RH42A_DANRE
ID RH42A_DANRE Reviewed; 805 AA.
AC Q6ZM89; F1QUD4;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 3.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Rho GTPase-activating protein 42;
DE AltName: Full=Rho GTPase-activating protein 10-like;
DE AltName: Full=Rho-type GTPase-activating protein 42;
GN Name=arhgap42a {ECO:0000312|ZFIN:ZDB-GENE-030131-8077};
GN ORFNames=si:bz1p14.10, si:rp71-1p14.10;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-164.
RC TISSUE=Testis;
RA Chen F., Jin Y., Zeng K., Gnirke A., Baille M., Cheung L.M., Chong A.,
RA Garrick B., Murray L., Oliva J., Park C., Reyes J., Yang J., Amundsen C.,
RA Orton A., Shao A., Platt D., Swimmer C.;
RT "Exelixis Danio rerio EST project.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May influence blood pressure by functioning as a GTPase-
CC activating protein in vascular smooth muscle.
CC {ECO:0000250|UniProtKB:B2RQE8}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAE47767.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EB935770; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL627325; CAE47767.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BX510940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU695000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EB935770; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q6ZM89; -.
DR SMR; Q6ZM89; -.
DR STRING; 7955.ENSDARP00000126225; -.
DR PaxDb; Q6ZM89; -.
DR ZFIN; ZDB-GENE-030131-8077; arhgap42a.
DR eggNOG; KOG1451; Eukaryota.
DR InParanoid; Q6ZM89; -.
DR PhylomeDB; Q6ZM89; -.
DR Reactome; R-DRE-8980692; RHOA GTPase cycle.
DR Reactome; R-DRE-9013148; CDC42 GTPase cycle.
DR Reactome; R-DRE-9013149; RAC1 GTPase cycle.
DR Reactome; R-DRE-9013404; RAC2 GTPase cycle.
DR Reactome; R-DRE-9013423; RAC3 GTPase cycle.
DR PRO; PR:Q6ZM89; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; GTPase activation; Reference proteome.
FT CHAIN 1..805
FT /note="Rho GTPase-activating protein 42"
FT /id="PRO_0000342408"
FT DOMAIN 7..262
FT /note="BAR"
FT DOMAIN 265..374
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 376..572
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 576..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 225..262
FT /evidence="ECO:0000255"
FT COMPBIAS 625..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 778
FT /note="M -> L (in Ref. 1; CAE47767)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 805 AA; 91152 MW; 138268802D1263F1 CRC64;
MGLPALEFSD SFLDSPDFRE RLKCHEIELD RTNKFIKELI KDGNMLISAL KSLSAAVQKF
SQSLQDFQFE CIGDAETDDE INIAQSFKEF SQLLNTVEEE RRRLIQNADD VLITPLEKFR
KEQIGAAKEG KKKFDKETEK YYTVLEKHLS LSSRKKESLL QEADTQISKE RQVFYDASLE
YVFKIQEVQE RKKFEFVEPL LAFLQGLFTF YHEGYELAHE FEPYKQQLQF NLQNTRNNFE
STRQEVENLM RRIRSAEQDF KAPGQWTMEG FLYVQEKRPL GCTWTRHYCT YEKGTKMFTM
SNSELKTGGK QNGLIMSPPE MFKLKSCIRR RTDSIDKRFC FDIEVVERHG IITLQSLSES
NRRLWMEAMD GKEPIYTLPA LLSKKEETFL NEAGFNFVRK CIESVEARGI NTLGLYRIGG
VNSKVQRLMT SVFAAKAPAD LDLDPDTWDN KTITSGLKNY LRCLAEPLMT YRLHKDFIMA
VKSDDQNYRV CAVHALVYKL PDKNKEMLNL LIKHLHVVST HSQKNLMTVS NLGVIFGPTL
MRSQEETVAA MMNIKFQNIV VEILIENYDK IFHQAPDPNV PLPHPQSHSQ SRGGARRSKA
ICLSSGSRKS RGLYPPALCL ADADSDTFSS SPSSTPMGSM ESLSSHSSEQ NSCSKTGSPS
RNKHKASGSL CWTTPSPSTN GPKSPACTTS PDSSSKEDAN KTDGEWEEAL STSPGDRSSP
ASELLHRTLG ETAEDQRSLS SCSSLTSLHI SEGFRSCHGS IQSLVSRSQR DSLKSLHMPD
LPPKDGMRFR DDSSASNGYQ RPGSV
