ID   RHAR_KLEP7              Reviewed;         281 AA.
AC   A6TGB0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=HTH-type transcriptional activator RhaR {ECO:0000255|HAMAP-Rule:MF_01533};
DE   AltName: Full=L-rhamnose operon transcriptional activator RhaR {ECO:0000255|HAMAP-Rule:MF_01533};
GN   Name=rhaR {ECO:0000255|HAMAP-Rule:MF_01533};
GN   OrderedLocusNames=KPN78578_41700; ORFNames=KPN_04215;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activates expression of the rhaSR operon in response to L-
CC       rhamnose. {ECO:0000255|HAMAP-Rule:MF_01533}.
CC   -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000255|HAMAP-Rule:MF_01533}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01533}.
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DR   EMBL; CP000647; ABR79594.1; -; Genomic_DNA.
DR   RefSeq; WP_002882891.1; NC_009648.1.
DR   AlphaFoldDB; A6TGB0; -.
DR   SMR; A6TGB0; -.
DR   STRING; 272620.KPN_04215; -.
DR   PRIDE; A6TGB0; -.
DR   EnsemblBacteria; ABR79594; ABR79594; KPN_04215.
DR   GeneID; 61330437; -.
DR   KEGG; kpn:KPN_04215; -.
DR   HOGENOM; CLU_000445_88_5_6; -.
DR   OMA; NREVGMT; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0019299; P:rhamnose metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_01533; HTH_type_RhaR; 1.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR023699; Tscrpt_act_RhaR.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Repeat;
KW   Rhamnose metabolism; Transcription; Transcription regulation.
FT   CHAIN           1..281
FT                   /note="HTH-type transcriptional activator RhaR"
FT                   /id="PRO_0000319847"
FT   DOMAIN          178..276
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT   DNA_BIND        195..216
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT   DNA_BIND        243..266
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT   SITE            245
FT                   /note="Interaction with sigma-70"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
SQ   SEQUENCE   281 AA;  32206 MW;  542A0882ED497F13 CRC64;
     MAGLILRKEE FFPSATQAVA VADRYPQNVF AEHTHEFCEL VLVWRGNGLH VLNDRPWRIT
     RGDLFYIRAE DKHSYASVND LVLQNIIYCP ERLQLNFDWA GAIPGLFGTP WKPHWRMGST
     GMAQARQVIS QLEHECARRD AQGNAMAELL FAQLALTLQR HRYATDDPAA TQREALLDKL
     LAALAASLSR PFVLERFCEQ EGGSERALRQ QFRQQTGMTI NHYLRQLRIC HAQYLLQHTE
     RLIGDIAMQC GFEDSNYFSV VFSREIGMSP GQWRQRSRAA A