RHAA_YERPE
ID RHAA_YERPE Reviewed; 418 AA.
AC P58507; Q0WJX9;
DT 19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=L-rhamnose isomerase {ECO:0000255|HAMAP-Rule:MF_00541};
DE EC=5.3.1.14 {ECO:0000255|HAMAP-Rule:MF_00541};
GN Name=rhaA {ECO:0000255|HAMAP-Rule:MF_00541};
GN OrderedLocusNames=YPO0329, y0586, YP_0484;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
CC {ECO:0000255|HAMAP-Rule:MF_00541}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-rhamnopyranose = L-rhamnulose; Xref=Rhea:RHEA:23160,
CC ChEBI:CHEBI:17897, ChEBI:CHEBI:62346; EC=5.3.1.14;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00541};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00541};
CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00541};
CC -!- PATHWAY: Carbohydrate degradation; L-rhamnose degradation; glycerone
CC phosphate from L-rhamnose: step 1/3. {ECO:0000255|HAMAP-Rule:MF_00541}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00541}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00541}.
CC -!- SIMILARITY: Belongs to the rhamnose isomerase family.
CC {ECO:0000255|HAMAP-Rule:MF_00541}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM84174.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS60754.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL19013.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84174.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS60754.1; ALT_INIT; Genomic_DNA.
DR PIR; AC0041; AC0041.
DR RefSeq; WP_002209104.1; NZ_WUCM01000014.1.
DR RefSeq; YP_002345409.1; NC_003143.1.
DR AlphaFoldDB; P58507; -.
DR SMR; P58507; -.
DR STRING; 214092.YPO0329; -.
DR PaxDb; P58507; -.
DR DNASU; 1145533; -.
DR EnsemblBacteria; AAM84174; AAM84174; y0586.
DR EnsemblBacteria; AAS60754; AAS60754; YP_0484.
DR GeneID; 57974276; -.
DR KEGG; ype:YPO0329; -.
DR KEGG; ypk:y0586; -.
DR KEGG; ypm:YP_0484; -.
DR PATRIC; fig|214092.21.peg.566; -.
DR eggNOG; COG4806; Bacteria.
DR HOGENOM; CLU_052790_0_0_6; -.
DR OMA; HKVNLHA; -.
DR UniPathway; UPA00541; UER00601.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008740; F:L-rhamnose isomerase activity; IBA:GO_Central.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019324; P:L-lyxose metabolic process; IBA:GO_Central.
DR GO; GO:0019301; P:rhamnose catabolic process; IBA:GO_Central.
DR HAMAP; MF_00541; RhaA; 1.
DR InterPro; IPR009308; Rhamnose_isomerase.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR Pfam; PF06134; RhaA; 1.
DR SUPFAM; SSF51658; SSF51658; 1.
DR TIGRFAMs; TIGR01748; rhaA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Isomerase; Manganese; Metal-binding; Reference proteome;
KW Rhamnose metabolism.
FT CHAIN 1..418
FT /note="L-rhamnose isomerase"
FT /id="PRO_0000090568"
FT BINDING 262
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00541"
FT BINDING 294
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00541"
FT BINDING 296
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00541"
SQ SEQUENCE 418 AA; 47160 MW; C4267475B767A79E CRC64;
MTNSIEQAWD LAKQRFAAVG VDVDAALTRL DTLPVSMHCW QGDDVTGFED PDGVLTGGIQ
ATGNYPGKAR NATELRSDLE LALALIPGPK RLNLHAIYLE SDTPVARNKI EPRHFSHWVA
WAKKHQLGLD FNPSCFSHPL SADGFTLSHA DPEIRQFWIE HCQASRRVSA YFGEQLGTPS
VMNIWIPDGM KDTPIDRLAP RQRLLSALDE VISEKLNPAH HIDAVESKLF GIGAESYTVG
SNEFYMGYAA SRQTALCLDA GHFHPTEVIS DKISSAMLYV PRLLLHVSRP VRWDSDHVVL
LDDETQAIAS EIIRHNLFDR VHIGLDFFDA SINRIAAWVI GTRNMKKALL RALLEPTDRL
RQLELRGDYT ARLALLEEQK SLPWQAIWEG YCQRNDVPVD ARWLDAVREY EQQILSQR
