ID   RH17_ARATH              Reviewed;         609 AA.
AC   Q7XJN0; Q9ZS04;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=DEAD-box ATP-dependent RNA helicase 17;
DE            EC=3.6.4.13;
GN   Name=RH17; OrderedLocusNames=At2g40700; ORFNames=T7D17.12;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 312-609.
RC   STRAIN=cv. Columbia;
RX   PubMed=9862990; DOI=10.1093/nar/27.2.628;
RA   Aubourg S., Kreis M., Lecharny A.;
RT   "The DEAD box RNA helicase family in Arabidopsis thaliana.";
RL   Nucleic Acids Res. 27:628-636(1999).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=17168887; DOI=10.1111/j.1467-7652.2004.00084.x;
RA   Mingam A., Toffano-Nioche C., Brunaud V., Boudet N., Kreis M., Lecharny A.;
RT   "DEAD-box RNA helicases in Arabidopsis thaliana: establishing a link
RT   between quantitative expression, gene structure and evolution of a family
RT   of genes.";
RL   Plant Biotechnol. J. 2:401-415(2004).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=24265739; DOI=10.1371/journal.pone.0078982;
RA   Xu R., Zhang S., Huang J., Zheng C.;
RT   "Genome-wide comparative in silico analysis of the RNA helicase gene family
RT   in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza
RT   sativa.";
RL   PLoS ONE 8:E78982-E78982(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC       family of RNA helicases and controls ATP binding and hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX31/DBP7
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ010468; CAA09207.1; -; mRNA.
DR   PIR; G84832; G84832.
DR   PIR; T51746; T51746.
DR   AlphaFoldDB; Q7XJN0; -.
DR   SMR; Q7XJN0; -.
DR   STRING; 3702.AT2G40700.1; -.
DR   iPTMnet; Q7XJN0; -.
DR   PaxDb; Q7XJN0; -.
DR   PeptideAtlas; Q7XJN0; -.
DR   PRIDE; Q7XJN0; -.
DR   EnsemblPlants; AT2G40700.1; AT2G40700.1; AT2G40700.
DR   Gramene; AT2G40700.1; AT2G40700.1; AT2G40700.
DR   Araport; AT2G40700; -.
DR   TAIR; locus:2064844; AT2G40700.
DR   eggNOG; KOG0348; Eukaryota.
DR   HOGENOM; CLU_003041_26_2_1; -.
DR   InParanoid; Q7XJN0; -.
DR   OMA; AVHIKAD; -.
DR   PhylomeDB; Q7XJN0; -.
DR   PRO; PR:Q7XJN0; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q7XJN0; baseline and differential.
DR   Genevisible; Q7XJN0; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009651; P:response to salt stress; IMP:TAIR.
DR   GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..609
FT                   /note="DEAD-box ATP-dependent RNA helicase 17"
FT                   /id="PRO_0000239159"
FT   DOMAIN          61..255
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          314..491
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          566..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           29..58
FT                   /note="Q motif"
FT   MOTIF           187..190
FT                   /note="DEAD box"
FT   COMPBIAS        569..586
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..601
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         74..81
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   609 AA;  68214 MW;  0AB50FD42FE50DA0 CRC64;
     MKRAQQSARE TKQEAKDASK AKSGLFASCS FSSLGLDTKL SDQLKERMGF EAPTLVQAQA
     IPVILSGRDV LVNAPTGTGK TIAYLAPLIH HLQGHSPKVD RSHGTFALVI VPTRELCLQV
     YETLEKLLHR FHWIVPGYVM GGEKKAKEKA RLRKGISILI ATPGRLLDHL KNTASFVHKN
     LRWVIFDEAD SILELGYGKE IEQIIKLLGS GQNEQGEEDD IVPKGIQKQN LLLSATLNDK
     VNDLAKLSLD DPVMIGLDNT KLQQNLSIES PAAPDSDAED MVIHVNKSAN PLSEDYGIPS
     QLVQRYLRVP CGARLVALLS VLKNLFEREA SQKVVVFFST RDAVDFHYSL LSEFQWPPNS
     ETEEEGTKEL FLKCKTFRLH GSMEQEDRRS AFGTFKTEKQ AVLLSTDVAA RGLDFPKVRC
     IIQYDCPGEA TEYVHRVGRT ARIGEKGEAL LFLQPIEIDY LKELKKHGAS LTEYPLMKVL
     DKFPIPGNMP RIKKVLSLES HPWVISLQRA LESLTYAEPK MKSLAKNAFV SWVRGYAAHK
     GELKSIFVVK KLHLGHVAKS FALREQPSLV GKSHHKETMK RKRDERQKGQ QGKKRKKMSG
     TGNRSTQKT