ID   RHAR_ENT38              Reviewed;         282 AA.
AC   A4WG90;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=HTH-type transcriptional activator RhaR {ECO:0000255|HAMAP-Rule:MF_01533};
DE   AltName: Full=L-rhamnose operon transcriptional activator RhaR {ECO:0000255|HAMAP-Rule:MF_01533};
GN   Name=rhaR {ECO:0000255|HAMAP-Rule:MF_01533}; OrderedLocusNames=Ent638_4065;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- FUNCTION: Activates expression of the rhaSR operon in response to L-
CC       rhamnose. {ECO:0000255|HAMAP-Rule:MF_01533}.
CC   -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000255|HAMAP-Rule:MF_01533}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01533}.
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DR   EMBL; CP000653; ABP62720.1; -; Genomic_DNA.
DR   RefSeq; WP_015961024.1; NC_009436.1.
DR   AlphaFoldDB; A4WG90; -.
DR   SMR; A4WG90; -.
DR   STRING; 399742.Ent638_4065; -.
DR   EnsemblBacteria; ABP62720; ABP62720; Ent638_4065.
DR   KEGG; ent:Ent638_4065; -.
DR   eggNOG; COG1917; Bacteria.
DR   eggNOG; COG4977; Bacteria.
DR   HOGENOM; CLU_000445_88_5_6; -.
DR   OMA; NREVGMT; -.
DR   OrthoDB; 1268974at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0019299; P:rhamnose metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_01533; HTH_type_RhaR; 1.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR023699; Tscrpt_act_RhaR.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repeat; Rhamnose metabolism;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..282
FT                   /note="HTH-type transcriptional activator RhaR"
FT                   /id="PRO_1000068696"
FT   DOMAIN          179..277
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT   DNA_BIND        196..217
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT   DNA_BIND        244..267
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT   SITE            246
FT                   /note="Interaction with sigma-70"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
SQ   SEQUENCE   282 AA;  32428 MW;  99D2CF9138688358 CRC64;
     MGVPLILRKT DFFANAGQAV AVADRYPQNV FAEHTHEFCE LVLVWRGNGL HVLNDRPYRI
     TRGDLFYIRA EDKHSYASVN DLVLQNVIYC PDRLKLNVDW ASNIPGFNDA RGAPHWRLSS
     NGMGQVRPVI TQLEQESLKA DQSANEMAEL LFAQLVMTLK RFRYATDNPS ANEQEALLDK
     LITALAGSLN RSFVLEKFCE QEQCSERALR QQFRTQTGMT VNHYLRQLRI CHAQYLLQHT
     ELMVSEVAMR CGFEDSNYFS VVFNREVGMT PVQWRHRSRK AA