RHAG_BOVIN
ID RHAG_BOVIN Reviewed; 426 AA.
AC Q9GKN7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Ammonium transporter Rh type A;
DE AltName: Full=Erythrocyte membrane glycoprotein Rh50;
DE AltName: Full=Rhesus blood group family type A glycoprotein;
DE Short=Rh family type A glycoprotein;
DE Short=Rh type A glycoprotein;
DE AltName: CD_antigen=CD241;
GN Name=RHAG; Synonyms=RH50;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Cherif-Zahar B., Raynal V., Cartron J.-P., Matassi G.;
RT "Evolution of RH50 genes in Metazoa.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC a transport or channel function in the erythrocyte membrane. Involved
CC in ammonia transport across the erythrocyte membrane. Seems to act as a
CC monovalent cation transport. {ECO:0000250|UniProtKB:Q02094}.
CC -!- SUBUNIT: Heterotetramer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q02094}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000305}.
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DR EMBL; AF164575; AAG38955.1; -; mRNA.
DR RefSeq; NP_776596.1; NM_174171.2.
DR AlphaFoldDB; Q9GKN7; -.
DR SMR; Q9GKN7; -.
DR STRING; 9913.ENSBTAP00000015012; -.
DR PaxDb; Q9GKN7; -.
DR PRIDE; Q9GKN7; -.
DR GeneID; 281454; -.
DR KEGG; bta:281454; -.
DR CTD; 6005; -.
DR eggNOG; KOG3796; Eukaryota.
DR InParanoid; Q9GKN7; -.
DR OrthoDB; 910733at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0022840; F:leak channel activity; ISS:UniProtKB.
DR GO; GO:0072488; P:ammonium transmembrane transport; ISS:UniProtKB.
DR GO; GO:0006873; P:cellular ion homeostasis; ISS:UniProtKB.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; ISS:UniProtKB.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 2: Evidence at transcript level;
KW Ammonia transport; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..426
FT /note="Ammonium transporter Rh type A"
FT /id="PRO_0000380192"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..292
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..371
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 393..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 426 AA; 46719 MW; C4899A8406E09E51 CRC64;
MRFKFPLMAI GLEVVMIVLF ALFVQYETSV NTSRNPNETE SAAMDVEKTM ESYPFFQDVH
IMVFAGFGFL MTFLWKYGFS GVGINLLIAA LGLQWGTIIQ GIFRSHGQKF LIEMKNMIHA
DFSTVTVLIS FGAVLGKTSP VQMLIMTILE ITVYAANEYL VFKILWASDT GESMTIHAFG
AYFGLAVAGI LYRSGLKEKH SNEESVYHSD LFAMIGSLFL WIFWPSFNSA TADEAKKQYR
AIVNTYFSLA ASVVTAYACS SLLESRGKLN MVHIQNATLA GGVAVGTCAD MEIPPYYAMI
IGSIAGAVSV FGFKFLTPLF TTKLRIHDTC GVHNLHGLPG VIGGLAGIIT VALEESDSTK
TVSQAAALGS SIATALVGGL ITGAILKIPF WAQPPDEDCY DDSVYWEVPE RKEYDNHFHE
LLSTLH
