ID   RHAA_BACTN              Reviewed;         418 AA.
AC   Q8A1A2;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=L-rhamnose isomerase {ECO:0000255|HAMAP-Rule:MF_00541};
DE            EC=5.3.1.14 {ECO:0000255|HAMAP-Rule:MF_00541};
GN   Name=rhaA {ECO:0000255|HAMAP-Rule:MF_00541}; OrderedLocusNames=BT_3764;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
CC       {ECO:0000255|HAMAP-Rule:MF_00541}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-rhamnopyranose = L-rhamnulose; Xref=Rhea:RHEA:23160,
CC         ChEBI:CHEBI:17897, ChEBI:CHEBI:62346; EC=5.3.1.14;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00541};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00541};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00541};
CC   -!- PATHWAY: Carbohydrate degradation; L-rhamnose degradation; glycerone
CC       phosphate from L-rhamnose: step 1/3. {ECO:0000255|HAMAP-Rule:MF_00541}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00541}.
CC   -!- SIMILARITY: Belongs to the rhamnose isomerase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00541}.
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DR   EMBL; AE015928; AAO78869.1; -; Genomic_DNA.
DR   RefSeq; NP_812675.1; NC_004663.1.
DR   RefSeq; WP_010536410.1; NC_004663.1.
DR   AlphaFoldDB; Q8A1A2; -.
DR   SMR; Q8A1A2; -.
DR   STRING; 226186.BT_3764; -.
DR   PaxDb; Q8A1A2; -.
DR   PRIDE; Q8A1A2; -.
DR   EnsemblBacteria; AAO78869; AAO78869; BT_3764.
DR   GeneID; 45363319; -.
DR   GeneID; 60924934; -.
DR   KEGG; bth:BT_3764; -.
DR   PATRIC; fig|226186.12.peg.3826; -.
DR   eggNOG; COG4806; Bacteria.
DR   HOGENOM; CLU_052790_0_0_10; -.
DR   InParanoid; Q8A1A2; -.
DR   OMA; HKVNLHA; -.
DR   UniPathway; UPA00541; UER00601.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008740; F:L-rhamnose isomerase activity; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019324; P:L-lyxose metabolic process; IBA:GO_Central.
DR   GO; GO:0019301; P:rhamnose catabolic process; IBA:GO_Central.
DR   HAMAP; MF_00541; RhaA; 1.
DR   InterPro; IPR009308; Rhamnose_isomerase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   Pfam; PF06134; RhaA; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Isomerase; Manganese; Metal-binding; Reference proteome;
KW   Rhamnose metabolism.
FT   CHAIN           1..418
FT                   /note="L-rhamnose isomerase"
FT                   /id="PRO_0000090551"
FT   BINDING         262
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00541"
FT   BINDING         294
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00541"
FT   BINDING         296
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00541"
SQ   SEQUENCE   418 AA;  47482 MW;  EFC25B788F3BC353 CRC64;
     MKKEEMIQKA YEIAVERYAA VGVDTEKVLK TMQDFHLSLH CWQADDVTGF EVQAGALSGG
     IQATGNYPGK ARNIDELRAD ILKAASYIPG THRLNLHEIY GDFQGKVVDR DQVEPEHFKS
     WIEWGKEHNM KLDFNSTSFS HPKSGDLSLS NPDEGIRQFW IEHTKRCRAV AEEMGKAQGD
     PCIMNLWVHD GSKDITVNRM KYRALLKDSL DQIFATEYKN MKDCIESKVF GIGLESYTVG
     SNDFYIGYGA SRNKMVTLDT GHFHPTESVA DKVSSLLLYV PELMLHVSRP VRWDSDHVTI
     MDDPTMELFS EIVRCGALER VHYGLDYFDA SINRIGAYVI GSRAAQKCMT RALLEPIAKL
     REYEANGQGF QRLALLEEEK ALPWNAVWDM FCLKNNVPVG EDFIAEIEKY EAEVTSKR