SITFKRLYVL LIIFDSLQCC SYGGPKLLNV PIEGASERFF QTKPHSNSKW VVDQSPTRMK
     FILQSVKFGE LLAECSMKRR SICDLSRTQL TWEIPPYFLK GVTDEDDELF SLAQLLAAFI
     LIRKEFVDCL LNLQDLETGE LPTVDMELCG ELIKLLCQLT SIILQALTVM MRTNPKNHID
     YNYRPMKPME HDDSGNSASR KFTTSQAESG KNSGNDFYHK LLGLQDNAEA CLTNLLRGSI
     SPYCISMLRE IRNVMELVKK MPASLIGVVM ACAGTHHNTA NNNNNDPLAI TFQSQELVVK
     LSNCMNDMMQ ITSLLNMIKP VNLSDQDSDN TSATATITTT ETISKSLNRD HSIMRRLYYS
     KAAKRDKKHI YPSSSSSPQL QETITTLKSF VLIGWKLLDD FELGWS